A5041282750- Boron and Carbon Nanomaterials Research
- Energetic Materials and Combustion
- MXene and MAX Phase Materials
- Acute Myeloid Leukemia Research
- Cell death mechanisms and regulation
- 2D Materials and Applications
- RNA Interference and Gene Delivery
- Graphene research and applications
- Metal and Thin Film Mechanics
- Quantum Dots Synthesis And Properties
- Inorganic Chemistry and Materials
- Dental materials and restorations
- Spectroscopy and Chemometric Analyses
- PI3K/AKT/mTOR signaling in cancer
- Chaos-based Image/Signal Encryption
- Metal-Organic Frameworks: Synthesis and Applications
- Remote Sensing in Agriculture
- Covalent Organic Framework Applications
- Service-Oriented Architecture and Web Services
- Nanowire Synthesis and Applications
- Semiconductor Quantum Structures and Devices
- Leaf Properties and Growth Measurement
- Fullerene Chemistry and Applications
- Dental Erosion and Treatment
- Big Data Technologies and Applications
Jilin Agricultural University
2021-2025
Jilin University
2010-2024
State Key Laboratory of Superhard Materials
2020-2024
Chongqing University of Posts and Telecommunications
2021
Jilin Medical University
2018-2020
Heilongjiang University
2020
Wayne State University
2010-2018
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry
2017-2018
National Cancer Institute
2010
Roswell Park Comprehensive Cancer Center
2010
Abstract Acute myeloid leukemia (AML) is a serious disease. The 5-year survival rates remain frustratingly low (65% for children and 26% adults). Resistance to frontline chemotherapy (usually cytarabine) often develops; therefore new treatment modality needed. Bcl-2 family proteins play an important role in balancing cell apoptosis. antiapoptotic have been found be dysregulated AML. ABT-199, BH3 mimetic, was developed target protein Bcl-2. Although ABT-199 has demonstrated promising results,...
Pressure has always been an effective method for uncovering novel phenomena and properties in condensed matter physics. Here, electrical transport study is carried on 2H-TaS2 up to ≈208 GPa, unexpected superconducting state (SC-II) emerging around 86.1 GPa with initial critical temperature (Tc ) of 9.6 K found. As pressure increases, the Tc enhances rapidly reaches a maximum 16.4 at 157.4 which sets new record transition metal dichalcogenides (TMDs). The original (SC-I) found be re-enhanced...
Abstract The antiapoptotic Bcl‐2 family proteins play critical roles in resistance to chemotherapy acute myeloid leukaemia ( AML ). Bcl‐2‐selective inhibitor ABT ‐199 (Venetoclax) shows promising antileukaemic activity against , though Mcl‐1 limits its activity. XPO 1 is a nuclear exporter overexpressed cells and inhibition decreases levels cancer cells. Thus, we hypothesized that the 1‐selective KPT ‐330 (Selinexor) can synergize with induce apoptosis through down‐regulation of Mcl‐1....
As a newly emerging approach for surface-enhanced Raman spectroscopy (SERS), pressure-induced SERS (PI-SERS) has been attracting increasing interest its applications in signal enhancement at extreme conditions. However, how to efficiently realize the PI-SERS and elucidate corresponding mechanism remain open questions. Herein, we demonstrate up 8.04 GPa using monolayer molybdenum disulfide (ML-MoS2) as substrate three organic molecules with similar energy levels but different symmetries...
Synthesis pressure and structural stability are two crucial factors for highly energetic materials, recent investigations have indicated that cerium is an efficient catalyst N2 reduction reactions. Here, we systematically explore Ce–N compounds through first-principles calculations, demonstrating the atom can weaken strength of N≡N bond a rich variety polynitrides be formed under moderate pressure. Significantly, P1̄-CeN6 possesses lowest synthesis 32 GPa among layered metal owing to strong...
By using a modulated synthetic strategy, three isostructural Zr-based metal organic frameworks [Zr6O4(OH)4(EDDC)6] (JLU-Liu34), [Zr6O4(OH)4(EDDC-NO2)6] (JLU-Liu35), and [Zr6O4(OH)4(EDDC-NH2)6] (JLU-Liu36) (H2EDDC = (E)-4,4′-(ethene-1,2-diyl)dibenzoic acid, H2EDDC-NO2 (E)-2,2′-dinitro-4,4′-(ethene-1,2-diyl)dibenzoic H2EDDC-NH2 (E)-2,2′-diamino-4,4′-(ethene-1,2-diyl)dibenzoic acid) which possess different substituent groups have been successfully synthesized. Significantly, the framework...
