A5014115466- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- PI3K/AKT/mTOR signaling in cancer
- CAR-T cell therapy research
- Cytomegalovirus and herpesvirus research
- Polyamine Metabolism and Applications
- Immune responses and vaccinations
- Pharmaceutical Economics and Policy
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Cancer Research and Treatments
- Bioactive Compounds and Antitumor Agents
- Amino Acid Enzymes and Metabolism
- Whipple's Disease and Interleukins
- Cancer Immunotherapy and Biomarkers
Centre International de Recherche en Infectiologie
2021-2025
Inserm
2021-2025
Université Claude Bernard Lyon 1
2021-2025
École Normale Supérieure de Lyon
2017-2025
Centre National de la Recherche Scientifique
2021-2025
Abstract EOMES and T-BET are related T-box transcription factors that control natural killer (NK) cell development. Here we demonstrate regulate largely distinct gene sets during this process. is dominantly expressed in immature NK cells drives early lineage specification by inducing hallmark receptors functions. By contrast, dominant mature cells, where it induces responsiveness to IL-12 represses the cycle, likely through transcriptional repressors. Regardless, many genes with functions...
Abstract Autosomal recessive PRKCD deficiency has previously been associated with the development of systemic lupus erythematosus in human patients, but mechanisms underlying autoimmunity remain poorly understood. We introduced Prkcd G510S mutation that we to a Mendelian cause mouse genome, using CRISPR-Cas9 gene editing. PrkcdG510S/G510S mice recapitulated phenotype and had reduced lifespan. demonstrate this is linked B cell–autonomous role Prkcd. A detailed analysis cell activation shows...
Natural killer (NK) cells often become dysfunctional during tumor progression, but the molecular mechanisms underlying this phenotype remain unclear. To explore phenomenon, we set up mouse lymphoma models activating or not NK cells. Both types elicited type I interferon production, leading to expression of a T cell exhaustion-like signature in cells, which included immune checkpoint proteins (ICPs). However, dysfunction occurred exclusively model that triggered activation. Moreover,...
CD8 T cells and Natural Killer (NK) are cytotoxic lymphocytes important in the response to intracellular pathogens cancer. Their activity depends on integration of a large set environmental cues, including antigenic signal, cytokine stimulation nutrients availability. This is achieved by signaling hubs such as mechanistic target Rapamycin (mTOR). mTOR conserved protein kinase, controlling cellular growth metabolism eukaryotic therefore essential for lymphocyte development maturation....
de niveau recherche, publiés ou non, émanant des établissements d'enseignement et recherche français étrangers, laboratoires publics privés.
> Le virus de la dengue (DENV) est transmis par les moustiques etinduit chez l'hôte infecté des symptômes fébriles et douleurs musculaires qui peuvent évoluer en une fièvre hémorragique.Bien que moitié population mondiale vive dans région