A5049406744- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Motor Control and Adaptation
- Multiple Sclerosis Research Studies
- Muscle activation and electromyography studies
- Hereditary Neurological Disorders
- Epilepsy research and treatment
- Mitochondrial Function and Pathology
- Peripheral Neuropathies and Disorders
- Neurological and metabolic disorders
- Advanced Neuroimaging Techniques and Applications
- EEG and Brain-Computer Interfaces
- Stroke Rehabilitation and Recovery
- Vestibular and auditory disorders
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neural Engineering
- Facial Nerve Paralysis Treatment and Research
- Advanced MRI Techniques and Applications
- RNA regulation and disease
- Neurogenetic and Muscular Disorders Research
- Ophthalmology and Eye Disorders
- Trace Elements in Health
Center for Autism and Related Disorders
2024
Children's Hospital of Philadelphia
2024
Temple University
2024
University of Rostock
2004-2015
Klinik und Poliklinik für Neurologie
1999-2015
Universitätsmedizin Rostock
2014-2015
Rostocker Zentrum zur Erforschung des Demografischen Wandels
2004-2009
Glasgow Life
2009
Medical University of Vienna
2000-2009
Norwegian University of Science and Technology
2008
Background and Purpose —We sought to define an effective safe dose of botulinum toxin type A (Dysport) for the treatment upper limb muscle spasticity due stroke. Methods —This was a prospective, randomized, double-blind, placebo-controlled, dose-ranging study. Patients received either placebo or 1 3 doses Dysport (500, 1000, 1500 U) into 5 muscles affected arm. Efficacy assessed periodically by Modified Ashworth Scale battery functional outcome measures. Results —Eighty-three patients were...
We studied the role of remote metabolic depressions and pyramidal tract involvement regarding motor recovery following a first hemiparetic ischemic stroke. In 23 patients regional cerebral glucose metabolism (rCMRGlu) was measured with positron emission tomography location spatial extent stroke lesions were assessed by magnetic resonance imaging. Motor impairment during acute chronic stages (4 weeks after stroke) determined score recordings evoked potentials. Twelve recovered significantly,...
A new botulinum toxin type free of complexing proteins (NT 201) was compared with BOTOX in patients cervical dystonia by means a double-blind noninferiority trial. Four hundred sixty-three received IM injections 70 to 300 U NT 201 or and were followed up over 16 weeks. The study clearly shows that is at least as effective safe BOTOX.
Investigation of motor function in a group 17 patients with Huntington's disease reveals that, addition to the chorea that many exhibit, defects voluntary performance also are evident. Fast simple wrist flexion movements 15° or 60° were slower, and individual showed greater variability than seen normal subjects. This bradykinesia was most pronounced those who akinetic rigid, but alone; independent drug treatment receiving (and therefore not due drug-induced parkinsonism). The...
To study the use of brain parenchyma sonography (BPS) in discriminating between patients with idiopathic PD (IPD) and atypical parkinsonian syndromes (APS).Twenty-five APS, 9 progressive supranuclear palsy (PSP) 16 multiple-system atrophy (MSA), 25 age-matched IPD were prospectively studied BPS according to a standardized protocol.Twenty-four (96%) exhibited hyperechogenicity substantia nigra (SN) but only 2 23 (9%) APS (Mann-Whitney U test, p < 0.001). In those two patients, SN was moderate...
<h3>OBJECTIVES</h3> Botulinum toxin injections have become a first line therapeutic approach in cervical dystonia. Nevertheless, published dosing schedules, responder rates, and frequency of adverse events vary widely. The present prospective multicentre placebo controlled double blind dose ranging study was performed homogenous group previously untreated patients with rotational torticollis to obtain objective data on dose-response relations. <h3>METHODS</h3> Seventy five were randomly...
Substantia nigra (SN) hyperechogenicity is a characteristic transcranial sonography (TCS) finding in idiopathic Parkinson's disease. SN hyperechogenicity, found also approximately 10% of healthy adults, was related to subclinical malfunction the nigrostriatal dopaminergic system on PET studies and is, therefore, thought represent risk marker for Epidemiological findings suggest an increased subjects with depression. To find out whether frequency depression, we performed TCS brainstem basal...
<b>Objective: </b> Leucine-rich repeat kinase 2 (<i>LRRK2</i>) mutations are the most common cause of Parkinson disease (PD). Several dominantly inherited pathogenic substitutions have been identified in different domains Lrrk2 protein. Herein, we characterize clinical and genetic features associated with p.R1441C. <b>Methods: We 33 affected 15 unaffected <i>LRRK2</i> c.4321C>T (p.R1441C) mutation carriers through an international consortium originating from three continents. The...
To investigate whether transcranial brain parenchyma sonography (TCS) detects basal ganglia abnormalities in asymptomatic and symptomatic patients with Wilson disease (WD) findings correlate severity.Twenty-one WD (n = 18) or without 3) neurologic symptoms were investigated. Disease severity was assessed by three independent neurologists using a rating scale (WDRS) the items dysarthria, akinesia, ataxia, tremor, dystonia; raters' median score used for further analysis. Basal TCS performed...
Background and purpose Post‐stroke immunodepression has been related to brain lesion size but not a specific location. Here, we studied the influence of location within middle cerebral artery ( MCA ) territory on parameters activation sympathetic adrenomedullar pathway, immunodepression, associated infection. Methods We analyzed clinical, imaging, laboratory data 384 patients (174 women; mean age 70.8 ± 12.9 years) consecutively admitted stroke unit no later than 24 h after onset acute...
To study the use of brain parenchyma sonography (BPS) in discriminating between patients with corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP).Thirteen PSP eight CBD were studied BPS according to a standardized protocol.Seven (88%) showed marked hyperechogenicity substantia nigra (SN) but none eleven (Mann-Whitney U test, p < 0.001). This finding indicated positive predictive value 100%. Marked dilatation third ventricle (width > 10 mm) was found (83%) 12 patients, (p...