A5055177375- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Inflammatory Bowel Disease
- Dysphagia Assessment and Management
- Biosimilars and Bioanalytical Methods
- Liver Disease Diagnosis and Treatment
- Celiac Disease Research and Management
- Immunodeficiency and Autoimmune Disorders
- Appendicitis Diagnosis and Management
- Liver Disease and Transplantation
- Tracheal and airway disorders
- Pancreatic and Hepatic Oncology Research
- Liver Diseases and Immunity
- Diet and metabolism studies
- Gut microbiota and health
- Pharmaceutical studies and practices
- Eosinophilic Esophagitis
- Diagnosis and treatment of tuberculosis
- Radiomics and Machine Learning in Medical Imaging
- Mycobacterium research and diagnosis
- Hydrogen's biological and therapeutic effects
- Microscopic Colitis
- Clostridium difficile and Clostridium perfringens research
- Autoimmune and Inflammatory Disorders Research
- Pancreatitis Pathology and Treatment
Istituti di Ricovero e Cura a Carattere Scientifico
2023-2025
Università Cattolica del Sacro Cuore
2023-2025
Agostino Gemelli University Polyclinic
2023-2025
Centro Clinico Nemo
2023
Inflammatory bowel diseases (IBD), comprising Crohn's disease and ulcerative colitis, are systemic multifaceted disorders which affect other organs in addition to the gastrointestinal tract up 50% of cases. Extraintestinal manifestations may present before or after IBD diagnosis negatively impact intestinal course patients' quality life, often requiring additional diagnostic evaluations specific treatments. Non-alcoholic fatty liver (NAFLD) is most common worldwide. Current evidence shows an...
Gut microbiota (GM) modulation can be investigated as possible solution to enhance recovery after COVID-19. An open-label, single-center, single-arm, pilot, interventional study was performed by enrolling twenty patients recently recovered from COVID-19 investigate the role of a mixed probiotic, containing Lactobacilli, Bifidobacteria and Streptococcus thermophilus, on gastrointestinal symptoms, local systemic inflammation, intestinal barrier integrity GM profile. Gastrointestinal Symptom...
Abstract Background Immune-mediated inflammatory diseases (IMID) can coexist within the same patient and their pathogenesis could overlap. Inflammatory bowel disease (IBD) [Crohn’s (CD) ulcerative colitis (UC)], spondylarthritis (SpA), often associate, but biomarkers are not fully characterized. This project aims to investigate a possible molecular signature of predictor markers response Methods We performed an observational prospective study, enrolling consecutive IMID patients (pts)...
Abstract Background During their lifetime, patients with Crohn’s disease (CD) frequently develop strictures as a complication, where various degrees of inflammation and fibrosis coexist. Distinguishing between inflammatory fibrotic is crucial for deciding on surgery or treatment changes, yet it currently challenging in clinical practice. Cross-sectional imaging techniques (e.g. magnetic resonance MRI) provide reasonably accurate estimate bowel wall fibrosis. However, only histopathological...
Background and Aims: Subcutaneous vedolizumab formulation has been shown to be as effective safe the intravenous one in randomized control trials. Real-life data are limited especially for patients receiving long-term therapy. This study aimed evaluate safety effectiveness of switching from subcutaneous a large cohort with stable clinical remission.
 Methods: In this prospective study, we enrolled consecutive attending our center between September 2021 April 2022. The baseline...
CMV infection is still a matter of concern in IBD patients, especially regarding the disease’s relapse management. Why particularly those affected by ulcerative colitis, are more susceptible to reactivation not totally explained, although weakened immune system could be reason. Various techniques, ranging from serology histology, can employed detect intestinal infection; however, there currently disagreement literature most effective diagnostic test. Furthermore, involvement steroid...
Abstract Background Comparative data regarding ustekinumab (UST) and vedolizumab (VDZ) effectiveness safety in elderly inflammatory bowel disease (IBD) patients are limited. The aim of the present nationwide multicenter cohort study was to compare persistence these drugs versus non-elderly Italian IBD patients. Methods Data from 20 centers were retrospectively collected. Based upon age treatment, aged ≥65 years allocated group 1 (G1) 3 (G3) (cases) if treated with UST or VDZ, respectively, 2...
Abstract Background Immune-mediated inflammatory diseases (IMID) are an emerging problem in Western world. Despite being traditionally considered nosologically distinct entities, two or more IMID can coexist within the same patient and their pathogenesis overlap to a certain extent. Two IMID, bowel disease (IBD) spondylarthritis (SpA), often associate, but remains unknown biomarkers not fully characterized. This project aims investigate pathogenic predictor markers of response Methods A...