A5115959267- Bladder and Urothelial Cancer Treatments
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Hypothalamic control of reproductive hormones
- Reproductive biology and impacts on aquatic species
- Ginkgo biloba and Cashew Applications
- Animal Behavior and Reproduction
- Autophagy in Disease and Therapy
- Polyamine Metabolism and Applications
- Renal cell carcinoma treatment
- Regulation of Appetite and Obesity
- Renal and related cancers
- Nuclear Receptors and Signaling
Central South University
2017-2025
Third Xiangya Hospital
2017-2025
Guangdong Ocean University
2018-2022
Sun Yat-sen University
2013
Sun Yat-sen University Cancer Center
2013
Gemcitabine (GEM) is a first line chemotherapy drug for bladder cancer (BCa). GEM's lack of specificity has led to disadvantages, resulting in low efficiency, especially when combined with the targeted...
Anacardic acid, which is commonly seen in plants of Anacardiaceae, an important composition cashew, ginkgo leaf and fruit, it has been suggested previous research to show antitumor activity. The main aim the present study was evaluate anticancer effects anacardic acid on cell apoptosis prostatic cancer molecular mechanisms this phenomenon. In we found that inhibited proliferation, induced caspase-3/9 activities Bax protein expression cancer. ER stress inducing factors (BiP, CHOP, p-eIF2α),...
It has been suggested that trimethylation of lysine 27 on histone H3 (H3K27me3) is a crucial epigenetic process in tumorigenesis. However, the expression pattern H3K27me3 and its clinicopathological/prognostic significance urothelial carcinoma bladder (UCB) are unclear. In this study, upregulated protein was observed majority UCBs by Western blotting. High examined IHC 59/126 (46.8%) UCB tissues 18/72 (25.0%) normal epithelial (P = 0.002). associated with multifocal tumors lymph node...
Spotted scat (Scatophagus argus) is an economically important mariculture fish worldwide. However, its latent mechanisms of reproductive regulation remain unclear. G protein-coupled receptor 173 (GPR173) the putative phoenixin (Pnx), which together play a role in regulation. little known about function gpr173 S. argus. Herein, two genes argus are identified: gpr173a and gpr173b. Tissue distribution suggested that both gpr173b were highly expressed hypothalamus pituitary gland male female...
<p>Restoration of REDD1 expression counteracts miR-22-mediated Taxol sensitivity. EJ and BIU87 cells were treated with combinations miR-22 mimics, antagonist, shRNA-REDD1, overexpression vector. (A) Protein REDD1, EEF2K, c-caspase 3, c-PARP, LC3-I/II was determined by western blot. (B) CCK-8 used to determine treatment effect on cell proliferation. (C) Flow cytometry detect apoptosis. (D) Autophagy assessed immunofluorescence LCB3 quantification flow cytometry. ***P<0.001,...
<p>miR-22 regulates cell proliferation, apoptosis, and autophagy in EJ BIU87 cells. (A) cells were transfected with miR-22 mimics, inhibitors Protein expression of REDD1, C-caspase 3, c-PARP, LC3-I/II was detected by western blot after intervention on expression. (B) the CCK-8 method used to detect proliferation. (C) Immunofluorescence for marker LC3B quantitated flow cytometry. (D) The effects mimics or apoptosis assessed through annexin V staining cytometry analysis. (E) Cell cycle...
<p>Involvement of REDD1 and miR-22 in Taxol chemosensitivity EJ BIU87 cells. (A-B) The effect knockdown or overexpression on cell proliferation apoptosis was examined BUC CCK-8 used to detect ability, propidium iodide annexin V staining were apoptosis. (C-D) Protein expression c-caspase 3, c-PARP, LC3-I/II, analyzed by western blot following modulation and/or treatment with ***P<0.001, **P<0.01, *P<0.05.</p>
<p>(A-B) The autophagy inhibitors intensified Taxol sensitivity in RT4 cells. Immunofluorescence for the marker LC3B was quantitated with flow cytometry. (C-D) CCK-8 used to determine treatment effect on cell proliferation. (E-F) Restoration of REDD1 expression counteracts miR-22-mediated Taxol-induced inhibition clone formation. T24 cells were treated and combinations miR-22 mimics, or overexpression vector, both. antagonist, shRNA-REDD1, ****P<0.0001, ***P<0.001, **P<0.01,...
<p>Involvement of REDD1 and miR-22 in Taxol chemosensitivity EJ BIU87 cells. (A-B) The effect knockdown or overexpression on cell proliferation apoptosis was examined BUC CCK-8 used to detect ability, propidium iodide annexin V staining were apoptosis. (C-D) Protein expression c-caspase 3, c-PARP, LC3-I/II, analyzed by western blot following modulation and/or treatment with ***P<0.001, **P<0.01, *P<0.05.</p>