A5020249105- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Neuroendocrine Tumor Research Advances
- Thyroid and Parathyroid Surgery
- Growth Hormone and Insulin-like Growth Factors
- Diabetes and associated disorders
- Parathyroid Disorders and Treatments
- Neonatal Health and Biochemistry
- Medical Imaging and Pathology Studies
- Radiopharmaceutical Chemistry and Applications
- Metabolism, Diabetes, and Cancer
- Pregnancy and preeclampsia studies
- Folate and B Vitamins Research
- Parkinson's Disease Mechanisms and Treatments
- Head and Neck Anomalies
- Religious, Philosophical, and Educational Studies
- Ultrasound and Hyperthermia Applications
- Cardiac Imaging and Diagnostics
- Neurological disorders and treatments
- Advanced MRI Techniques and Applications
- Radiation Dose and Imaging
- Bariatric Surgery and Outcomes
- Lung Cancer Research Studies
- Nutritional Studies and Diet
Ljubljana University Medical Centre
2015-2024
University of Ljubljana
2016-2024
University Medical Center
2021
Association for Symbolic Logic
2015
Hashimotos thyroiditis (HT) is the most prevalent autoimmune thyroid disorder. Intrathyroidal lymphocytic infiltration followed by a gradual destruction of gland which may lead to subclinical or overt hypothyroidism. Biochemical markers disease are peroxidase and/or thyroglobulin autoantibodies in serum present with higher prevalence females than males and increase age. Although exact mechanisms aetiology pathogenesis disorder not completely understood, strong genetic susceptibility has been...
Background: Knowledge about the population's iodine status is important, because it allows adjustment of supply and prevention deficiency. The validity comparability iodine-related population studies can be improved by standardization, which was one goals EUthyroid project. aim this study to establish first standardized map in Europe using urinary concentration (UIC) data. Materials Methods: We established a gold-standard laboratory Helsinki measuring UIC inductively coupled plasma mass...
To evaluate the effect of once-weekly subcutaneous semaglutide 1.0 mg on late digestive period gastric emptying (GE) after ingestion a standardized solid test meal by using technetium scintigraphy, reference method for this purpose.We conducted single-blind, placebo-controlled trial in 20 obese women with polycystic ovary syndrome (PCOS; mean [range] age 35 [32.3-40.8] years, body mass index 37 [30.7-39.8] kg/m2 ) randomized to once weekly or placebo 12 weeks. GE was assessed [99mT c]...
To assess the short-term efficacy and safety of ultrasonographically (US)-guided high-intensity focused ultrasound (HIFU) ablation for treatment benign solid thyroid nodules.This prospective study was approved by institutional ethics committee, written informed consent acquired. HIFU performed in one session with US guidance conscious sedation 20 euthyroid patients (mean age, 44.5 years) a solitary or dominant nodule. Thyroid nodule volume, structure, Doppler pattern were assessed at...
Primary hyperparathyroidism (PHPT) is a common endocrine disorder, definitive treatment usually requiring surgical removal of the offending parathyroid glands. To perform focused approaches, it necessary to localize all hyperfunctioning The aim study was compare efficiency established conventional scintigraphic imaging modalities with emerging <sup>18</sup>F-fluorocholine PET/CT in preoperative localization glands larger series PHPT patients. <b>Methods:</b> In total, 103 patients were...
Parathyroid subtraction scintigraphy (PSS) is the most commonly used imaging method for localisation of hyperfunctioning parathyroid glands (HPGs) in primary hyperparathyroidism (PHP), a common endocrine disorder. Hybrid (SPECT/CT) with 99mTc-sestaMIBI (MIBI) at an early and delayed phase (dual-phase imaging) may be accurate conventional approach, but includes additional radiation exposure due to added CT imaging. Recently, 18F-choline (FCH) PET/CT was introduced HPG imaging, which can also...
Several studies conducted around the world showed substantial vitamin D insufficiency and deficiency among different population groups. Sources of in human body include ultraviolet B (UVB)-light-induced biosynthesis dietary intake, but people’s diets are often poor D. Furthermore, many regions, sun exposure intensity UVB irradiation during wintertime not sufficient for biosynthesis. In Slovenia, epidemiological data about status were investigated through a national Nutrihealth study—an...
