A5103072353- Barrier Structure and Function Studies
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Glycosylation and Glycoproteins Research
- S100 Proteins and Annexins
University of California, San Francisco
2012-2024
University College London
2021
Yale University
2001
Florence (Netherlands)
2001
DELL (United States)
2001
We tested the hypothesis that plasma neurofilament light chain (NfL) identifies asymptomatic carriers of familial frontotemporal lobar degeneration (FTLD)-causing mutations at risk disease progression.Baseline NfL concentrations were measured with single-molecule array in original (n = 277) and validation 297) cohorts. C9orf72, GRN, MAPT mutation noncarriers from same families classified by severity (asymptomatic, prodromal, full phenotype) using CDR Dementia Staging Instrument plus behavior...
Identification of fluid biomarkers for progressive supranuclear palsy (PSP) is critical to enhance therapeutic development. We implemented unbiased DNA aptamer (SOMAmer) proteomics identify novel CSF PSP biomarkers.
Since most <i>in vitro</i>studies exploring the action of <i>Clostridium perfringens</i>enterotoxin (CPE) utilize either Vero or CaCo-2 cells, current study directly compared CPE responsiveness those two cell lines. When CPE-treated in suspension, both and cells formed SDS-resistant, CPE-containing complexes ∼135, ∼155, ∼200 kDa. However, confluent Transwell® cultures line for 20 min only ∼155-kDa complex. also exhibited significant<sup>86</sup>Rb release, complex formation is sufficient...
The C ‐terminal cytoplasmic tails of claudins are likely sites for interaction with proteins that regulate their function. We performed a yeast two‐hybrid screen the tail human claudin‐2 against kidney cDNA library and identified interactions PDZ3 domain ZO‐2 as well ubiquitin‐conjugating enzyme E2I (SUMO ligase‐1) E3 SUMO‐protein ligase PIAS; first is predicted interaction, while latter two novel suggest substrate SUMOylation. Using an in vitro SUMOylation assay, we K218 conjugation site on...
April 25, 2018April 10, 2018Free AccessPeripheral Innate Immune Activation Correlates with Disease Severity in GRN Mutation Carriers (P4.178)Peter Ljubenkov, Paige Mumford, Michael McGrath, Isabel Elaine Allen, Zachary Miller, Laura Mitic, Anna Karydas, … Show All , Hilary Heuer, Julio Rojas-Martinez, Ping Wang, Jane Zhang, Adam Staffaroni, Yann Cobigo, Rodney Pearlman, Bruce Howie Rosen, and Boxer FewerAuthors Info & AffiliationsApril 2018 issue90 (15_supplement) Letters to the Editor