A5037206736- Oral microbiology and periodontitis research
- HIV/AIDS drug development and treatment
- Herpesvirus Infections and Treatments
- Oral and gingival health research
- HIV Research and Treatment
- HIV/AIDS oral health manifestations
Colorado State University
2023-2025
Feline immunodeficiency virus (FIV) is the domestic cat analogue of HIV infection in humans. Both viruses induce oral disease untreated individuals, with clinical signs that include gingivitis and periodontal lesions. Oral manifestations patients are abated by highly effective combination antiretroviral therapy (cART), though certain persist despite therapy. Microorganisms associated cavity opportunistic infections cause similar pathologies cats. To further develop this model, we evaluated...
Feline Immunodeficiency Virus (FIV) causes progressive immune dysfunction in cats similar to human immunodeficiency virus (HIV) humans. Although combination antiretroviral therapy (cART) is effective against HIV, there no definitive improve clinical outcomes with FIV. This study therefore evaluated pharmacokinetics and of cART (2.5 mg/kg Dolutegravir; 20 Tenofovir; 40 Emtricitabine) FIV-infected domestic cats. Specific pathogen free were experimentally infected FIV administered either or...