A5045373092- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Sleep and related disorders
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Electromagnetic Fields and Biological Effects
- Anesthesia and Neurotoxicity Research
- Neurological Disease Mechanisms and Treatments
- Nausea and vomiting management
- Folate and B Vitamins Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Nutrition and Health in Aging
- Spaceflight effects on biology
- Iron Metabolism and Disorders
Peking University
2020-2024
Peking University Third Hospital
2020-2024
First Affiliated Hospital Zhejiang University
2024
Hebei University of Technology
2017
Abstract Background Postoperative sleep disorder (PSD) and delirium, which may be associated with surgery inhalational anesthetics, induce adverse effects in old adults. Emerging evidence indicates that circadian rhythm contributes to various neuropathological diseases, including Alzheimer's disease. Thus, we analyzed the potential role of PSD delirium‐like behavior aged mice determined whether exogenous melatonin could facilitate entrainment after laparotomy under sevoflurane anesthesia....
Postoperative cognitive dysfunction (POCD) is commonly observed during the postoperative period and significantly affects prognosis of patients. Neuroinflammation plays a vital role in pathogenesis POCD. Despite laboratory clinical research over past decades, practical pharmacological strategies for treatment prevention POCD are not yet available currently. Nobiletin (NOB) natural polymethoxylated flavone. As an enhancer clock protein retinoic acid receptor-related orphan receptors (RORs),...
Post-operative sleep disorders induce adverse effects on patients, especially the elderly, which may be associated with surgery and inhalational anaesthetics. Melatonin is a neuroendocrine regulator of sleep-wake cycle. In this study, we analysed alterations post-operative in aged melatonin-deficient (C57BL/6J) mice, investigated if exogenous melatonin could facilitate entrainment circadian rhythm after laparotomy under sevoflurane anaesthesia. The results showed that anaesthesia had greater...
<title>Abstract</title> <bold>Introduction:</bold> Propofol may induce emotional impairment like euphoria and elation. Previous studies have demonstrated that can injure social cognition emotion recognition decision-making abilities. Therefore, this study is designed to investigate the effects of propofol anesthesia on facial (FER) delay discounting behavior. <bold>Method: </bold>Patients underwent diagnostic gastrointestinal endoscopy (GI) with in prospective cohort observational study....
Background: To investigate the relationship between red blood cell (RBC) folate and congestive heart failure (CHF). Methods: We extracted concentrations of RBC collated CHF information from National Health Nutrition Examination Survey (NHANES) survey (12820 individuals). Weighted univariate logistic regression, weighted multivariate restrictive cubic spline (RCS) were used to assess CHF. Results: The unadjusted model showed that highest tertile group concentration was significantly...
Postoperative sleep disorder and delirium, which may be associated with surgery inhalational anesthetics, induce adverse effects in patients, especially older adults. Emerging evidence indicates that the circadian rhythm contributes to various neuropathological diseases, including Alzheimer's disease. In present study, we analyzed potential role of pathophysiological processes postoperative delirium-like behavior aged mice determined whether exogenous melatonin could facilitate entrainment...
Objective: To investigate the influence of extremely low-frequency magnetic field on periodical expression cryptochrome (Cry) gene in mouse embryonic fibroblast NIH3T3 cells. Methods: The cells were divided into group and sham-exposure group. stimulated by horse serum then exposed to an (50 Hz 0.3 mT) for 48 hours, those also a coil hours. collected, total RNA was extracted, cDNA obtained via reverse transcription. Real-time fluorescent quantitative RT-PCR used measure changes transcription...