A5108047922- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
- Neuroblastoma Research and Treatments
- Kruppel-like factors research
- Neutropenia and Cancer Infections
- Traditional Chinese Medicine Analysis
- Mineralogy and Gemology Studies
- Reproductive System and Pregnancy
- Urinary and Genital Oncology Studies
- Neonatal Health and Biochemistry
- Immune Response and Inflammation
- Nanoplatforms for cancer theranostics
- Macrophage Migration Inhibitory Factor
- Gastric Cancer Management and Outcomes
- Cerebrospinal fluid and hydrocephalus
- GaN-based semiconductor devices and materials
- Lymphatic System and Diseases
- Lung Cancer Research Studies
- Geochemistry and Geologic Mapping
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
Third Xiangya Hospital
2020-2025
Central South University
2020-2025
Changchun University of Chinese Medicine
2025
University of Electronic Science and Technology of China
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Nanjing University
2022
Wuhan University
2022
Renmin Hospital of Wuhan University
2022
Southwest Medical University
2022
Hunan University
2022
Gemcitabine (GEM) is a first line chemotherapy drug for bladder cancer (BCa). GEM's lack of specificity has led to disadvantages, resulting in low efficiency, especially when combined with the targeted...
Abstract Background Circular RNAs (circRNAs) have important functions in many fields of cancer biology. In particular, we previously reported that the oncogenic circRNA, circPRMT5 , has a major role bladder progression. Therapy based on circRNAs good prospects as anticancer strategies. While anti-circRNAs are emerging therapeutics, specific vivo delivery into cells not been and remains challenging. Methods Synthesized chrysotile nanotubes (SCNTs) with relatively uniform length (~ 200 nm)...
In this study, we present a comprehensive comparative analysis of the surge current capability in third quadrant for four commercial 650 V p-GaN gate HEMTs. Temperature-dependent experiments reveal varying degrees negative correlation between and device junction temperature across devices. Gate leakage testing decapsulation failed devices identified two distinct failure modes. Through techniques TCAD simulations, characteristics these modes were thoroughly revealed. For Failure Mode I,...
Solute carrier family 12 member 5 (SLC12A5) has an oncogenic role in bladder urothelial carcinoma. The present study aimed to characterize the molecular mechanisms of SLC12A5 carcinoma pathogenesis. Functional assays identified that interacts with and stabilizes SOX18, then upregulates matrix metalloproteinase 7 (MMP7). In vivo vitro were performed confirm effect SLC12A5's interaction SOX18 on MMP7-mediated progression. was upregulated human tumors, correlated poor survival patients tumor...
There has been an increasing interest in the study of innate immune system recent years. However, few studies have focused on whether immunity can acquire tolerance. Therefore, this study, we investigated tolerance via consecutive weekly and daily injections emulsions modified with polyethylene glycol (PEG), referred to as PEGylated (PE). The effects these PE pharmacokinetics biodistribution were studied normal macrophage-depleted rats. Additionally, evaluated antigenic specificity...
Abstract Background For certain human cancers, sperm associated antigen 5 (SPAG5) exerts important functions for their development and progression. However, whether RNA interference (RNAi) targeting SPAG5 has antitumor effects not been determined clinically. Results The results indicated that Fe-doped chrysotile nanotubes (FeSiNTs) with a relatively uniform outer diameter (15–25 nm) inner (7–8 nm), length of several hundred nanometers, which delivered an siRNA against the oncogene (siSPAG5)...
Cancer Therapy Aptamers have great functions in carrier drug delivery and broad application prospects the field of biomedicine. In article number 2300104, Jianye Liu co-workers report synthesis a novel material, PD-L1-GEMs wherein PD-L1 aptamer gemcitabine, which has targeting ability, are coupled. The facilitate targeted chemotherapy immunotherapy for bladder cancer simultaneously, greatly enhancing efficacy gemcitabine reducing its side effects.
Due to the poor stability and adverse effects of chemotherapy drugs, such as gemcitabine, current effectiveness traditional is minimal. Some patients also show a low response rate immunotherapy. Therefore, novel material PD‐L1‐GEMs designed synthesized with targeted specificity. specifically bind bladder cancer cells. Free gemcitabine cleaved by phosphatase enters cells through macropinocytosis pathway induces cytotoxicity. good stability, binding specificity, significant inhibitory in...
Abstract Due to the poor stability and adverse effects of chemotherapy drugs, such as gemcitabine, current effectiveness traditional is minimal. Some patients also show a low response rate immunotherapy. Therefore, we have designed synthesized novel material PD-L1-GEMs with targeted specificity. specifically bound bladder cancer cells. Free gemcitabine cleaved by phosphatase entered cells through macropinocytosis pathway induced cytotoxicity. showed good stability, binding specificity...
<div>Abstract<p>CD73, originally defined as a lymphocyte differentiation antigen, is thought to function cosignaling molecule on T lymphocytes and an adhesion that required for binding endothelium. We show here CD73 widely expressed many tumor cell lines upregulated in cancerous tissues. Because the ecto-5′-nucleotidase activity of catalyzes AMP breakdown immunosuppressive adenosine, we hypothesized CD73-generated adenosine prevents destruction by inhibiting antitumor immunity....