A5100397951- Catalytic C–H Functionalization Methods
- Cyclopropane Reaction Mechanisms
- Sulfur-Based Synthesis Techniques
- Synthesis and Reactivity of Heterocycles
- Catalytic Alkyne Reactions
- Radical Photochemical Reactions
- Spectroscopy and Chemometric Analyses
- Oxidative Organic Chemistry Reactions
- Metal-Organic Frameworks: Synthesis and Applications
- Catalytic Cross-Coupling Reactions
- Synthesis and Characterization of Pyrroles
- Zeolite Catalysis and Synthesis
- Synthesis and Catalytic Reactions
- Mesoporous Materials and Catalysis
- Advanced Chemical Sensor Technologies
- Chemical Synthesis and Reactions
- Organometallic Complex Synthesis and Catalysis
- Nanomaterials for catalytic reactions
- Spectroscopy Techniques in Biomedical and Chemical Research
- Chemical Synthesis and Analysis
- Chemical Synthesis and Characterization
- Advanced biosensing and bioanalysis techniques
- Multicomponent Synthesis of Heterocycles
- Seed and Plant Biochemistry
- Organophosphorus compounds synthesis
Guangdong Pharmaceutical University
2018-2025
Southwest University
2018-2025
Jilin University
2020-2025
Jilin Agricultural University
2025
Zhongshan Hospital
2018-2024
University of Hong Kong
2022-2024
China Special Equipment Inspection and Research Institute
2021-2024
Jiangsu University of Science and Technology
2020-2024
Shanghai Changzheng Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Abstract With the maximum atom‐utilization efficiency, single atom catalysts (SACs) have attracted great research interest in catalysis science recently. To address following key challenges for further development of SACs: i) how to stabilize and avoid aggregation SACs, ii) enhance specific surface area conductivity supports, iii) achieve scalable mass production with low cost, a SAC consisting Pd atoms anchored on well‐designed graphdiyne/graphene (GDY/G) heterostructure (Pd 1 /GDY/G) is...
The long-term storage of rice will inevitably be involved in the deterioration edible quality, and aged poses a great threat to food safety human health. acid value can employed as sensitive index for determination quality freshness. In this study, near-infrared spectra three kinds (Chinese Daohuaxiang, southern japonica rice, late rice) mixed with different proportions were collected. partial least squares regression (PLSR) model preprocessing was constructed identify adulteration....
A robust and regioselective palladium-catalyzed intermolecular aerobic oxidative cyclization of 2-ethynylanilines with isocyanides to the synthesis 4-halo-2-aminoquinolines is reported herein. The procedure constructs various moderate excellent yields (47–94%) broad substrates scope. Furthermore, this process can be easily extended 6H-indolo[2,3-b]quinolines via an intramolecular Buchwald–Hartwig cross-coupling reaction in two-step one-pot manner.
Under copper-catalyzed or base-promoted conditions, a wide range of ene-yne-ketones react with H-phosphonates to afford various phosphorylated furans in good yields. A copper carbene generation Michael addition is proposed as the key step selective construction Csp3–P Csp2–P bond, which supported by capture reactions and interval 31P NMR experiments. Furthermore, this method features inexpensive metal catalysts, no usage oxidant, high atom economy, make it attractive practical.
A novel strategy for the synthesis of sulfonylated lactones via Ag-catalyzed radical addition/cyclization reaction 1,6-enynes and sodium sulfinates has been developed. The presents high stereoselectivity under mild conditions with C4 prochiral center construction in one step. ESR experiments relevant mechanistic studies indicated that a pathway should be involved this transformation.
A range of internal alkynes smoothly underwent palladium-catalyzed oxidative annulations with acrylic acid and amide to afford α-pyrones pyridones in good excellent yields high regioselectivity. The usage O2 (1 atm) as a stoichiometric oxidant H2O the only byproduct under mild conditions makes this process more attractive practical.
