A5072738330- Cellular Mechanics and Interactions
- Microtubule and mitosis dynamics
- Nuclear Structure and Function
- Force Microscopy Techniques and Applications
- Polymer Surface Interaction Studies
- Micro and Nano Robotics
University of Denver
2024-2025
The morphogenesis of developing tissues relies on extensive cellular rearrangements in shape, position, and identity. A key process reshaping is cell intercalation-driven elongation, where epithelial cells align intercalate along a common axis. Typically, analyses focus how peripheral cortical forces influence shape changes. Less attention given to inhomogeneities internal structures, particularly the nucleus, impact shaping. Here, we examine pulsed contractile extension dynamics interact...
In the early Drosophila embryo, germband elongation is driven by oriented cell intercalation through t1 transitions, where vertical (dorsal–ventral aligned) interfaces contract and then resolve into new horizontal (anterior–posterior interfaces. Here, we show that contractile events produce a continuous “rectification” of interfaces, in which systematically rotate toward more orientations. As rotate, their behavior transitions from elongating to regimes, indicating planar polarized...
Filamentous actin has been localized in numerous plant and animal species using various immunocytochemical procedures as well a decoration technique myosin subfragment 1 (SI). In the latter case, long F-actin strands appear herringbones with stacked arrowheads of SI pointing same direction. Unfortunately, when filaments occur shorter oligomers, it may be difficult to discern this pattern against complex background. Using procedures, variabilities labeling patterns encountered attributed use...