A5068111419- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Escherichia coli research studies
- Immunotherapy and Immune Responses
- Gut microbiota and health
- Neuroinflammation and Neurodegeneration Mechanisms
- Reproductive System and Pregnancy
- RNA Research and Splicing
- Bacteriophages and microbial interactions
- Birth, Development, and Health
- Immune Response and Inflammation
- IL-33, ST2, and ILC Pathways
- Cancer-related molecular mechanisms research
- Diabetes and associated disorders
- Celiac Disease Research and Management
- Cancer Research and Treatments
- Reproductive Biology and Fertility
- Adrenal Hormones and Disorders
- Bacterial Genetics and Biotechnology
- Circadian rhythm and melatonin
- Immune cells in cancer
- CAR-T cell therapy research
- RNA modifications and cancer
- Stress Responses and Cortisol
- RNA and protein synthesis mechanisms
Weizmann Institute of Science
2022-2023
Rockefeller University
2023
Hebrew University of Jerusalem
2020-2021
Agricultural Research Organization
2020-2021
The bacteriophage lambda cIII gene product regulates the lysogenic pathway by stabilizing cII regulatory protein. Our results show that expression of is subject to specific requirements. Tests a set cIII-lacZ and operon fusions reveal sequence upstream ribosome binding site needed for translation. contains an inefficient RNase III processing site. Furthermore, drastically reduced in cells lacking III. We have isolated phage carrying mutation (r1), which lies sequence, leads reduction...
Intestinal epithelial cells have the capacity to upregulate MHCII molecules in response certain epithelial-adhesive microbes, such as segmented filamentous bacteria (SFB). However, mechanism regulating expression well impact of MHCII-mediated antigen presentation on T cell responses targeting those microbes remains elusive. Here, we identify cellular network that regulates intestinal epithelium SFB. Since is dispensable for SFB-induced Th17 response, explored other CD4+ cell-based induced by...
Early life heat stress leads to either resilience or vulnerability a similar later in life. We have previously shown that this tuning of the response depends on neural network organization preoptic anterior hypothalamus (PO/AH) thermal center and is regulated by epigenetic mechanisms. Here, we expand our understanding establishment describing role for epitranscriptomic regulation machinery. Specifically, explore N6-methyladenosine (m6A) RNA methylation long-term stress. Heat conditioning...
A stressor can induce resilience in another, different stressor, a phenomenon known as cross-tolerance. To learn if cross-tolerance is governed by epigenetic regulation, we used embryonic heat conditioning (EHC) chicks, during the development of hypothalamus, to increase immunization response. Indeed, EHC induced lifelong systemic antibody response immunization, addition reduced hypothalamic IL6 inflammatory expression following LPS challenge. Since outcome was long-term with immune system,...
Abstract Thymic epithelial cells (TEC) play an indispensable role in the development and selection of immunocompetent, yet self-tolerant T cells. To provide further insights into TEC functional developmental diversity, we utilized multiome analysis, which revealed a detailed atlas compartment based on their transcriptional states chromatin landscapes. The analysis also highlighted numerous unconventional subsets, shared striking similarities with functionally well-defined parenchymal...
Summary The expression of MHCII by intestinal epithelial cells (IEC) determines the severity immunopathological reactions. However, function on IEC under homeostatic conditions remains elusive. Here we report that IECs is a hallmark an adaptive wave immune responses to commensal segmented filamentous bacteria (SFB). Focusing SFB-driven responses, describe pattern and associated antigen processing machinery among subpopulations along with cellular network regulates induction. Furthermore,...
Abstract Stressful environmental events in early life have long‐lasting consequences on later stress responses. We previously showed that heat conditioning of 3‐day‐old chicks during the critical period heat‐response development leads to vulnerability life. Here we assessed role early‐life inflammatory response chick anterior hypothalamus (AH), focusing hypothalamic microglia. identified microglial cell population AH using anti‐KUL01 and anti‐CD45 antibodies. Specific features were also...