A5032822699- Aortic Thrombus and Embolism
- Aortic aneurysm repair treatments
- Cardiac tumors and thrombi
- Kidney Stones and Urolithiasis Treatments
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Dermatological and Skeletal Disorders
- Trace Elements in Health
- Biomedical Research and Pathophysiology
- Gout, Hyperuricemia, Uric Acid
- Heme Oxygenase-1 and Carbon Monoxide
- Lipoproteins and Cardiovascular Health
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Sirtuins and Resveratrol in Medicine
- SARS-CoV-2 and COVID-19 Research
- IL-33, ST2, and ILC Pathways
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Phagocytosis and Immune Regulation
- Atherosclerosis and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
- Inflammasome and immune disorders
- Acute Kidney Injury Research
- Blood disorders and treatments
Nantong University
2022-2025
Ludwig-Maximilians-Universität München
2017-2024
LMU Klinikum
2017-2023
Lanzhou Veterinary Research Institute
2015-2016
Chinese Academy of Agricultural Sciences
2016
Primary/secondary hyperoxalurias involve nephrocalcinosis-related chronic kidney disease (CKD) leading to end-stage disease. Mechanistically, intrarenal calcium oxalate crystal deposition is thought elicit inflammation, tubular injury and atrophy, involving the NLRP3 inflammasome. Here, we found that mice deficient in ASC adaptor protein failed develop nephrocalcinosis, compromising conclusions on CKD. In contrast, hyperoxaluric wild-type developed profound nephrocalcinosis. inhibition using...
Serum oxalate levels suddenly increase with certain dietary exposures or ethylene glycol poisoning and are a well known cause of AKI. Established contributors to crystal-induced renal necroinflammation include the NACHT, LRR PYD domains-containing protein-3 (NLRP3) inflammasome mixed lineage kinase domain-like (MLKL) protein-dependent tubule necroptosis. These studies examined role novel form necrosis triggered by altered mitochondrial function.To better understand molecular pathophysiology...
Cholesterol crystal embolism can be a life-threatening complication of advanced atherosclerosis. Pathophysiology and molecular targets for treatment are largely unknown.We aimed to develop new animal model cholesterol dissect the mechanisms (CC)-driven arterial occlusion, tissue infarction, organ failure.C57BL/6J mice were injected with CC into left kidney artery. Primary end point was glomerular filtration rate (GFR). caused clots occluding intrarenal arteries dose-dependent drop in GFR,...
Cholesterol crystal embolism (CCE) implies immunothrombosis, tissue necrosis, and organ failure but no specific treatments are available. As CCE involves complement activation, we speculated that inhibitors of the C5a/C5aR axis would be sufficient to attenuate consequences like with systemic vasculitis. microcrystal injection into kidney artery wildtype mice initiated intra-kidney immunothrombosis within a few hours followed by sudden drop glomerular filtration rate ischemic necrosis after...
Nicotinamide adenine dinucleotide (NAD+) is a central and pleiotropic metabolite involved in cellular energy metabolism, cell signaling, DNA repair, protein modifications. Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Metabolic stress aging directly affect cardiovascular system. Compelling data suggest that NAD + levels decrease with age, obesity, hypertension, which all notable risk factors for CVD. In addition, therapeutic elevation reduces chronic low-grade...
IL-22, a member of the IL-10 cytokine family, accelerates tubule regeneration upon acute kidney injury, hence we speculated on protective role also in chronic disease. We quantified intrarenal IL-22 expression after unilateral ureteral (UUO) wild-type mice and performed UUO knock-out animals. Obstruction phenotypic differences between IL22+/+ IL22−/− were assessed by histology, immunohistochemistry, immunofluorescence as well western blotting reverse-transcriptase quantitative PCR ex vivo....
Post-ischemic acute kidney injury and disease (AKI/AKD) involve tubular necrosis irreversible nephron loss. Mononuclear phagocytes including conventional dendritic cells (cDCs) are present during different phases of repair, but the functional contribution this subset remains controversial. Transcription factor interferon regulatory 8 (IRF8) is required for development type I (cDC1s) lineage helps to define distinct cDC1 subsets. We identified one among mononuclear phagocyte subsets according...
ABSTRACT Background Cholesterol crystal (CC) embolism causes acute kidney injury (AKI) and ischaemic cortical necrosis associated with high mortality. We speculated that sustaining the fibrinolytic system Glu-plasminogen (Glu-Plg) could be a safe way to attenuate AKI prevent infarction upon CC embolism. Methods induced by injecting into left artery of C57BL/6J mice. The primary endpoint was glomerular filtration rate (GFR). Results Starting as early 2 h after embolism, thrombotic angiopathy...
Cholesterol crystal (CC) embolism can cause acute tissue infarction and ischemic necrosis via triggering diffuse thrombotic angiopathy occluding arterioles arteries. Neutrophils contribute to crystal-induced immunothrombosis as well necrosis-related necroinflammation. We speculated that CC embolism-induced kidney injury (AKI) would be circadian rhythm-dependent associated with cyclic differences in neutrophil function. Injection of into the left induced progressing starting early 3 h after...
Cellular prion protein (PrPC) represents a potential regulator of cellular immunity and has been confirmed to be an invasive receptor exploited by bacteria such as Brucella abortus facilitate the infection in host cells. Up now, there are few informations about role PrPC virus replication Porcine reproductive respiratory syndrome (PRRSV), single positive-stranded RNA virus, prefers infect African green monkey kidney cell line MA-104 its derivatives, Marc-145. We found that is expressed on...
prediction improves to a maximum accuracy of 85% and 90% with 2 microRNA 3 combinations, respectively.
Abstract Background and Aims Cholesterol crystal embolism (CCE) is usually a consequence of the rupture atheromatous plaques in patients with advanced atherosclerosis. We hypothesized that necroinflammation contributes to CCE-related kidney injury/disease (AKI/AKD). Method Injection cholesterol (CC) into C56BL/6 WT mice via left artery induced vascular obstruction, infarction, GFR loss (measured by transcutaneous monitoring sinistrin clearance awake unrestricted mice). recovered baseline at...
Medizinische Klinik und Poliklinik IV, AG Klinische Biochemie, Klinikum der Universität München, Munchen, Germany.