A5043330042- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Hearing, Cochlea, Tinnitus, Genetics
- Cellular Mechanics and Interactions
- Corneal surgery and disorders
- Hearing Loss and Rehabilitation
- Bone Tissue Engineering Materials
- Ear Surgery and Otitis Media
- Antimicrobial Peptides and Activities
- Cancer-related Molecular Pathways
- Nerve injury and regeneration
- TGF-β signaling in diseases
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Retinopathy of Prematurity Studies
- Advanced Drug Delivery Systems
- Dendrimers and Hyperbranched Polymers
- Biocrusts and Microbial Ecology
- Kruppel-like factors research
- Neuroscience of respiration and sleep
- Neurobiology and Insect Physiology Research
- Vestibular and auditory disorders
- NF-κB Signaling Pathways
- Protease and Inhibitor Mechanisms
- Bioactive Natural Diterpenoids Research
Deakin University
2025
University of Washington
2007-2011
University of Wisconsin–Madison
1997-2006
The basement membrane possesses a rich 3-dimensional nanoscale topography that provides physical stimulus, which may modulate cell-substratum adhesion. We have investigated the strength of adhesion on topographic features similar scale to native membrane. SV40 human corneal epithelial cells were challenged by well-defined fluid shear, and cell detachment was monitored. created silicon substrata with uniform grooves ridges having pitch dimensions 400-4000 nm using X-ray lithography. F-actin...
Abstract The cornea is a complex tissue composed of different cell types, including corneal epithelial cells and keratocytes. Each these types are directly exposed to rich nanoscale topography from the basement membrane or surrounding extracellular matrix. Nanoscale has been shown influence behaviors, orientation, alignment, differentiation, migration, proliferation. We investigated whether proliferation SV40‐transformed human (SV40‐HCECs), primary (HCECs), fibroblasts influenced by scale...
Cell cycle inhibitors, such as the cyclin-dependent kinase (Cdk) inhibitor proteins and retinoblastoma (Rb) family members, control exit from cell during development of a variety terminally differentiated tissues. It is unclear whether sustained expression these required to prevent re-entry in quiescent cells. The organ Corti (cochlear sensory epithelium) pars intermedia (intermediate lobe pituitary) are two tissues that share characteristic ongoing division mice lacking either p27(Kip1) Cdk...
The effect of surface chemistry on the proliferation and adhesion SV-40 human corneal epithelial cells was investigated. substrates controlled by deposition self-assembled monolayers (SAMs) terminated with following functional groups: -CF3, -CH3, -CO(2)H, -NH(2). SAMs alkanethiols gold alkylsiloxanes SiOx were included in study. Comparisons are made between different types functionalities SAM-covered tissue culture polystyrene. Adhesion assays performed after incubation for 1 h 10% fetal...
This paper reports the results of a study that aimed to identify thermotropic liquid crystals are not toxic mammalian cells. Mesogenic compounds were mixed create eight crystalline phases, each with unique set functional groups. We investigated toxicity phase using two cell lines—3T3 fibroblast and SV-40 transformed human corneal epithelial (HCEC) Using dual fluorescent staining assays based on calcein acetoxymethylester (Calcein-AM) ethidium homodimer, we measured correspondingly number...
Humans and other mammals are highly susceptible to permanent hearing balance deficits due an inability regenerate sensory hair cells lost inner ear trauma. In contrast, nonmammalian vertebrates, such as birds, robustly replacement restore functions near-normal levels. There is considerable interest in understanding the cellular mechanisms responsible for this difference regenerative capacity. Here we report on involvement of TGFbeta superfamily type II activin receptors, Acvr2a Acvr2b,...