A5022090642- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Virus-based gene therapy research
- Cancer Research and Treatments
- T-cell and B-cell Immunology
- Neuroblastoma Research and Treatments
Dana-Farber Cancer Institute
2022-2024
Harvard University
2022-2024
Acute myeloid leukemia (AML) remains a therapeutic challenge, and paucity of tumor-specific targets has significantly hampered the development effective immune-based therapies. Recent paradigm-changing studies have shown that natural killer (NK) cells exhibit innate memory upon brief activation with IL-12 IL-18, leading to cytokine-induced memory-like (CIML) NK cell differentiation. CIML enhanced antitumor activity promising results in early phase clinical trials patients relapsed/refractory...
Epithelial ovarian cancer (EOC) remains one of the most lethal gynecological cancers. Cytokine-induced memory–like (CIML) natural killer (NK) cells have shown promising results in preclinical and early-phase clinical trials. In current study, CIML NK demonstrated superior antitumor responses against a panel EOC cell lines, increased expression activation receptors, up-regulation genes involved cycle/proliferation down-regulation inhibitory/suppressive genes. transduced with chimeric antigen...
<title>Abstract</title> Given the safety, tumor tropism, and ease of genetic manipulation in non-pathogenic <italic>Escherichia coli</italic> (<italic>E. coli</italic>), we designed a novel approach to deliver biologics overcome poor trafficking exhaustion immune cells microenvironment, via surface display key immune-activating cytokines on outer membrane <italic>E. K-12 DH5α. Bacteria expressing murine decoy-resistant IL18 mutein (DR18) induced robust CD8<sup>+</sup> T NK cell-dependent...
Abstract Despite the major advances, cancer patients treated with targeted chimeric antigen receptor (CAR)- based T and NK cell therapies often face challenge of frequent disease relapse, their efficacy in solid tumors is low. This attributed to inherent potency starting material, unique characteristics CAR engineering resulting trogocytosis tonic signaling, notable absence homogenously expressed surface markers, particularly tumors. To address these limitations, we engineered a novel...
Abstract Epithelial ovarian cancer (OVC) is the leading cause of death among gynecological malignancies. Natural killer (NK) cells are an attractive platform for immunotherapy owing to their superior safety, multiple mechanisms cytotoxicity, and reduced risk alloreactivity. Recently, paradigm-shifting studies have shown that brief activation NK with inflammatory cytokines induces differentiation into cytokine induced memory-like (CIML) feature. CIML demonstrated potent activity in...
Abstract Epithelial ovarian cancer (OVC) is the leading cause of death among gynecological malignancies. Natural killer (NK) cells are an attractive platform for immunotherapy owing to their superior safety, multiple mechanisms target killing, and reduced risk alloreactivity. Recently, paradigm-shifting studies have shown that brief activation NK with inflammatory cytokines induces differentiation into cytokine induced memory-like (CIML) cells. CIML demonstrated potent anti-leukemia activity...