A5037307496- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoidosis and Beryllium Toxicity Research
- Medical Imaging and Pathology Studies
- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Eosinophilic Disorders and Syndromes
- Pulmonary Hypertension Research and Treatments
- Respiratory Support and Mechanisms
- Transplantation: Methods and Outcomes
- Vascular Anomalies and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Lung Cancer Treatments and Mutations
- Cardiac tumors and thrombi
- Long-Term Effects of COVID-19
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inflammatory Myopathies and Dermatomyositis
- Neonatal Respiratory Health Research
- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Anesthesia and Sedative Agents
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Atomic and Subatomic Physics Research
- Congenital Diaphragmatic Hernia Studies
- Epilepsy research and treatment
- Pneumonia and Respiratory Infections
Ospedale G.B. Morgagni - L.Pierantoni
2024-2025
University of Padua
2021-2024
Sapienza University of Rome
2018
Endobronchial Ultrasound (EBUS) has emerged as a crucial tool for diagnosing intrathoracic disorders, particularly in the staging of lung cancer. However, its diagnostic capabilities context benign and rare diseases remain subject debate. to investigate yield safety EBUS-transbronchial mediastinal cryobiopsy (EBUS-TMC) comparison needle aspiration (TBNA) broad spectrum diseases. single-centre retrospective observational study conducted on 48 patients who underwent both EBUS-TBNA...
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with limited treatment options. Despite the approval of pirfenidone and nintedanib that slow progression, IPF remains poor survival. Promising therapeutic candidates were tested as potential treatments for while some drugs successful in phase II clinical trials, their transition to positive III was unfortunately disappointing. This highlights “regression truth” concept drug development, whereby trial results may simply be...
Background Few is known about the long-term pulmonary sequelae after COVID-19 infection. Hence, aim of this study to characterize patients with persisting at follow-up hospitalization. We also aimed explore clinical and radiological predictors fibrosis following COVID-19. Methods Two hundred 20 consecutive were evaluated 3–6 months discharge high-resolution computed tomography (HRCT) categorized as recovered (REC) or not (NOT-REC). Both HRCTs hospitalization (HRCT 0 ), when available, HRCT 1...
"Endobronchial Ultrasound-guided Cryobiopsy of Pulmonary Artery Intimal Sarcoma." American Journal Respiratory and Critical Care Medicine, 0(ja), pp.
Since the beginning of SARS-CoV-2 pandemic, over 550 million people have been infected worldwide. Despite these large numbers, long-term pulmonary consequences COVID-19 remain unclear.The aim this single-center observational cohort study was to identify and characterize sequelae at 12 months from hospitalization reveal possible predictors for persistence lung consequences.Based on or absence radiological changes after hospitalization, whole population categorized into NOT-RECOVERED (NOT-REC)...
EBUS-TBNA has represented a revolution in the diagnosis of intrathoracic pathologies, particularly lung cancer staging, replacing more invasive methods such as mediastinoscopy. However, its role diagnosing rare benign or malignant mediastinal disorders is still matter debate. Over past few years, EBUS-guided cryobiopsy been increasingly emerging an innovative and minimally technique these disorders, with excellent safety profile. In this case report, we present young man brought to our...
Sarcoidosis is a multisystemic disease of unknown etiology characterized by the formation granulomas in various organs, especially lung and mediastinal hilar lymph nodes. The clinical course manifestations are unpredictable: spontaneous remission can occur approximately two thirds patients; up to 20% patients have chronic (called Ad-vanced Pulmonary Sarcoidosis) resulting progressive loss function, sometimes life-threatening that lead respiratory failure death. immunopathology mechanism...
Abstract Transbronchial lung cryobiopsy (TBLC) is a relatively new technique for obtaining biopsies, known being the least invasive method while offering high diagnostic yield, favourable safety profile, and significant reduction in morbidity, mortality, hospital stay length compared to surgical biopsy. Radial‐EBUS (r‐EBUS) represent cornerstone modality accessing ‘invisible’ peripheral pulmonary lesions. However, major drawback of these techniques lack ‘real‐time’ visualization biopsy...
Fibrotic hypersensitivity pneumonitis (f-HP) is an interstitial lung disease in which various antigens susceptible individuals may play a pathogenetic role. This study evaluates the role of transbronchial cryobiopsy (TBLC) and bronchoalveolar lavage (BAL) identifying UIP-like pattern its association with fibrosis progression. We conducted multicentre retrospective cohort patients diagnosed f-HP who underwent BAL TBLC between 2011 2023. A was defined by presence (A) patchy fibroblastic foci...
<b>Introduction:</b> EIB is the transient airway narrowing that occurs as a result of exercise. A fall in FEV1 ≥10% after standardized exercise challenge (EC) gold-standard to diagnose EIB. Baseline respiratory symptoms and spirometry poorly relate occurrence <b>Aim:</b> To evaluate whether alternative baseline markers could predict <b>Methods:</b> series functional (IOS, MBNW), inflammatory (FeNO, EBT, cell counts, total specific IgE) patient-reported (AQUA) endpoints were assessed 40...
<b>Introduction:</b> Although BD drugs are the mainstay of therapy to prevent EIB, high variability in individual response treatment has been reported. The presence different endotypes suggested be responsible for such heterogeneity. However, impact endotype on not yet studied EIB. <b>Aim:</b> To assess whether T2-endotype signature could influence <b>Methods:</b> 20 subjects underwent at baseline a standardized exercise challenge (EC) document EIB (FEV1 fall ≥10%) and were divided into two...
Introduction We report a life-threatening case of severe respiratory failure due to pulmonary alveolar proteinosis (PAP) secondary lysinuric protein intolerance (LPI), complicated by pre-existing right pneumothorax, which we treated using rescue whole-lung lavage (WLL). To date, in the literature, there are no cases WLL performed this condition. Clinical condition Patient was referred our center because rapidly worsening dyspnea and deterioration gas exchange, caused form PAP required an...
<b>Background:</b> Sarcoidosis is a chamaleontic disease. While most cases are self-limiting, it important to identify at baseline patients who may require systemic therapy. <b>Aim:</b> potential predictors of need for treatment in with sarcoidosis. <b>Methods:</b> between March 2017 and January 2023, 200 were evaluated our Clinic 142 enrolled. Clinical, radiological, serological values diagnosis retrospectively collected. Patients divided treated (n=91) untreated (n=51). The second-line...
<b>Background.</b> Patients with IIMs can develop ILD during the course of disease, however it is still unclear which patients are at risk for lung involvement. <b>Aim:</b> To identify characteristics IIM involvement and to assess predictors occurrence ILD. <b>Methods:</b> We retrospectively enrolled 253 categorized according presence or absence on CT scan. Clinical laboratory were recorded diagnosis. Univariate multivariate analyses used identifying independent developing pulmonary...