The high-pressure phase diagram of Co–N compounds is enriched by proposing five stable phases (Pnnm-Co2N, Pmn21-Co2N, Pmna-CoN, Pnnm-CoN2, and P1̅-CoN4) two metastable (P3̅1c-CoN8 P1̅-CoN10). A systematic study has been performed for revealing the novel polymeric nitrogen structure outstanding properties predicted polynitrides, such as structural characterization, energy analysis, stability electronic analysis. P3̅1c-CoN8 with layer-shaped N-structure P1̅-CoN10 band-shaped are first reported...
Two stable high-pressure phases (C2/m-MnN4 and P1̄-MnN4) four metastable (P4/mmm-MnN4, P1̄-MnN5, C2/m-MnN6 P1̄-MnN8) are proposed by using ab initio evolutionary simulations. Besides the reported quasi-diatomic molecule N2, armchair chain S-like chain, N4 ring N22 firstly in P4/mmm-MnN4 P1̄-MnN5 phases. A detailed study is performed on energetic properties, mechanical properties stability of these polynitrogen structures. Ab molecular dynamics simulations show that P1̄-MnN4 can be quenched...
Abstract Acute myeloid leukaemia (AML) is a highly heterogeneous haematologic malignancy with poor prognosis. We previously showed synergistic antileukaemic interaction between exportin 1 (XPO1) inhibitor KPT‐330 (Selinexor) and Bcl‐2 venetoclax (ABT‐199) in preclinical models of AML, which was partially meditated by Mcl‐1, although the full mechanism action remains unknown. In this study, using real‐time RT‐PCR Western blot analysis, we show that inhibition XPO1 via or KPT‐8602 (Eltanexor)...
Two high-pressure stable phases (I41/a-CeN4 and R3̅m-CeN6) two metastable (P6mm-CeN14 P6mm-CeN17) were proposed in Ce–N compounds at 150–300 GPa. The polymeric nitrogen units include quadruple helical chains, N6 rings, first reported layered molecular sieves structures. I41/a-CeN4 can be quenched to ambient conditions its thermal stability maintained up 500 K. P6mm-CeN14 is dynamically mechanically pressure. electronic properties analyses show that charge transfer between the Ce N atoms...
Light and temperature are important environmental factors for maize growth. Appropriate light conditions can enhance the net photosynthetic rate of leaves, which in turn promotes high-quality high-yield production. This study focuses on during seedling stage investigates response patterns leaf rate, relative chlorophyll content (SPAD value), visible–near-infrared spectral data under eight light–temperature stress conditions. Spectrally sensitive bands characteristic wavelengths were...
The hydrogenation of CO2 to methanol over In2O3-based catalysts is highly sensitive the concentration surface oxygen vacancies (Ov). While increasing Ov can enhance catalytic performance, it also increases risk over-reduction during hydrogenation, leading a trade-off between activity and stability. Here, we demonstrate that hierarchical carbon nanocages (hCNCs) act as effective "electron buffering agents" for In2O3, mitigating this thereby enhancing yield, with nitrogen doping hCNCs further...
As the mainstay treatment for advanced prostate cancer, androgen deprivation therapy (ADT) targets action of receptor (AR) by reducing level and/or using anti-androgen to compete with androgens binding AR. Albeit effective in extending survival, ADT is associated dose-limiting toxicity and development castration-resistant cancer (CRPC) after prolonged use. Because CRPC lethal incurable, developing strategies enhance efficacy circumvent resistance becomes an urgent task. Continuous AR...
NaYF4 nanoparticles (NPs) were synthesized by a facile solvothermal approach using polyvinylpyrrolidone (PVP) as surfactant. The NPs doped into P3HT:PCBM blend to fabricate inverted polymer bulk heterojunction (BHJ) solar cells. dependence of device performance on the weight ratio in film was investigated. results showed that open-circuit voltage apparently enhanced doping NPs/PVP composites active layer while maintaining short-circuit current density and fill factor, leading an increase...
Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease in urgent need of newer therapeutic modalities. Majority patients with PDAC have mutations KRAS, which unfortunately remains an ineffectual target. Our strategy here to target KRAS downstream effectors PI3K and mTOR. In this study, we investigated the antitumor efficacy novel mTOR dual inhibitor VS-5584 PDAC. data shows that PI3K/mTOR inhibition causes ERK activation all tested cell lines. Although MEK GSK1120212 could abrogate...
Polynitrogen has been widely studied recently as a rising star of high energy density materials. Here, we performed systematic study the Zr-N compounds in N-rich region by first-principles method. The high-pressure phase diagram system is enriched proposing five new compounds. ZrN
Polymeric nitrogen, as a potential high-energy-density material (HEDM), has many applications, such in energy storage systems, explosives and propellants. Nowadays it is very urgent to find suitable method stabilize polymeric nitrogen at ambient conditions. Herein, we present new hybrid structure where sheets are sandwiched between graphene the form of three-dimensional crystal. According ab initio molecular dynamics (AIMD) calculations phonon spectrum calculations, demonstrated that stable...