Calcium carbide was used as the acetylide source to synthesize substituted pyrazoles <italic>via</italic> [3 + 2] cycloaddition/[1,5] sigmatropic rearrangements.
A novel approach for the synthesis of indolizines from 2-(pyridin-2-yl)acetates, ynals, and alcohols or thiols has been developed. This MCR (multicomponent reaction) that proceeds under solvent- metal-free conditions provided a straightforward path to construct indolizines. Furthermore, this reaction demonstrates other attractive features such as widely available starting materials, mild conditions, good functional group tolerance, high efficiency.
An efficient electrochemical system for the construction of diselenytlated indolizines from available pyridines, ketones and diselenides under undivided electrolytic conditions was developed. No external oxidants transition-metal catalysts are needed achieving this three-component tandem reaction realizing C-C, C-N C-Se bond formations.
N-Tosylhydrazones generated in situ from cyclic ketones smoothly underwent a [3 + 2] cycloaddition to afford saturated spirocyclic pyrazoles and further transformed the fused analogues via ring expansion certain cases. An inexpensive renewable resource, calcium carbide, was utilized as carbon source expansion. The salient features of this reaction include widely available starting materials, convenient one-pot/two-step procedure, great efficiency, high regioselectivity. Remarkably,...
A copper-catalyzed cyanothiolation of <italic>N</italic>-tosylhydrazones with thiocyanates to generate α-arylthioalkanenitriles bearing sulfur-substituted quaternary carbon center atoms has been achieved.
A metal-free system for regioselective dehydrogenative cross-couplings between indolizines and oxoaldehydes catalyzed by visible light under mild conditions has been described. As an atom economical eco-friendly protocol, the reaction proceeds in good yields using inexpensive, readily available visible-light sources environmentally friendly oxidant oxygen. Various valuable 1,2-dicarbonyl derivatives attached to indolizine core were easily accessed direct dicarbonylation of sp2 C–H bond.
A wide range of indolizines with allenes proceeded smoothly under mechanochemically induced conditions via a [3+2] annulation process, affording various substituted pyrrolo[2,1,5-cd]indolizines in good yields. The reaction efficiency was greatly improved by using piezoelectric material as the charge transfer catalyst. photophysical properties resulting pyrrolo[2,1,5-cd]indolizine were characterized.
The first attempt at utilizing N-tosylhydrazones as two-carbon synthons has been successfully achieved, which underwent a copper-mediated [3 + 2] oxidative cyclization reaction to afford 2,3,5-trisubstituted furans in moderate good yields. features of this method include inexpensive metal catalyst, readily available substrates, high regioselectivity, and convenient operation. studies provide important approaches for further exploration the powerful diverse abilities N-tosylhydrazones.
A range of indolizine smoothly underwent visible-light-induced intermolecular [3+2] annulations with internal alkynes to afford pyrrolo[2,1,5-cd]indolizine in good excellent yields high regioselectivity. Through this cascade reaction, a series fluoroactive fused indolizines large π-system were conveniently synthesized. The usage visible light as energy source air stoichiometric oxidant under simple conditions makes process attractive and practical.
We have developed a transition-metal free trifluoromethylation protocol between enamines and CF3SO2Na. A wide range of β-trifluoromethyl substituted were delivered in moderate to high yields with only E-configurations.
A novel protocol for the synthesis of α-aryl nitriles has been successfully achieved via a copper-catalyzed cyanation N-tosylhydrazones employing thiocyanate as source cyanide. The features this method include convenient operation, readily available substrates, low-toxicity salts, and broad substrate scope.
A facile transition-metal-free regioselective halogenation of imidazo[1,2-a]pyridines using sodium chlorite/bromite as the halogen source is presented. The reaction has provided an efficient method for formation C-Cl or C-Br bonds to synthesize 3-chloro 3-bromo-imidazo[1,2-a]pyridines which were then efficiently transformed into imidazo[1,2-a]pyridine core π-systems by Suzuki-Miyaura reactions.