Summary Background It is not clear whether the incidence or early mortality related to peptic ulcer perforation has changed. Aim To evaluate and while considering intake of low‐dose aspirin nonsteroidal anti‐inflammatory drugs (NSAIDs). Methods We recorded numbers details all patients presenting in our region Scotland with between 1997 2006 including demography, drug usage 30‐day mortality. Results In subjects aged >65 years, annual was 32.7 per 10 5 age‐specific population, whom 10.7...

Summary Background Rofecoxib was withdrawn in 2004. Aim To assess the incidence of upper gastrointestinal bleeding context changing use cyclo‐oxygenase‐2 non‐steroidal anti‐inflammatory drugs and low‐dose aspirin. Methods We examined characteristics patients developing a defined population south‐west Scotland. The primary comparisons were made between two calendar years, preceding following withdrawal rofecoxib. Results overall rose from 98.7 2002 to 143 per 10 5 annum 2005 ( χ 2 = 21.1; P...

Abstract Introduction Partial nephrectomy is currently the preferred treatment option for T1a renal cell carcinomas (RCC), with nephron‐sparing techniques, including microwave ablation, becoming more common in select patients. Primary aims are to document outcomes of ablation RCCs an Australian tertiary centre add evidence its safety and efficacy. Methods The prospectively maintained Sir Charles Gairdner Hospital Interventional Radiology database was retrospectively searched all Renal...

While efforts have focused on the prevention of overt upper gastrointestinal bleeding (UGIB), little is known about occult GIB, which might also originate from sites not protected by acid inhibition.To measure incidence and outcomes both GIB over a 6-year period (2007-2012), to assess use NSAIDs, anti-thrombotic therapy (ATT), proton pump inhibitors (PPIs), iron therapy.A sample 300 patients (100 each three index years) with was randomly selected their were compared those UGIB (N = 869).The...

<h3>Introduction</h3> Blood transfusion is integral to the management of non-variceal upper gastrointestinal bleeding (NV-UGIB), but its safety being questioned in less severe cases. We, therefore aimed measure 30-day and 2-year mortality after blood for NV-UGIB. <h3>Methods</h3> This was an observational analysis using routinely collected data at a single hospital southwest Scotland affiliated Glasgow University. Cox proportional hazards models were used estimate effect on while adjusting...

Despite medical school cohorts being composed of approximately 50% men and women, trainee positions in Clinical Radiology remain predominantly occupied by men. This study aims to identify reasons behind the gender gap, explore why more women are not pursuing a career assess if there differences these reasons.

<h3>Introduction</h3> The use of antithrombotic drugs (ATDs) remains a considerable challenge in the aetiology and management non-variceal upper gastrointestinal bleeding (NVUGIB). In tract, ATD may result by mucosal damage (ulcer effect) or through its basic effect. clinical significance these effects is unclear. this controlled analysis, we AIMED to clarify effect as compared with ulcer patients NVUGIB using ATDs. <h3>Methods</h3> We previously found that users tended be older have higher...

<h3>Introduction</h3> Nicorandil is a vasodilatory drug that has the dual properties of nitrate and K+ATP channel agonist. It often added to ATDs in management angina. In light some case reports, its manufacturer medicines regulatory agencies have issued cautions it can cause mucosal ulcers, perforation bleeding, these might be worse users aspirin. We therefore aimed investigate possibility NVUGIB more severe patients using plus than alone. <h3>Methods</h3> Patients presenting with (n = 59)...

<h3>Introduction</h3> Efforts have been focused on the prevention of overt upper gastrointestinal bleeding (UGIB), using acid inhibitors, particularly in users NSAIDs and anti-thrombotic therapy (ATT). Little is known about impact such efforts occult GIB which might also originate from sites not protected by inhibition. We aimedto measure incidence both a well-defined geographical region over 5-year period, 2007–2012; assess use NSAIDs, ATT, PPIs, iron therapy; compare outcomes patients with...

<h3>Introduction</h3> Antithrombotic drugs (ATDs) commonly cause non-variceal upper gastrointestinal bleeding (NVUGIB). Established risk scoring systems have not been validated in users of these drugs. We aimed to compare Blatchford, Rockall, and Charlson scores predicting the outcomes NVUGIB ATD controls. <h3>Methods</h3> A total 2071 patients with NVUGIB, 2005–2011, were grouped into (n = 851) controls 1220). ATDs included low-dose aspirin, clopidogrel, dipyridamole, warfarin,...

<h3>Introduction</h3> The prevention of upper gastrointestinal bleeding (UGIB) can be facilitated by understanding the changes in environmental and socio-pathological factors; these might not become obvious short-term studies. We, therefore, aimed to study comorbidity risk scores their influence on outcomes UGIB over a 14-year period. <h3>Methods</h3> We analysed clinical characteristics all patients presenting with single institution, 1996–2010. Charlson’s complete Rockall were analysed,...

<h3>Introduction</h3> Proton pump inhibitors (PPIs), when given following endoscopy for acute upper gastrointestinal bleeding (UGIB), can reduce the need blood transfusion and surgery; little is known about their benefit used in period before endoscopy. We therefore aimed to investigate outcomes of UGIB patients intravenous PPIs <h3>Methods</h3> A total 404 with were included; 202 received omeprazole a median 1 day (IQR 0.25–2) did not, this treatment being at physician’s discretion....

<h3>Introduction</h3> The use of antiplatelet agents for vascular protection continues to increase and this has been associated with serious complications including upper gastrointestinal bleeding (UGIB). clinical outcomes following such complication remains poorly understood. We, therefore, aimed measure 30-day mortality other in patients presenting UGIB while using as compared those non-steroidal anti-inflammatory drugs (NSAIDs) neither these agents. <h3>Methods</h3> Patients were included...

<h3>Introduction</h3> It is not clear what impact the decline of COX-2 selective inhibitors has had on use non-selective non-steroidal anti-inflammatory drugs (ns-NSAIDs) or incidence non-variceal upper gastrointestinal bleeding (NV-UGIB). Also, proton pump (PPIs), recommended for NSAID-ulcer prophylaxis, have been linked to <i>Clostridium difficile</i> infection. <h3>Methods</h3> We aimed measure [cases per 100 000 population annum] NV-UGIB and <i>C infection as well ns-NSAIDs PPIs in a...

<h3>Introduction</h3> Upper gastrointestinal bleeding (UGIB) developing while in hospital is traditionally thought to be due stress ulceration affecting critically ill patients. The role of potentially damaging drugs not clear. <h3>Aims</h3> Given the increasing use low-dose aspirin and other antithrombotic drugs—clopidogrel, dipyridamole, warfarin—for vascular protection, we aimed clarify their impact on UGIB hospitalised <h3>Methods</h3> Between 2008 2009, prospectively assessed clinical...

Introduction Despite being the third most common cancer, after those of lung and breast, treatment bowel cancer may have more than 90% success rate if it is detected early. This has prompted many health authorities to invest in screening programmes. AIMS Given wide use aspirin NSAIDs their potential effects on gut mucosa, we aimed compare bowel-screening colonoscopic findings users vs. non-users these agents. Method In our area – with a population 370590 subjects aged 50–74 years were...