A5102845607- Cancer-related molecular mechanisms research
- Phytoestrogen effects and research
- Adipose Tissue and Metabolism
- Nutrition, Health and Food Behavior
- Muscle Physiology and Disorders
- Food Industry and Aquatic Biology
- Genetic and phenotypic traits in livestock
- Circular RNAs in diseases
- Reproductive Physiology in Livestock
- Circadian rhythm and melatonin
- Animal Nutrition and Physiology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- RNA modifications and cancer
- Neuroendocrine regulation and behavior
- MicroRNA in disease regulation
- Muscle metabolism and nutrition
- Gout, Hyperuricemia, Uric Acid
- Ruminant Nutrition and Digestive Physiology
- Lipid metabolism and biosynthesis
- Stress Responses and Cortisol
- Molecular Biology Techniques and Applications
- Gut microbiota and health
- PI3K/AKT/mTOR signaling in cancer
- Avian ecology and behavior
- Congenital heart defects research
Hunan Agricultural University
2023-2025
Ministry of Agriculture and Rural Affairs
2024-2025
Zhongkai University of Agriculture and Engineering
2022-2025
Yueyang Changling Equipment Research Institute (China)
2024
Key Laboratory of Guangdong Province
2022
This study sought to understand the regulation mechanism of OPN5 through TSH-DIO2/DIO3 pathway mediated photoperiod on breeding activity short-day birds. In this study, reproductive Magang goose was regulated by artificial light, and ganders were determined according daily laying rate female geese. The testicular development serum hormone concentrations measured during period (d 0), degeneration 13 27) resting 45). mRNA protein expression patterns OPN5, HPG axis genes, related genes...
The growth and development of the Longissimus Dorsi muscle are complex, playing an important role in determination pork quality. study at mRNA level is particularly crucial for finding molecular approaches to improving meat quality pig breeding. current utilized transcriptome technology explore regulatory mechanisms intramuscular fat (IMF) deposition three core developmental stages (natal stage on day 1, growing 60, finishing 210) Ningxiang pigs. Our results revealed 441 differentially...
The processes of muscle growth and development, including myoblast proliferation, migration, differentiation, fusion, are modified by a variety regulatory factors. MYL4 plays an important role in atrial cardiomyopathy, muscle-fiber size, development. structural variation (SV) was found via the de novo sequencing Ningxiang pigs, existence SV verified experiments. genotype distribution pigs Large White detected, it that were mainly BB AB genotype. However, molecular mechanisms behind...
Introduction: The development of skeletal muscle is regulated by regulatory factors genes and non-coding RNAs (ncRNAs). Methods: objective this study was to understand the transformation fiber type in longissimus dorsi male Ningxiang pigs at four different growth stages (30, 90, 150, 210 days after birth, n = 3) histological analysis whole transcriptome sequencing. Additionally, investigated expression patterns various involved constructed a network for competing endogenous RNA (ceRNA) that...
MicroRNAs (miRNAs) are endogenous small non-coding RNAs that play crucial regulatory roles in many biological processes, including the growth and development of skeletal muscle. miRNA-100-5p is often associated with tumor cell proliferation migration. This study aimed to uncover mechanism myogenesis. In our study, we found expression level was significantly higher muscle tissue than other tissues pigs. Functionally, this shows miR-100-5p overexpression promotes inhibits differentiation C2C12...
Photoperiod is an important environmental factor that influences seasonal reproduction behavior in birds. Birds translate photoperiodic information into neuroendocrine signals through deep brain photoreceptors (DBPs). OPN5 has been considered candidate DBPs involved regulating We found could mediate light to regulate the follicle development ducks. In this study, we further verified effect of on follicular Shan Partridge ducks by immunizing against extracellular domain (ECD) OPN5....
The Ningxiang pig, a distinguished local breed in China, is recognized for its good meat quality traits. This study examines the proteomics of pigs at three developmental stages and delves into upstream transcriptomics these proteomics. Such an analysis facilitates deeper understanding molecular interplay between proteins transcriptomes pig muscle, influencing muscle growth development. In this research, we analyzed muscles stages: 30 days weaned piglets, 90 nursery pigs, 210 late fattening...
