A5070384115- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Inflammation biomarkers and pathways
- Immune Cell Function and Interaction
- Peptidase Inhibition and Analysis
- Alzheimer's disease research and treatments
- Artificial Immune Systems Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Glycosylation and Glycoproteins Research
- Mast cells and histamine
- Kawasaki Disease and Coronary Complications
- Oral microbiology and periodontitis research
- Neonatal and Maternal Infections
- Immunodeficiency and Autoimmune Disorders
- Reproductive System and Pregnancy
- Medicinal Plants and Bioactive Compounds
Jiangsu Hengrui Medicine (China)
2025
Qinghai University
2024
Stomatology Hospital
2018
Capital Medical University
2018
Sichuan University
2016-2018
West China Hospital of Sichuan University
2016
University of Nebraska–Lincoln
1991-1992
Case Western Reserve University
1989
University of California, San Diego
1984
CD40 agonist antibodies are reported to augment tumor antigen presentation and have shown potential anti-tumor efficacy in clinical trials. Nevertheless, the limited on-target, off-tumor toxicity restrict further development of these antibodies. We hypothesize that could be overcome by activating specifically through tumor-specific antigens. Additionally, can improved strategic construction bispecific (bsAbs) refine degree clustering. Therefore, we developed anti-FAPxCD40 bsAbs with varying...
Periodontitis is an infectious disease in which the host immune and inflammatory responses play essential roles resistance to bacterial infection, as well induction of tissue destruction if response dysregulated. The triggering receptor expressed on myeloid cells (TREMs) modulates innate signaling. TREM-1 considered amplifier response, while TREM-2 a negative regulator that has yet be explored periodontal before. We hypothesized TREMs participated during pathogenesis periodontitis....
Induction of IgE class-restricted tolerance was studied in high IgE-responder (BALB/c X SJL)F1 mice, which the parental BALB/c and SJL mice are low respectively. 2,4-Dinitrophenyl (DNP)-specific monoclonal administered to neonatally two forms: soluble at 250 micrograms per injection, or 10-100 ng coupled 25-50 10(6) syngeneic splenocytes by binding chemically reactive hapten trinitrobenzene sulfonate (TNBS) directly conjugated via a heterobifunctional reagent, N-succinimidyl...
Certain aspects of the phenomenon IgE class-restricted tolerance induced in mice by neonatal treatment with monoclonal IgE, either soluble form or coupled to syngeneic spleen cells, were examined. The present studies document that this results from exposure molecules, irrespective their antigen specificity, and resulting effects are polyclonal nature since responses directed against antigenic determinants unrelated tolerance-inducing molecules affected. Moreover, such findings indicate...
Cyclosporin A (CsA) is an undecapeptide fungal metabolite and generally regarded as a new generation of immunosuppressive drugs. We uncovered novel immunomodulatory property CsA potent immunologic stimulator in the murine IgE antibody system. The enhancement responses was observed mice receiving few three daily i.m. injections before Ag priming. Our studies demonstrate points listed below. First, potentiates regardless specificities inbred mice. hierarchy immunopotentiation by follows order...
Abstract Concomitant administration of cyclosporin A (CsA) with Ag has been shown to augment the production Ag-specific IgE in vivo. We demonstrate that addition CsA also markedly potentiated vitro. Low doses (3 and 10 ng/ml) added at time culture initiation selectively enhanced but not IgA or IgG1 production, whereas higher (30 suppressed all isotypes. Augmented was found correlate IL-4 diminished IFN-gamma. Delayed (after 2 days) low Ag-stimulated cultures did potentiate even though...
Among all classes of Ig, IgE exhibits the highest rate fractional catabolism which site and mechanisms is not understood. We construct a panel murine B cell hybridomas to investigate IgE; one these hybridomas, 17A11, constitutively expresses high levels type II FcR (Fc epsilon RII, CD23) (Kd:1.77 nM; max: 1.65 x 10(5], capable clearing receptor-bound IgE. Receptor-mediated endocytosis ligand ensues after binding monomeric DNP-BSA:IgE immune complexes, inhibited by treating 17A11 with...
Objective: To illuminate the temporal expression of triggering receptor expressed on myeloid cells-1 (TREM-1) in experimental periodontitis rat and to investigate function TREM-1 pathogenesis rat. Methods: The model was established maxillary first molar by means 'wire ligation + vaccination periodontal pathogen Porphyromanus gingivalis (Pg) high-sugar diet' Sprague-Dawley (SD) rats. animals were divided into six groups: control group each time points establishing models for one week two five...