A5105366415- Cell death mechanisms and regulation
- Mitochondrial Function and Pathology
- Heat shock proteins research
- RNA Interference and Gene Delivery
- Soft Robotics and Applications
- Plant and Fungal Species Descriptions
- RNA and protein synthesis mechanisms
- ATP Synthase and ATPases Research
- Genomics and Phylogenetic Studies
- Natural Compounds in Disease Treatment
- Plant Pathogens and Fungal Diseases
- Antimicrobial Peptides and Activities
- Steroid Chemistry and Biochemistry
- Bioactive Natural Diterpenoids Research
- Microbial Metabolism and Applications
- Research in Cotton Cultivation
- Botulinum Toxin and Related Neurological Disorders
- Stroke Rehabilitation and Recovery
- Immune Response and Inflammation
- Probiotics and Fermented Foods
- CAR-T cell therapy research
- Autophagy in Disease and Therapy
Chinese Academy of Sciences
2005-2025
University of Chinese Academy of Sciences
2025
Shenyang Institute of Automation
2025
Changchun Institute of Applied Chemistry
2024
University of Science and Technology of China
2024
Institute of Zoology
2006-2023
Hunan Normal University
2021
Nankai University
2011
Zhejiang Gongshang University
2009
Cells without Bak and Bax are largely resistant to apoptosis, despite the presence of other key components apoptotic machinery. We screened 7,800 natural compounds found several that could specifically induce caspase activation release cytochrome c (cyto c) in bak(-/-)/bax(-/-) cells. One these was gossypol, a polyphenolic compound naturally cottonseed has been used antifertility trials. but not Bcl-2-interacting molecules, induced cyto loss mitochondrial membrane potential (delta psi m)...
Overwhelming evidence indicates that Bax and Bak are indispensable for mediating cytochrome c release from mitochondria during apoptosis. Here we report a Bax/Bak-independent mechanism of We identified natural diterpenoid compound induced apoptosis in bax/bak double knock-out murine embryonic fibroblasts substantially reduced the tumor growth these cells implanted mice. Treatment with significantly increased expression Bim, which migrated to mitochondria, altering conformation forming...
Stroke-related hand dysfunction significantly limits the ability to perform daily activities. Pneumatic soft gloves can provide rehabilitation training and support for individuals with impaired function, enhancing their independence. This paper presents a novel pneumatic robotic system featuring bidirectional bending actuators. The comprises glove control platform, enabling various gestures assisting finger grasping. main module of actuator features three-stage cavity structure, allowing...
The pH-dependent assembly of Toll-like receptors (TLRs), which triggers a threshold-like response, is key principle in immune signaling. While crystallography has revealed the intricate structure these complexes, mechanisms underlying their pH dependency remain unclear. Herein, constant simulations and metadynamics are employed to investigate stability TLR3/dsRNA signaling complex. findings demonstrate that system regulates complex by modulating protonation charge states histidines....
Fortunella venosa (Rutaceae) is an endangered species endemic to China and its taxonomic status has been controversial. The genus contains a variety of important economic plants with high value in food, medicine, ornamental. However, the placement Genus into Citrus led controversy on taxonomy Systematics. In this present research, Chloroplast genome F. was sequenced using second-generation sequencing, structure phylogenetic relationship analyzed. results showed that size 160,265 bp, typical...
Bcl-2 and Bax share a similar structural fold in solution, yet function oppositely the mitochondrial outer membrane (MOM) during apoptosis. The proapoptotic forms pores MOM to trigger cell death, whereas inhibits pore formation prevent death. Intriguingly both proteins can switch conformation after activation by BH3-only proteins, with multiple regions embedded MOM. Here we tested hypothesis that destabilization of structure might convert Bax-like perforator. We discovered mutations...