A5029494969- Phosphodiesterase function and regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Boron Compounds in Chemistry
- Renin-Angiotensin System Studies
- Immune cells in cancer
- Mitochondrial Function and Pathology
- Cardiac Ischemia and Reperfusion
- Adenosine and Purinergic Signaling
- Ferroptosis and cancer prognosis
- RNA regulation and disease
- GDF15 and Related Biomarkers
- RNA Interference and Gene Delivery
- Advanced Glycation End Products research
- Biochemical effects in animals
- Aquaculture Nutrition and Growth
- Protein Hydrolysis and Bioactive Peptides
- Anesthesia and Neurotoxicity Research
- Nuclear Receptors and Signaling
- Cholinesterase and Neurodegenerative Diseases
- Caveolin-1 and cellular processes
- Nitric Oxide and Endothelin Effects
Southern Medical University
2024-2025
Fourth Hospital of Changsha
2024-2025
Hunan Normal University
2025
We have previously shown that phosphodiesterase 4 (PDE4) inhibition protects against neuronal injury in rats following middle cerebral artery occlusion/reperfusion (MCAO/R). However, the effects of PDE4 on brain edema and astrocyte swelling are unknown. In this study, we showed by Roflumilast (Roflu) reduced water content subjected to MCAO/R. Roflu decreased expression aquaporin (AQP4), while levels phosphorylated protein kinase B (Akt) forkhead box O3a (FoxO3a) were increased. addition,...
Sevoflurane is considered an effective neuroprotector in cerebral ischemia/reperfusion injury (CIRI). preconditioning CIRI, however, remains unknown precisely by its molecular mechanism. The middle artery occlusion reperfusion (MCAO/R) rat model was established, and neurological function evaluated Zea-Longa score. Cerebral water content determined to assess edema. Brain pathological condition observed hematoxylin eosin staining, the intact changes of neurons were Nissl neuronal apoptosis...