A5094140803- Child Nutrition and Feeding Issues
- Childhood Cancer Survivors' Quality of Life
- Cystic Fibrosis Research Advances
- Clinical Nutrition and Gastroenterology
- Intestinal Malrotation and Obstruction Disorders
- Organ Donation and Transplantation
- Central Venous Catheters and Hemodialysis
- Adolescent and Pediatric Healthcare
- Mechanical Circulatory Support Devices
- Liver Diseases and Immunity
- Organ Transplantation Techniques and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Dialysis and Renal Disease Management
- Drug Transport and Resistance Mechanisms
- Liver Disease and Transplantation
University Children's Hospital Tübingen
2024-2025
University of Tübingen
2024
Exocrine pancreatic insufficiency in cystic fibrosis (CF) increases fecal choline losses, but the postnatal course of plasma and its metabolites these patients is unknown. While homeostasis crucial for cellular, bile, lipoprotein metabolism, via phosphatidylcholine (PC) betaine as a methyl donor, deficiency associated with impaired lung liver function, including hepatic steatosis. The goal our study was to evaluate levels choline, betaine, trimethylamine oxide (TMAO), PC, PC subclasses CF...
Abstract Background and Aims Life expectancy for patients with chronic intestinal failure (CIF) recieving home parenteral nutrition (HPN) has improved over the past decades. Consequently, more children on HPN grow into adulthood. Until now, no assessment of transition readiness these exists. Aim is to assess adolescents HPN. Methods This an international, prospective, cross‐sectional multicenter study in collaboration members Intestinal Failure working group—European Reference Network Rare...
Background: Exocrine pancreatic insufficiency in Cystic Fibrosis (CF) increases fecal choline losses, but the postnatal course of plasma and its metabolites these patients is un-known. While homeostasis crucial for cellular, bile, lipoprotein metabolism, via phosphatidylcholine (PC) betaine as a methyl donor, deficiency associated with impaired lung liver function, including hepatic steatosis. Objective: To assess levels choline, betaine, trimethylamine oxide (TMAO), PC, PC subclasses CF...
Background: Sufficient choline supply is essential for tissue functions via phosphatidylcholine and sphingomyelin within membranes secretions like bile, lipoproteins surfactant, in one-carbon metabolism betaine. Choline requirements are linked to age genetics, folate cobalamin betaine, arachidonic (ARA) docosahexaenoic (DHA) acid transport the moiety of lipoproteins. Groups at risk deficiency include preterm infants, children with cystic fibrosis (CF) patients dependent on parenteral...
Abstract Objectives Paediatric acute liver failure (PALF) is a life‐threatening disease. Management aims to support hepatic regeneration or bridge transplantation. High‐volume plasmapheresis (HVP) removes protein‐bound substances, alleviates inflammation, and improves survival in adult failure. However, experience with HVP PALF limited. Aim of this study report on feasibility, safety, efficacy outcomes PALF. Methods Retrospective observational children was performed upon identification...
Abstract Objectives Paediatric patients with intestinal failure (IF) are at risk for both gastrointestinal (GI) and systemic complications, thus depending on a functioning network of multidisciplinary care. Data the clinical impact coronavirus disease 2019 (COVID‐19) or pandemic‐related restrictions limited. We aimed to analyse course COVID‐19 in children IF, evaluate perceived pandemic IF their caregivers by analysing quality life (QoL), health‐related QoL (HRQoL) health Methods Children...
Background & Aims Children with chronic intestinal failure (IF) require a long-term central venous catheter (CVC) for provision of parenteral nutrition. Vascular, mechanical and infectious complications such as line-associated bloodstream infections (CLABSI) may lead to progressive loss access sites. Handling management CVCs therefore play an important role. Our vascular rehabilitation concept (VRC) is core component our program (IRP) consists education program, optimization skin care,...
Background: Patients with progressive familial intrahepatic cholestasis (PFIC) experience cholestasis-associated symptoms, including severe pruritus. Odevixibat is an ileal bile acid transporter inhibitor indicated for treatment of PFIC in the European Union and pruritus United States. The aim current study was to characterize real-world effectiveness safety odevixibat patients PFIC. Methods: This retrospective included 9 treated a single center Tübingen, Germany. Data were recorded using...