A5101765572- Intracerebral and Subarachnoid Hemorrhage Research
- Adipose Tissue and Metabolism
- Muscle Physiology and Disorders
- Cerebrovascular and Carotid Artery Diseases
- Neurosurgical Procedures and Complications
- Cancer-related molecular mechanisms research
- Epilepsy research and treatment
- Muscle metabolism and nutrition
- Medical Research and Treatments
- Alzheimer's disease research and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Eicosanoids and Hypertension Pharmacology
- Parkinson's Disease Mechanisms and Treatments
- Immune cells in cancer
- Pediatric health and respiratory diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Regional Development and Environment
- Pharmacological Effects and Toxicity Studies
- Molecular Biology Techniques and Applications
- Neonatal and fetal brain pathology
- Forensic and Genetic Research
- Uterine Myomas and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- IL-33, ST2, and ILC Pathways
Ministry of Agriculture and Rural Affairs
2025
Hunan Agricultural University
2022-2025
First Affiliated Hospital of Henan University
2015-2023
Henan University
2015-2022
University of Hawaiʻi at Mānoa
2022
Johns Hopkins Medicine
2015-2021
Johns Hopkins University
2015-2021
Cixian People's Hospital
2013
Inflammatory responses mediated by prostaglandins such as PGE 2 may contribute to secondary brain injury after intracerebral hemorrhage (ICH). However, the cell-specific signaling receptor EP2 differs depending on whether neuropathic insult is acute or chronic. Using genetic and pharmacologic approaches, we investigated role of in two mouse models ICH induced intrastriatal injection collagenase autologous arterial whole blood. We used middle-aged male mice enhance clinical relevance study....
Objective To evaluate the correlation of serum biological markers and related scales to occurrence delayed cerebral ischemia clinical prognosis in patients with aneurysmal subarachnoid hemorrhage (aSAH) complicated acute hydrocephalus before admission. Methods The data 227 pre-admission aSAH admitted Henan Provincial People's Hospital from April 2017 December 2020 were retrospectively analyzed. Patients grouped according presence or absence (DCI) after surgery at 6 months discharge....
In recent years, Graph Neural Networks (GNNs) based on deep learning techniques have achieved promising results in EEG-based depression detection tasks but still some limitations. Firstly, most existing GNN-based methods use pre-computed graph adjacency matrices, which ignore the differences brain networks between individuals. Additionally, graph-structured data do not consider temporal dependency information of networks. To address these issues, we propose a algorithm that explores adaptive...
The Ningxiang pig, a distinguished local breed in China, is recognized for its good meat quality traits. This study examines the proteomics of pigs at three developmental stages and delves into upstream transcriptomics these proteomics. Such an analysis facilitates deeper understanding molecular interplay between proteins transcriptomes pig muscle, influencing muscle growth development. In this research, we analyzed muscles stages: 30 days weaned piglets, 90 nursery pigs, 210 late fattening...
Background: Crossbreeding strategies that combine the growth performance of Western pig breeds with meat quality traits Chinese indigenous have garnered considerable interest. Duroc pigs are known for their high efficiency but relatively low intramuscular fat (IMF) content. In contrast, native like Diannan Small-Eared exhibit superior pork higher IMF levels. This study aimed to compare muscle characteristics and molecular mechanisms between × Landrace Yorkshire (DLY) Berkshire (DBD) pigs....
Uterine leiomyosarcoma (ULMS) is an aggressive form of soft tissue tumors. The molecular heterogeneity and pathogenesis ULMS are not well understood.Expression profiling data were used to determine the possibility optimal number subtypes. Next, clinicopathological characters pathways analyzed in each subtype prospect clinical applications progression mechanisms ULMS.Two distinct subtypes defined based on different gene expression signatures. Subtype I recapitulated low-grade ULMS, pattern...
The Brangus cattle were developed to utilize the superior traits of Angus and Brahman cattle. Their genetic compositions are expected be stabilized at 3/8 5/8 Angus. Previous studies have shown more than lineage with cattle, reasons yet investigated. In this study, we revisited breed for 3,605 from three perspectives: genome-wise (GBC), per chromosomes (CBC), chromosome segments (SBC). former (GBC) depicted an overall picture “mosaic” genome attributable their ancestors, whereas latter two...
Serum levels of β-amyloid (A) peptides may represent an early biomarker in the diagnosis Alzheimer's disease (AD). In present study, we investigated temporal kinetic changes serum Aβ 1-42 and 40 amyloid precursor protein (APP)/presenilin (PS)1 double transgenic mouse model AD. peptide 2-, 3-, 6-, 9- 18-month old, liver 1-40 level 6-month old mice were measured using enzyme-linked immunosorbent assay (ELISA) kits. Results revealed that peaked 3-month mice, non-transgenic is comparable liver....
The Solitaire AB stent is one of many assistant stents used for treating wide-necked cerebral aneurysm, and has been since 2003. However, large sample studies on its safety effectiveness are lacking. objective this study was to evaluate the in coil embolization aneurysms.Retrospective review clinical image data 116 patients with aneurysms who had enrolled at six interventional neuroradiology centers from February 2010 2014 treated by embolization; total, 120 were used. degree aneurysm...
Background: There have been many studies on the relationship between circRNAs and fat deposition. Although liver is a central organ for metabolism, there are few reports in Methods: In this study, we systematically analyzed circular RNAs of Ningxiang pigs, at four time points after birth (30 days, 90 150 days 210 days). Results: A total 3705 were coexpressed periods found, KEGG analysis showed that significantly upregulated pathways mainly enriched lipid metabolism amino acid while...
<title>Abstract</title> Mounting evidence indicates that a variety of functional genes can significantly affect the progression inflammatory bowel disease (IBD); nevertheless, association between monoamine oxidase A (MAOA) and clinical features IBD remains unclear. Here we demonstrated <italic>MAOA</italic> was negatively correlated with through GEO datasets single-cell RNA-Seq online database. This may be epithelial plays major role. Then verified involved in changes drug energy metabolism...
Introduction: Microglia become activated and monocytes macrophages following intracerebral hemorrhage (ICH). They are often called “microglia/macrophage” since it is difficult to differentiate between them. The neutrophils also infiltrate into the injured brain after ICH. Those cells capable of releasing numerous detrimental mediators. Hypothesis: activation microglia/macrophage infiltrated promote injury ICH that inhibition both them attenuates Methods: 10-μl autologous blood obtained from...
Objective To investigate the electroclinical, treatment response and prognosis of juvenile absence epilepsy (JAE). Methods Thirty-two patients diagnosed as JAE from Epilepsy Center Xijing Hospital between January 2014 August 2017 were investigated. All them underwent 24-hour video-electroencephalography(EEG) recording. Clinical aspects, electroencephalographic features, antiepileptic drugs (AEPs) received reviewed. The follow-up time was 6-44 months, with an average (18.6±11.6)...