A5043407612- Cutaneous Melanoma Detection and Management
- Skin Protection and Aging
- Melanoma and MAPK Pathways
- CAR-T cell therapy research
- Breast Cancer Treatment Studies
- melanin and skin pigmentation
- Nonmelanoma Skin Cancer Studies
- Thyroid Cancer Diagnosis and Treatment
- Breast Implant and Reconstruction
- Cancer Genomics and Diagnostics
- Parathyroid Disorders and Treatments
- Cutaneous lymphoproliferative disorders research
- BRCA gene mutations in cancer
- Microbial Inactivation Methods
- Health Systems, Economic Evaluations, Quality of Life
- Microfluidic and Bio-sensing Technologies
- Cancer Diagnosis and Treatment
- Dermatology and Skin Diseases
- S100 Proteins and Annexins
- Pituitary Gland Disorders and Treatments
- Global Cancer Incidence and Screening
- Lymphatic System and Diseases
- Advances in Oncology and Radiotherapy
- Cancer and Skin Lesions
- Allergic Rhinitis and Sensitization
Institute of Oncology Ljubljana
2016-2025
University of Ljubljana
2019-2025
Pomeranian Medical University
2017
UNSW Sydney
2010
Prince of Wales Hospital
2010
Karolinska Institutet
2010
The life expectancy in the Western world is increasing for a long time, which courtesy of higher standard, more thorough hygiene, and, course, progress modern medicine. Nevertheless, one illnesses that still proves to be great challenge regardless recent advancements medicine cancer. Skin cancer is, according World Health Organization, most common malignancy white population. beginning paper offers brief overview latest available information concerning epidemiology, aetiology, diagnostics,...
The incidence of melanoma continues to increase in many countries, and primary prevention includes avoidance sunburn as well adequate sun protection behavior. aim this study was examine the prevalence self-reported behaviors users Internet, identify demographic, clinical, attitudinal/motivational correlates behaviors.Self-report data were gathered on behalf GenoMEL consortium using an online survey available 10 different languages, 8,178 individuals successfully completed at least 80% items,...
Electrochemotherapy (ECT) is an effective locoregional therapy for cutaneous melanoma metastases and has been safely combined with immune checkpoint inhibitors in preliminary experiences. Since ECT known to induce immunogenic cell death, its combination might be beneficial. In this study, we aimed investigate the effectiveness of on pembrolizumab. We undertook a retrospective matched cohort analysis stage IIIC–IV patients, included International Network sharing practices (InspECT) Slovenian...
Background: Patients with cancer often have to make complex decisions about treatment, the options varying in risk profiles and effects on survival quality of life. Moreover, inefficient care paths it hard for patients participate shared decision-making. Data-driven decision-support tools potential empower patients, support personalized care, improve health outcomes promote equity. However, currently seldom consider life or individual preferences, their use clinical practice remains limited,...
Cutaneous melanoma continues to increase in incidence many countries, and intentional tanning is a risk factor for melanoma. The aim of this study was understand how factors, perceived threat preferences suntan relate tanning. Self-report data were collected on behalf GenoMEL (www.genomel.org) from the general population using an online survey. A total 8178 individuals completed survey, with 72.8% respondents being Europe, 12.1% Australia, 7.1% US, 2.5% Israel 5.5% other countries. Seven...
Increased level of serum S100B can serve as a marker metastatic spread in patients with cutaneous melanoma (CM). In elevated S100 B and/or clinical signs disease progression PET-CT scan is valuable tool for discovering metastases and planning treatment.The aims this study were to determine whether regular measurements are useful CM evaluate the diagnostic value during follow-up.From September 2007 February 2010, 115 included follow up at Institute Oncology Ljubljana appointed PET-CT. There...
To examine the frequency and correlates of skin examination behaviors in an international sample individuals at varying risk developing melanoma.A cross-sectional, web-based survey.Data were collected from general population over a 20-month period on behalf Melanoma Genetics Consortium (GenoMEL).A total 8178 adults Northern (32%), Central (33%), Southern (14%) Europe, Australia (13%), United States (8%).Self-reported self-examination (SSE) clinical (CSE).After adjustment for age sex, was...
Abstract Background The Evaluation of Groin Lymphadenectomy Extent for Melanoma (EAGLE FM) study sought to address the question whether perform inguinal (IL) or ilio-inguinal lymphadenectomy (I-IL) patients with nodal metastatic melanoma who have no clinical imaging evidence pelvic disease. Primary outcome measure was disease-free survival at 5 years, and secondary endpoints included lymphoedema. Methods EAGLE FM designed recruit 634 but closed 88 randomised because slow recruitment changes...
Abstract The successful implementation of artificial intelligence (AI) in healthcare is dependent upon the acceptance this technology by key stakeholders, particularly patients, who are primary beneficiaries AI-driven outcomes. This international, multicenter, cross-sectional study assessed attitudes hospital patients towards AI across 43 countries. A total 13806 at 74 hospitals were surveyed between February and November 2023, with 64.8% from Global North 35.2% South. findings indicate a...
The population of elderly people is increasing and so the breast cancer patients aged ≥80 years. aim our retrospective study was to identify independent prognostic factors for duration cancer-specific survival surgically treated secondary determine appropriate surgical treatment in We reviewed medical records 154 years with early-stage (mean age 83 years) who underwent surgery at tertiary center period from 2000 2008. Tumor stage pT1/pT2 pT3/pT4 75% 25%, respectively. Surgical comprised:...
Carotid paragangliomas are usually slowly enlarging and painless lateral neck masses. These mostly benign lesions recognized due to their typical location, vessel displacement specific blood supply, features that seen on different imaging modalities. Surgery for carotid paraganglioma can be associated with immediate cerebrovascular complications or delayed neurological impairment. We reporting the case of a 36-year-old man who presented mass right side his 11 months after being treated...
To determine the frequency and type of RET mutation in Slovenian medullary thyroid cancer (MTC) patients estimate crude annual incidence MTC Slovenia.This referral-center retrospective analysis involved 186 diagnosed between 1995 2015 their relatives who underwent genetic counseling testing. The rate was estimated with joinpoint regression analysis. Genomic DNA isolated, exons 10, 11, 13, 14, 15, 16 proto-oncogene were amplified polymerase chain reaction. Point mutations gene detected by...
Influence of magnesium sulphate infusion before total thyroidectomy on transient hypocalcemia — a randomised studyBackground. Transient is the most common complication after thyroidectomy. Normomagnesemia needed for normal secretion PTH and end-organ responsiveness. Our aim was to determine influence incidence laboratory clinical hypocalcemia.Methods. In our prospective study, 48 patients (5 men, 43 women; age 22-73 years, median 45 years), who underwent or near-total thyroidectomy, were...
Abstract Background Two high-risk genes have been implicated in the development of CM (cutaneous melanoma). Germline mutations CDKN2A gene are found < 25% melanoma-prone families and there only seven with mutation CDK4 reported to date. Beside those high penetrance genes, certain allelic variants MC1R modify risk developing disease. The aims our study were: determine prevalence germline members familial patients multiple primary CM; search for possible mutations, frequency variations...
PurposeElectrochemotherapy is increasingly entering into national and international guidelines, requiring formal evaluation of treatment costs cost-effectiveness to ensure that its uptake provides value budget-constrained health care systems. This study analyzed the early electrochemotherapy in patients with Stage IIIc/IV skin melanoma clinical practice Slovenia. The were compared those standard care, consisting palliative therapy for symptoms.MethodswThe enrolled 23 treated at Institute...