A5017837931- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Adhesion, Friction, and Surface Interactions
- Adipokines, Inflammation, and Metabolic Diseases
- Orthopedic Surgery and Rehabilitation
- Bone fractures and treatments
- Muscle and Compartmental Disorders
- Cell Adhesion Molecules Research
- Shoulder and Clavicle Injuries
- Chemokine receptors and signaling
- Elbow and Forearm Trauma Treatment
- Nerve injury and regeneration
- Rheumatoid Arthritis Research and Therapies
- Immune Response and Inflammation
- Shoulder Injury and Treatment
- Heterotopic Ossification and Related Conditions
- Musculoskeletal synovial abnormalities and treatments
- Sports injuries and prevention
- Peripheral Neuropathies and Disorders
- Inflammatory mediators and NSAID effects
- Medical Imaging and Pathology Studies
- Immune cells in cancer
- Signaling Pathways in Disease
Taichung Veterans General Hospital
2013-2024
National Chung Hsing University
2021-2024
Osteoarthritis (OA) is represented by the accumulation and adhesion of M1 macrophages into synovium tissues in joint microenvironment subsequent inflammatory response. Cordycerebroside A, a cerebroside compound isolated from Cordyceps militaris, exhibits anti-inflammatory activity, but has not yet been examined during OA disease. Our results indicate higher expression macrophage markers tissue patients compared with normal healthy controls. Records Gene Expression Omnibus (GEO) data set our...
Osteoarthritis (OA) is a prevalent joint disease commonly associated with aging and obesity, which can lead to pain, stiffness, dysfunction, disability. Omentin-1 (also called intelectin-1) newly discovered adipokine, plays protective role in suppressing the secretion of pro-inflammatory cytokines. Based on data from Gene Expression Omnibus (GEO) dataset clinical samples obtained at our institution revealed, determined that omentin-1 IL-4 (an anti-inflammatory cytokine) levels were...
The concept of osteoarthritis (OA) as a low-grade inflammatory joint disorder has been widely accepted. Many mediators are implicated in the pathogenesis OA. Interleukin (IL)-18 is pleiotropic cytokine with versatile cellular functions that pathogenetically important immune responses, well autoimmune, inflammatory, and infectious diseases. IL-17, proinflammatory mainly secreted by Th17 cells, upregulated OA patients. However, role IL-17 progression unclear. synovial tissues collected from...
The aim of our study was to investigate failure rates reconstruction plate and non-reconstruction plate, find the best strategy for implant selection different fracture types midshaft clavicular fractures. Two hundred twenty-six consecutive patients with fractures who received open reduction fixation during Jan 2012 July 2017 were reviewed. correlations between risk factors including demographic data, classifications, analyzed. AO/OTA classification are most important affecting...
Background: Due to the rapid spread of coronavirus disease-19 (COVID-19), most patients expressed a reluctance undergo postoperative rehabilitation at clinic. Therefore, in this scenario it was necessary reshape crucial role these patients. We conducted telerehabilitation program based on an artificial intelligence brace (AI brace) which can monitor progress through app and internet server. Our hypothesis that home-based might provide clinical outcomes comparable face-to-face, hospital-based...
PurposeThe purpose of this study was to evaluate the effectiveness Marrow stimulation (MS) versus biphasic scaffold loaded with autologous cartilage (Scaffold) in treating focal osteochondral lesions knee.Methods54 patients symptomatic chondral or lesion knee were randomized either Scaffold group MS group. International Knee Documentation Committee (IKDC) subjective score, Injury Osteoarthritis Outcome Score (KOOS), and Magnetic Resonance Imaging (MRI) assessed preoperatively, at one two...
The progression of osteoarthritis (OA) is mediated by adipokines, one which nesfatin-1, responsible for the production inflammatory cytokines. However, how this molecule may affect synthesis proinflammatory cytokine interleukin 1 beta (IL-1β) in OA unclear. Our analyses records from Gene Expression Omnibus (GEO) dataset and clinical specimens synovial tissue revealed higher levels nesfatin-1 IL-1β samples compared with normal healthy tissue. We found that facilitates human fibroblasts...
Abstract Background Multiple approaches for fixation of distal radius fractures exist; nonetheless, there is no consensus on the optimal treatment these injuries. Although using volar locking plates has become increasingly common as a surgical intervention, usefulness bone augmentation remains debatable. Therefore, this study aimed to evaluate necessity fixed with plate. Methods This retrospective enrolled patients single fracture treated plate between January 2014 and December 2016....
Background: Arthroscopic anterior cruciate ligament (ACL) reconstruction with advanced reinforcement system (LARS) had revealed good results low complication and failure rate in series of studies. The specific candidates for ACL LARS are still unknown anyway. purpose this study is to evaluate the activity-related outcome using ligament. Methods: A total 43 unilateral arthroscopic reconstructions were collected divided into two groups: group (preinjury Tegner score ≥ 6, n = 20) B < 23). We...