A5009849052- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Lung Cancer Treatments and Mutations
- Mosquito-borne diseases and control
- PI3K/AKT/mTOR signaling in cancer
- Blood transfusion and management
- Microbial Metabolism and Applications
- Autophagy in Disease and Therapy
- Pharmacogenetics and Drug Metabolism
- Microbial Applications in Construction Materials
- Phytochemistry and Bioactive Compounds
- Infrared Thermography in Medicine
- Hepatitis B Virus Studies
- Viral Infections and Outbreaks Research
- AI in cancer detection
- Peptidase Inhibition and Analysis
- Erythrocyte Function and Pathophysiology
- Computational Drug Discovery Methods
- Alzheimer's disease research and treatments
- Blood donation and transfusion practices
- Cancer Mechanisms and Therapy
- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- Chronic Lymphocytic Leukemia Research
- Metabolomics and Mass Spectrometry Studies
University of Liverpool
2021-2025
King Abdulaziz University
2023-2024
There are millions of cancer cases worldwide every year, and breast is one the most prevalent diseases with highest mortality rate. The manual effort pathologists can be significantly reduced by computerized diagnostic systems, which improve accuracy reliability diagnosis. In this paper, we present four novel systems for diagnosis in different scenarios: binary versus multi-class classification magnification-specific (MS) magnification-independent (MI) classification. each proposed developed...
Abstract Despite the vital activity of many compounds, they lack that effectiveness due to their low solubility in water. Unfortunately, for this reason, rutin often leads tissue permeability and insufficient bioavailability, which has greatly limited its pharmacological utility. Therefore, present investigation is designed overcome problem by formulating rotin nanocrystals (RNCs) with studying some applications vitro silico. RNCs were created via ultrasonication approach showed a spherical...
<title>Abstract</title> Biomarkers that predict disease progression and treatment-free remission (TFR) would be of significant clinical value in chronic myeloid leukaemia (CML). We have previously shown CIP2A levels at diagnosis can identify patients increased risk progression. One mechanism by which acts is through upregulation the anti-apoptotic gene BCL-XL. In this study, we evaluated BCL-XL mRNA expression as a diagnostic biomarker using samples from SPIRIT 2 DESTINY trials. 2, compared...
The emergence of multidrug-resistant bacteria presents a significant global health risk, necessitating the exploration alternative treatment options. This in vitro study aimed to evaluate efficacy Saudi honey Clover and Talh against Gram-negative positive bacteria, including Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus epidermidis Methicillin-resistant aureus. All tested were collected two types diluted stored. is followed by microbiological identification,...
Background: It would be clinically useful to prospectively identify the risk of disease progression in chronic myeloid leukaemia (CML). Overexpression cancerous inhibitor protein phosphatase 2A (PP2A) (CIP2A) is an adverse prognostic indicator many cancers. Methods: We examined CIP2A levels diagnostic samples from SPIRIT2 trial 172 unselected patients, whom 90 received imatinib and 82 dasatinib as first-line treatment. Results: High correlated with inferior progression-free survival (p =...
Ebola virus (EBOV) poses a severe threat as highly infectious pathogen, causing devastating hemorrhagic fever in both humans and animals. The EBOV VP35 protein plays crucial role viral replication exhibits the ability to suppress host interferon cascade, leading immune system depletion. As potential drug target, inhibition holds promise for combating EBOV. To discover new candidates, we employed computer-aided design approach, focusing on compounds capable of inhibiting replication. In this...
Dengue, caused by the dengue virus (DENV), a member of flavivirus family, continues to pose significant threat populations worldwide, despite advances in technology. Nearly half global population is at risk contracting disease, ranging from mild fever (DF) severe hemorrhagic (DHF) and Dengue Shock Syndrome (DSS). The precise mechanisms underlying progression DF DHF DSS remain unclear, presence various DENV serotypes exacerbates this situation. Urbanization climate change are expected affect...