A5050855668- Multiple Myeloma Research and Treatments
- Advanced Radiotherapy Techniques
- Cancer Treatment and Pharmacology
- Lymphoma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Cancer, Lipids, and Metabolism
- Lipoproteins and Cardiovascular Health
- Hematological disorders and diagnostics
- Meat and Animal Product Quality
- HER2/EGFR in Cancer Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Multiple and Secondary Primary Cancers
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Malaria Research and Control
- Protein Degradation and Inhibitors
- Peripheral Neuropathies and Disorders
- Biosensors and Analytical Detection
- Medical Imaging and Analysis
- CRISPR and Genetic Engineering
- Cancer Genomics and Diagnostics
- 3D Printing in Biomedical Research
- Monoclonal and Polyclonal Antibodies Research
- Venomous Animal Envenomation and Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
National University of Singapore
2023-2025
Medisch Spectrum Twente
2003-2024
Netherlands Comprehensive Cancer Organisation
1995-1999
Leiden University
1995
Cultivated meats are typically hybrids of animal cells and plant proteins, but their high production costs limit scalability. This study explores a cost-effective alternative by hypothesizing that controlling the Maillard lipid thermal degradation reactions in pure can create meaty aroma could be extracted from minimal cell quantities. Using spontaneously immortalized porcine myoblasts fibroblasts adapted to suspension culture with 1 % serum concentration, we developed method isolate flavor...
The purpose of this study was to address the question whether patients with bilateral breast cancer (BBC) have a worse prognosis in terms recurrence and survival than primarily unilateral (UBC) following breast-conserving treatment (BCT). From 1983 2000, total 1760 BCT were registered Radiotherapy Department Medisch Spectrum Twente. We defined synchronous BBC as diagnosed both breasts at same time or within period 3 months diagnosis first tumor. One thousand seven hundred sixty performed on...
•Five-year DLBCL survivors have a higher risk of subsequent solid and hematological malignancies than the general population.•Largest excess risks were observed for lung gastrointestinal tract cancer.•Receipt >4500 mg/m2 cyclophosphamide (versus ≤2250 mg/m2) is associated with 1.5-fold increased malignancy risk.•Risk may be lower treated in rituximab era, emphasizing need studies longer follow-up. BackgroundThe introduction significantly improved prognosis diffuse large B-cell lymphoma...
Patients with monoclonal gammopathies comprise a heterogenous group. The few studies on incidence and follow‐up are single‐centre‐based may reflect referral bias. To avoid this, all patients ( n = 1275) in mid‐western Netherlands newly discovered paraproteinaemia 1991, 1992 1993 were included population‐based registry divided into four major diagnostic groups: multiple myeloma plasmacytoma 230, 18%), other haematological diseases 141, 11%), paraprotein‐related internal 191, 15%) gammopathy...
Meat cuts, when cooked and masticated, separate into fibrous structures because of the long-range mechanical anisotropy (LMA) exhibited by muscle fascicles, which is not fully recapitulated in alternative proteins produced using molecular alignment technology like high moisture extrusion. We have developed a scalable perforated micro-imprinting to greatly enhance LMA meat analogue (HMMA). By imprinting 1 mm thick HMMA sheets with patterns (optimized AI), we observed up 5 × more anisotropic...
Diagnostic systems for monoclonal gammopathies use bone marrow and X-ray examinations to exclude multiple myeloma (MM). Data from a population-based registry of unselected patients with paraproteinemia indicate that these tests are often done only when MM is suspected. We used 441 randomly selected develop simple four point “Myeloma Risk Score” based on two readily available laboratory tests. One was given paraprotein concentration ≥10 g/l, one IgG IgA, points IgD light chains only. A score...
3rd ESTRO Forum 2015 S137 T2; and N stage was: 25 Nx, 65 N0, 26 N1, 1 N3.Mastectomy was performed in 17 wide local excision 100.Axillary dissection done 67 sentinel node 33 with a median number of 13 (1-24) lymph nodes excised.52 received chemotherapy 72 endocrine therapy.All radiotherapy (1 neo-and 116 adjuvant) breast/chest wall alone 40 regional nodal irradiation.The time to onset LE from the completion 0.5 y (0.1 7.8).LEs included: 38 truncal and/or breast pain; 24 arm lymphedema; 16...
Image-guided radiotherapy of lung cancer patients revealed systematic anatomical changes that eventually result in decreased target coverage and increased doses to organs at risk (OARs)1. Since online adaptive may improve the treatment quality, primary aim this study was report on our initial experience with for stage III a simulation setting. Five (T3-4, N0-1), who were clinically treated using fractionation scheme 20*3, 24*2.75 or 30*2 Gy, retrospectively included. For each patient, 9 12...