A5068578448- Nuclear Physics and Applications
- Muon and positron interactions and applications
- Radiopharmaceutical Chemistry and Applications
- Particle accelerators and beam dynamics
- Radiation Therapy and Dosimetry
- Boron Compounds in Chemistry
- Radiation Detection and Scintillator Technologies
- Ion-surface interactions and analysis
- Superconductivity in MgB2 and Alloys
- Advanced materials and composites
- Medical Imaging Techniques and Applications
- X-ray Spectroscopy and Fluorescence Analysis
- Chemical Synthesis and Characterization
- Physics of Superconductivity and Magnetism
- Particle Detector Development and Performance
- Synthesis and properties of polymers
- Antimicrobial Peptides and Activities
- Metal and Thin Film Mechanics
- RNA Interference and Gene Delivery
- Atomic and Molecular Physics
- Accounting and Organizational Management
- NMR spectroscopy and applications
- Silicone and Siloxane Chemistry
- Diamond and Carbon-based Materials Research
- X-ray Diffraction in Crystallography
Horia Hulubei National Institute for R and D in Physics and Nuclear Engineering
2015-2025
National Institutes of Health
2009
National Institute of Research and Development for Optoelectronics
2009
University of Bucharest
2009
National Institute of Materials Physics
2002
The ability to orally administer silver nanoparticles (AgNPs) in enteric capsules implies a direct interaction with the colon microbiota. vitro effect provides portrayal of functional properties under vivo conditions. purpose this study was describe green AgNP synthesis process, using aqueous extract from Lactarius piperatus mushroom, and characterize nanomaterial. We determined its antimicrobial antioxidant effects microbiota healthy individuals via GIS1 system—a transit simulator. Per...
At the Radiopharmaceutical Research Center (CCR) of Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering (IFIN-HH), we operate a TR-19 cyclotron radio isotope production. To broaden our spectrum radioisotopes with applications nuclear medicine, add new external beam line towards state-of-the-art solid target station. Besides practical experience implementation Comecer ALCEO metal targetry system, new, more efficient way tuning onto design dedicated neutron local...
Zirconium-89 (89Zr) is a highly valued diagnostic radionuclide for positron emission tomography (PET) due to its long physical half-life of 78.4 h and decay characteristics, being preferred the radiolabelling nanoparticles slow kinetics macromolecules, such as antibodies. 89Zr-based high-resolution PET images can be employed scan tumours localize tracer on longer timeframe, which allows real-time therapy monitoring. The goal this study was maximize 89Zr production yield by fine-tunning...
To overcome chondrosarcoma's (CHS) high chemo- and radioresistance, we used polyethylene glycol-encapsulated iron oxide nanoparticles (IONPs) for the controlled delivery of chemotherapeutic doxorubicin (IONP
64Cu is a cyclotron-produced radionuclide suitable for positron emission tomography (PET) and internal radiotherapy. We have been focused on radioisotope due to its favorable nuclear characteristics (β+ emission, 18% β− 39%). Moreover, the electron capture (43%) implies Auger with high linear energy transfer in targeted cells. Also, 12.7 hours half-life allows good uptake distribution of radiopharmaceuticals obtain qualitative images contrast. The production no-carrier-added via...
The use of radioisotopes in nuclear medicine applications became essential for the diagnosis and follow-up imaging many oncological, cardiovascular, neurodegenerative diseases, a safe non-invasive way. Their personalized treatment tumors is on verge to change oncological patient management. Optimization production aims maximize efficiency while minimizing side reactions costs. A practical approach balance these non-converging ways employ simulation tools process design phase experimental...
Mitochondria-nucleus communication during stress dictates cellular fate with consequences on the etiopathology of multiple age-related diseases. Impaired mitochondrial quality control through loss function protease HtrA2 associates accumulation damaged mitochondria and triggers integrated response, implicating transcription factor CHOP. Here we have employed a combined model impaired control, namely function, and/or CHOP genotoxicity to address distinctive roles these components in...
The interaction of radiation with matter takes place through energy transfer and is accomplished especially by ionized atoms or molecules. effect on biological systems involves multiple physical, chemical steps. Direct effects result in a large number reactive oxygen species (ROS) within outside inside the cells as well, which are responsible for oxidative stress. Indirect defined alteration normal processes cellular components (DNA, protein, lipids, etc.) caused directly induced radiation....
This article reports the synthesis and characterization of several types organic–inorganic nanocomposites based on epoxy resin/monoglycidylether-terminated poly(dimethylsiloxane) reinforced with 2, 5, or 10 wt% polyhedral oligomeric silsesquioxanes (POSS) bearing one glycidyl (1GE-POSS) eight glycidyl(8GE-POSS) groups. The morphological features studied samples were established through atomic force microscopy, contact angle measurements, X-ray photoelectron spectroscopy, scanning electron...
In 1974, a 9-year-old girl with syringomyelia and scoliosis was treated using the Echols procedure, surgical technique that makes use of metal stent to maintain drainage fluid from syrinx into subarachnoid space. The patient presented authors' institution 34 years later history progressive myelopathy surgically deformities thoracic spine, lumbar right foot. Computer-assisted myelography indicated wire remained in place had collapsed. Neurological examination neurophysiological testing...
A novel apparatus constructed at IFIN‐HH is described for automated synthesis of radiopharmaceuticals labeled with 18F use in positron emission tomography (PET) investigations. [18 F] fluoride was produced the cyclotron by irradiation H2O enriched 97% 18O 13 MeV deuterons, or 8 protons. The irradiated transferred (injected) into radiochemical fully‐automated processing systems which ensured separation from H2O, labeling 18F, and finally purified filtration selective absorbants. system easy...