To investigate the regulatory mechanism mediated by hypothalamic OPN5 on seasonal changes in reproductive activities of domestic geese, 60 Magang ganders their breeding period were selected for experiment and evenly divided into an immunization group(OPN5-IM) a control group. On days 0, 15 30, immunized group with OPN5-KLH protein vaccine, same amount blank emulsified vaccine. Additionally, 120 female geese provided to stimulate male geese. The results showed that arrangement spermatogenic...
Background: Crossbreeding strategies that combine the growth performance of Western pig breeds with meat quality traits Chinese indigenous have garnered considerable interest. Duroc pigs are known for their high efficiency but relatively low intramuscular fat (IMF) content. In contrast, native like Diannan Small-Eared exhibit superior pork higher IMF levels. This study aimed to compare muscle characteristics and molecular mechanisms between × Landrace Yorkshire (DLY) Berkshire (DBD) pigs....
Abstract Background Domestic geese are seasonal breeders and have the lowest reproductive capacity among all poultry species. Magang is a topical short-day breeder, short photoperiod exposure stimulates its activity while long inhibits. To explore epigenetic change that could influence activity, we performed whole genome bisulfite sequencing transcriptome in hypothalamus at three stages during long-light male geese. Results A total number of 10,602 differentially methylated regions (DMRs)...
Muscle cell growth plays an important role in skeletal muscle development. Circular RNAs (circRNAs) have been proven to be involved the regulation of and In this study, we explored effect circTTN on myoblast its possible molecular mechanism. Using C2C12 cells as a functional model, authenticity was confirmed by RNase R digestion Sanger sequencing. Previous studies showed that overexpression inhibits proliferation differentiation. Mechanistically, recruits PURB protein Titin (TTN) promoter...
Both hypothalamic neurotransmitters and serum steroid hormones are impacted by photoperiod have effects on physiology seasonal reproductive. However, the relationship between circulating gonadal steroids underlying different is still unclear. To further understand crosstalk of in reproduction, metabolic changes 27 concentrated hypothalamus tissues 42 were assessed during two artificial photoperiodic programs. The results showed that induce testicular atrophy recrudescence. In L-to-S groups,...
Photoperiod is an important environmental factor that influence seasonal reproduction behavior in bird. Birds translates photoperiodic information into neuroendocrine signals through deep brain photoreceptors (DBPs). OPN5 has been considered as candidate DBPs involving regulation of birds. However, little known about the effect non-seasonal breeding Thus, we pondered on whether regulating follicular development TSH-DIO2/DIO3 system responds to different photoperiods laying ducks. As ideal...
Stocking density critically affects the growth and subsequent performance of animals in modern poultry production. This study investigated effects stocking on ovarian development, maturation, mRNA expression key genes reproductive axis during rearing period Shan-ma ducks. The experiments involved 180 healthy 7-wk-old ducks randomly divided into low (LSD; n = 30, 5 birds/m2), medium (MSD; 60, 10 birds/m2) high groups (HSD; 90, 15 for rearing. After examining development measuring hormone...
Stocking density (SD) is an important issue in the poultry industry, which related to production performance, intestinal health and immune status. In present study, effects of SD on metabolism homeostasis uric acid as well functions liver kidney ducks were examined.
Gut microbial composition and its metabolites are crucial for livestock production performance. Metabolite profiles from autopsied biospecimens provide vital information on the basic mechanisms that affect overall health traits in animals. However, role of host breed gut microbiome fecal metabolome commercial pigs remains unclear. In this work, differences microbiota among three pig breeds Duroc, Yorkshire, Landrace were measured by 16S rRNA gene sequencing. Fecal metabolite compositions...
Meat and its derivatives serve as crucial sources of protein, vitamins, minerals, other essential nutrients for humans. Pork stands China’s primary animal-derived food product consumed widely across diverse dietary structures; evaluating intramuscular fat content becomes pivotal in assessing quality standards. Nonetheless, the intricate molecular mechanisms governing deposition remain elusive. Our study utilized sequencing technology to scrutinize longitudinal development stages within...
Abstract Background: Avian gout is a common metabolic disease characterized by hyperuricemia and urate deposits in the joints, it caused overproduction of uric acid hepatic metabolism or renal underexcretion. However, effects stocking density on are unknown. In present study, homeostasis as well related functions liver kidney ducks were examined. A total 180 healthy 56-day-old Shan-ma randomly divided into low (LSD; n = 30, 5 birds/m 2 ), medium (MSD; 60, 10 ) high groups (HSD; 90, 15 )....