A5101911811- Cancer-related Molecular Pathways
- Advanced Sensor and Control Systems
- Advanced Algorithms and Applications
- Advanced Computational Techniques and Applications
- Chemical Synthesis and Analysis
- Technology Adoption and User Behaviour
- Industrial Technology and Control Systems
- Evaluation and Optimization Models
- Multicomponent Synthesis of Heterocycles
- Outsourcing and Supply Chain Management
- Digital Platforms and Economics
- Innovation Diffusion and Forecasting
- Optical measurement and interference techniques
- Image and Object Detection Techniques
- Neural Networks and Applications
- Advanced Decision-Making Techniques
- Glioma Diagnosis and Treatment
- Toxic Organic Pollutants Impact
- Information Technology Governance and Strategy
- Synthesis and biological activity
- Fault Detection and Control Systems
- Ocean Acidification Effects and Responses
- Big Data and Business Intelligence
- Privacy, Security, and Data Protection
- Customer Service Quality and Loyalty
Nanchang University
2023-2025
University of Electronic Science and Technology of China
2025
Zhejiang University
2024
AviChina Industry & Technology (China)
2023
Tianjin University
2023
Lanzhou University
2022
Huashan Hospital
2021
Fudan University
2020-2021
Beijing University of Posts and Telecommunications
2007-2020
Pudong Medical Center
2020
As a member of Sirtuins family, SIRT6 participates in the physiological and pathological progress DNA repair, anti-aging, metabolism, so on. Several studies have demonstrated that knockdown inhibited development atherosclerosis (AS), indicated as protective factor for AS. However, we confirmed was significantly overexpressed human unstable carotid plaques compared with stable plaques. This result more complex role Furthermore, constructed mice model plaque injected them adeno-associated...
Cancer stem cells play a central role in the pathogenesis of nasopharyngeal carcinoma and contribute to both disease initiation relapse.In this study, cyclooxygenase-2 (COX-2) was found regulate cancer stem-like side population enhance cells' characteristics such as higher colony formation efficiency overexpression stemness-associated genes.The regulatory effect COX-2 on may be mediated by ABCG2.COX-2 gain-of-function experiment increased proportion their stemness properties.The present...
Malignant gliomas are one of the leading causes cancer deaths worldwide, but chemoprevention strategies for them few and poorly investigated. Here, we show that cholera toxin, traditional biotoxin well known inducer accumulation cellular cAMP, is capable inducing differentiation on malignant in vitro with rat C6 primary cultured human glioma cells. Cholera toxin-induced was characterized by typical morphological changes, increased expression glial fibrillary acid protein, decreased Ki-67,...
Overstimulation of NMDA-type glutamate receptors is believed to be responsible for neuronal death the CNS in various disorders, including cerebral and spinal cord ischemia. However, intrinsic physiological mechanisms modulation these are essentially unknown. Here we report that cholestane-3β,5α,6β-triol (triol), a major metabolite cholesterol, an endogenous neuroprotectant protects against injury both vitro vivo via negative NMDA receptors. Treatment cultured neurons with triol...
The inhibition of p53-MDM2 interaction is a promising new approach to non-genotoxic cancer treatment. A potential application for drugs blocking the acute myeloid leukemia (AML) due occurrence wild type p53 (wt p53) in majority patients. Although there are very preclinical results several antagonists early development, none compounds have yet proven utility as next generation anticancer agent. Herein we report design, synthesis and optimization YH239-EE (ethyl ester free carboxylic acid...
Based on the logic of job demands-resources model, we argue that work-related factors demand workers' resources, such as overload and organizational constraints, may lead to work–family conflict through emotional exhaustion. Other generate resources for workers, autonomy task significance, facilitation satisfaction. Analyzing survey data collected from different sources among professional nurses in Taiwan, use structural equation modeling technique find support our hypotheses. Our study...
Abstract Objective The aim of the study was to analyze self-monitoring ankle impedance measuring instrument for patients with heart failure and evaluate degree variation in normal young people three days. Methods We developed a portable based on AD5940 chip ADI. circuit composed programmable alternating current (AC) voltage generator, digital signal processor, microcontroller, related peripheral circuits. four-line body analysis measurement method used, which powered by two 1.5-V batteries,...
A series of 9,9′-bifluorenylidene derivatives demonstrate orthogonalization non-conducting (between radical sites) and conducting thiomethyl groups) paths. Precise injections significantly reduce single-molecule conductance.
On the basis of our recently resolved first cocrystal structure Mdm4 in complex with a small molecule inhibitor (PDB ID 3LBJ), we devised an approach for generation potential selective ligands. We performed Ugi four-component reaction (Ugi-4CR) 96-well plates indole fragment, which is specially designed to mimic Trp23, key amino acid interaction between p53 and Mdm4. Generally yielded mostly precipitates collected by filter plates. The best hit compound was found be active (Ki = 5 μM,...
Abstract The compstatin family of complement inhibitors has shown promise in various immuno‐inflammatory disorders. Although recent analogues show beneficial pharmacokinetics, further extension the plasma half‐life is expected to benefit systemic application these peptidic inhibitors. We therefore synthesized conjugates and albumin‐binding molecules (ABM) increase circulatory residence. Equilibrium dialysis complement‐depleted serum showed a marked protein binding from <8 % >99 for...
Abstract Personalized recommendation services have been widely applied to improve users’ search efficiency, but when filtering information for users, they also hide the risk of declining in content diversity, which is narrowing. In this study, comprehensive news and platforms China were taken as empirical research object. The experimental tracking method was used collecting data client end recommended news. Simpson Shannon-Wiener indexes measure narrowing phenomenon. Questionnaires collect...
As mobile payment will get and use personal information of users to complete the process, which may generate problems users' privacy stolen, leaked, improperly used, bringing about concern on privacy. This paper uses structural equation model analyze impact intention payment. The results show that has significant effects perceived risk trust, indirectly affects usage through trust. Mobile service providers should take effective measures alleviate in order reduce their perception enhance...
For B2C e-commerce enterprises, it is of great importance to select the third-party logistics (3PL) providers. The paper, focused on concept “logistics capability”, took full account characteristics and its service referred research findings scholars. As a result, six dimensions, evaluation indexes 3PL providers' capability in mode were identified. Besides, Case studies conducted with multi-index decision methods based Relative Approximation, showing that final results are reliable.