To assess iodine supply and follow thyroid epidemiology for ten years after an increase from 10 to 25 mg of potassium iodide per kilogram salt in 1999.In 2002 2003, we determined the size by palpation ultrasound measured urinary concentration (UIC) 676 schoolchildren 34 schools throughout Slovenia. From 1999 2009, followed incidence diffuse nodular goiter, autonomy, Graves' disease, Hashimoto's thyroiditis among adults stable catchment area University Medical Centre Ljubljana with 1000000...
From a series of radiolabelled cholecystokinin (CCK) and gastrin analogues, (111)In-CP04 ((111)In-DOTA-(DGlu)6-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2) was selected for further translation as diagnostic radiopharmaceutical towards first-in-man study in patients with medullary thyroid carcinoma (MTC). A freeze-dried kit formulation multicentre application has been developed. We herein report on biosafety, vivo stability, biodistribution dosimetry aspects animal models, essential the regulatory...
Folate deficiency is associated with various health issues, including anemia, cardiovascular disease, and birth defects. Low folate intake suboptimal status were found in several countries; however, this topic has not yet been investigated Slovenia. Dietary serum through the nationally representative food consumption study SI.Menu/Nutrihealth. was estimated using a sample of N = 1248 subjects aged 10-74 years, stratified three age groups (adolescents, adults, elderly population), two 24...
Vitamin B12 deficiency poses a health concern, especially in vulnerable populations. Dietary vitamin intake was obtained by two 24 h dietary recalls and food propensity questionnaires representative Slovenian cross-sectional consumption survey, SI.Menu (n = 1248 subjects; 10–74 years). For subgroup of 280 participants, data on serum were available through the Nutrihealth study. The estimated usual population-weighted mean daily intakes 6.2 µg (adults), 5.4 (adolescents), 5.0 (elderly). Lower...
To assess the long term efficacy and tolerability of one or two ultrasound (US)-guided high-intensity focused (HIFU) treatment in patients with breast fibroadenoma (FA).Twenty 26 FA were selected for US-guided HIFU. The therapy was performed sessions. volume assessed before followed up to 24 months after last After each treatment, adverse events evaluated.In 19/26 (73.1%) HIFU (group 1), whereas 7/26 (26.9%) received second 2) 6-9 (median, 7 months) first session. In group 1 2, decreased...
Increasing evidence supports the genetic susceptibility for thyroid antibody (TAb) production in patients with autoimmune disease, and recently, it has been shown that cytotoxic T lymphocyte antigen 4 (CTLA-4) gene is most likely a major TAb gene. To assess relationship between exon 1 CTLA-4 polymorphism production, we genotyped 67 newly diagnosed Graves' disease. Free hormones were measured, including thyroglobulin antibodies (TgAb), peroxidase (TPOAb), thyroid-stimulating (TSAb). AA...
Summary Strong genetic susceptibility to thyroid autoantibody (TAb) diathesis has been shown and one of the major genes involved is probably CTLA‐4 gene. Our recent study patients with Graves’ disease demonstrated that exon 1 gene polymorphism influences higher TAb production. Here, we evaluated influence promoter polymorphisms on production in 109 newly diagnosed Hashimoto's thyroiditis (HT). Serum TSH, peroxidase antibodies (TPOAb) thyroglobulin (TgAb) were measured. 49 A/G −318 C/T...
Abstract Introduction Medullary thyroid cancer (MTC) is a rare malignant tumour of the parafollicular C-cells with an unpredictable clinical course and currently suboptimal diagnostic therapeutic options, in particular advanced disease. Overexpression cholecystokinin-2 receptors (CCK2R) represents promising avenue to imaging targeted therapy, ideally through theranostic approach. Materials methods A translational study (GRAN-T-MTC) conducted Phase I multicentre trial indium-111 labelled CP04...
Objective The first dose of radioiodine (131I) does not always cure hyperthyroidism in patients with Graves' disease (GD). Our aim was to evaluate the factors influencing success 131I therapy. Patients and methods We reviewed medical records 724 who were diagnosed GD between 2005 2009 subsequently treated a fixed-dose manner considering thyroid volume (TV). TSH, fT4, fT3 measured. TV measured by means ultrasonography. Successful therapy followed euthyroidism or hypothyroidism. Results Out...
Hashimoto's thyroiditis (HT) is the most prevalent thyroid autoimmune disorder, characterized by presence of specific autoantibodies (TAb). The development autoimmunity, including TAb production and clinical presentation HT, determined a complex interplay genetic susceptibility several endogenous environmental factors, which are discussed in this article. During progression disease, precedes manifestations, although correlation between concentrations function weak. We do not treat euthyroid...