A5079913415- Lymphoma Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- CAR-T cell therapy research
- Cancer-related Molecular Pathways
- RNA Interference and Gene Delivery
- Chronic Myeloid Leukemia Treatments
- Hedgehog Signaling Pathway Studies
- Ubiquitin and proteasome pathways
- Galectins and Cancer Biology
- Chronic Lymphocytic Leukemia Research
- Nanoparticle-Based Drug Delivery
- Adenosine and Purinergic Signaling
- Acute Myeloid Leukemia Research
- Cell death mechanisms and regulation
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Acute Lymphoblastic Leukemia research
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Autophagy in Disease and Therapy
Singapore General Hospital
2024
The University of Texas Health Science Center at Houston
2015
Brown Foundation
2015
The University of Texas MD Anderson Cancer Center
2009-2011
Patients with advanced stages of mantle cell lymphoma (MCL) have a poor prognosis after standard therapies. MCL cells in those patients often spread into tissues other than lymph nodes, such as the bone marrow. Apart from directed migration and homing, there is little understanding function CXCR4/SDF-1 signaling axis MCL. In this report, we aim to understand mechanisms survival marrow.For comprehensive analyses interactions marrow stromal cells, generated gene knockout using CRISPR-CAS9...
The interaction of immune checkpoint inhibitors (ICI) and concomitant medications such as antibiotics, metformin, statins, beta-blockers, proton pump (PPIs), nonsteroidal anti-inflammatory drugs (NSAIDs), low-dose aspirin has been studied in other malignancies. Our study aims to investigate the relationship between these ICI efficacy patients with advanced hepatocellular carcinoma (aHCC).
<div>Abstract<p><b>Purpose:</b> Patients with advanced stages of mantle cell lymphoma (MCL) have a poor prognosis after standard therapies. MCL cells in those patients often spread into tissues other than lymph nodes, such as the bone marrow. Apart from directed migration and homing, there is little understanding function CXCR4/SDF-1 signaling axis MCL. In this report, we aim to understand mechanisms survival marrow.</p><p><b>Experimental...
<p>Table S1. Jeko, SP53 and Z138 MCL cells (5x103) were cultured in PHA-LCM methylcellulose medium, the numbers of colonies counted a week later. SDF-1 (200 ng/ml) or AMD3100 (40 mM) with added during culture. Table S2. medium human bone marrow stromal cells, HS27a, neutralizing antibodies (100 mg/ml). In some experiments, also using for 24 hours collected colony forming assays. S3. Decreased quiescent PKH-positive cell recovery vivo upon CXCR4 silencing. GFP-positive shRNA control...
<p>Supplemental Figure Legends</p>
<p>Supplemental Table Legends</p>
<p>Figure S1: FACS analyses of CXCR4 silenced in Jeko, SP53 and Z138 MCL cells. GFP-positive cells were sorted after infection expression was evaluated using analyses. 94-74% reduction noted all knock down Figure S2: Migration to SDF-1 effectively decreased silencing. controls or (105) placed upper chambers with different concentrations lower the counted chamber 24 hours. S3: showed migration toward medium harvested from HS27a culture. Medium 3 days 600 mL added transwell. (Jeko, SP53,...
<div>Abstract<p><b>Purpose:</b> Patients with advanced stages of mantle cell lymphoma (MCL) have a poor prognosis after standard therapies. MCL cells in those patients often spread into tissues other than lymph nodes, such as the bone marrow. Apart from directed migration and homing, there is little understanding function CXCR4/SDF-1 signaling axis MCL. In this report, we aim to understand mechanisms survival marrow.</p><p><b>Experimental...
<p>Supplemental Figure Legends</p>
<p>Figure S1: FACS analyses of CXCR4 silenced in Jeko, SP53 and Z138 MCL cells. GFP-positive cells were sorted after infection expression was evaluated using analyses. 94-74% reduction noted all knock down Figure S2: Migration to SDF-1 effectively decreased silencing. controls or (105) placed upper chambers with different concentrations lower the counted chamber 24 hours. S3: showed migration toward medium harvested from HS27a culture. Medium 3 days 600 mL added transwell. (Jeko, SP53,...
<p>Supplemental Table Legends</p>
<p>Table S1. Jeko, SP53 and Z138 MCL cells (5x103) were cultured in PHA-LCM methylcellulose medium, the numbers of colonies counted a week later. SDF-1 (200 ng/ml) or AMD3100 (40 mM) with added during culture. Table S2. medium human bone marrow stromal cells, HS27a, neutralizing antibodies (100 mg/ml). In some experiments, also using for 24 hours collected colony forming assays. S3. Decreased quiescent PKH-positive cell recovery vivo upon CXCR4 silencing. GFP-positive shRNA control...
Abstract Cellular homeostasis requires a delicate balance between proliferation, apoptosis and differentiation be maintained. These processes are regulated by number of tumor suppressors proto-oncogenes that frequently deregulated during progression. Amongst these the TP53/TP63 family sonic hedgehog (SHH) pathway. The SHH network associated with proliferative stem cell niches many organs has been shown to affect disease progression metastasis in diverse cancers. We investigated possibility...