A5094049195- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
University of Helsinki
2024
Helsinki University Hospital
2024
To uncover the intricate, chemotherapy-induced spatiotemporal remodeling of tumor microenvironment, we conducted integrative spatial and molecular characterization 97 high-grade serous ovarian cancer (HGSC) samples collected before after chemotherapy. Using single-cell analyses, identify increasingly versatile immune cell states, which form spatiotemporally dynamic microcommunities at tumor-stroma interface. We demonstrate that chemotherapy triggers redistribution exhaustion CD8+ T cells due...
Abstract Our goal was to characterize the effects of chemotherapy on tumor microenvironment high-grade serous ovarian cancer (HGSC) and suggest effective combination treatment strategies. We employed comprehensive multiomic spatial single-cell profiling techniques, including tissue cyclic immunofluorescence t-CycIF, scRNA sequencing, transcriptomics (GeoMx) a total 70 HGSC samples obtained from 41 patients our prospective, observational trials (DECIDER, ONCOSYS-OVA). The longitudinal were...