A5074001935- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gut microbiota and health
- Pharmacological Effects of Medicinal Plants
- Genomic variations and chromosomal abnormalities
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Colorectal Cancer Screening and Detection
- Nigella sativa pharmacological applications
- Saffron Plant Research Studies
- Eosinophilic Esophagitis
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Treatments and Studies
- Probiotics and Fermented Foods
Howard University
2023-2024
The maintenance of DNA sequence integrity is critical to avoid accumulation cancer-causing mutations. Inactivation Mismatch Repair (MMR) genes (e.g., MLH1 and MSH2) common among many cancers, including colorectal cancer (CRC) the driver classic microsatellite instability (MSI) in tumors. Somatic MSH3 alterations have been linked a specific form MSI called elevated at selected tetranucleotide repeats (EMAST) that associated with patient poor prognosis African American (AA) rectal patients....
Abstract Background: Colorectal cancer (CRC) incidence and mortality in African Americans (AA) is higher compared to Caucasians (CAU). It has also been reported that the disparity due differences mutation spectrum particularly germline mutations DNA mismatch repair (MMR) genes (such as hMSH6). Aim: We aimed determine MSH6 profile AAs with CRC. Methods: performed RNA sequencing 8 paired CRC samples (AA, n=4 CAU, n=4) identify unique transcript novel pathogenic AA CAU by comparing matched...
Abstract Background: Unique mutations in cancer genes have been found different races including African Americans (AA) population. Maintenance of proficient mismatch repair is important colorectal cancer. Among them, MSH3 to be more AA particularly as its alterations associate with EMAST phenotype that has poor prognosis. However, there are regional variations the classification and criteria used determine pathogenicity these due their high genomic diversity. Aim: To analyze unique novel...
The prevalence of Barrett's esophagus (BE) in African Americans (AA) is uncertain. However, several potential risk factors, includes family history, male sex, ethnicity, chronic heartburn and acid reflux, age over 60, current or past smoking, obesity are associated with BE. aim this study to determine the incidence BE AA patients who underwent Esophageal Gastro Endoscopy (EGD).Medical demographic data 1,253 various symptoms, including BE, adenocarcinoma (EAC), esophageal squamous (SCC),...