A5011734294- Cancer Immunotherapy and Biomarkers
- Inflammasome and immune disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Endoplasmic Reticulum Stress and Disease
- Cancer Research and Treatments
- Immune Cell Function and Interaction
- Nanoplatforms for cancer theranostics
- Adenosine and Purinergic Signaling
Weifang Chinese Medicine Hospital
2024
Hudson Institute of Medical Research
2016-2021
Tianjin University of Traditional Chinese Medicine
2021
Hudson Institute
2021
Monash Institute of Medical Research
2014
Abstract Metabolic alteration influences cancer immunity. However, the role and mechanism of metabolic adaption on immune checkpoint blockade (ICB) responses remains ill-defined. Here, to identify metabolites that modulate ICB sensitivity, metabolomic profiling in mouse tumor models patients treated with was performed. We identified metabolite inosine associated sensitivity mice humans, overcame resistance several models. Notably, sensitized cells T cell-mediated cytotoxicity by amplifying...