A5036531349- Supramolecular Self-Assembly in Materials
- Celiac Disease Research and Management
- Conducting polymers and applications
- Food Allergy and Anaphylaxis Research
- Proteins in Food Systems
- Agriculture Sustainability and Environmental Impact
- Bacteriophages and microbial interactions
- Protein Hydrolysis and Bioactive Peptides
- Silk-based biomaterials and applications
- Enzyme Structure and Function
- Neurobiology and Insect Physiology Research
- Electrochemical sensors and biosensors
- Advanced Sensor and Energy Harvesting Materials
- Protein Structure and Dynamics
- Microscopic Colitis
- Enzyme Production and Characterization
- 3D Printing in Biomedical Research
- Microbial Inactivation Methods
- Meat and Animal Product Quality
- Antimicrobial Peptides and Activities
- Biotin and Related Studies
- Lipid Membrane Structure and Behavior
- Enzyme Catalysis and Immobilization
- Alzheimer's disease research and treatments
- Animal Genetics and Reproduction
Massey University
2020-2025
Riddet Institute
2020-2025
University of Auckland
2015-2025
University of Canterbury
2009-2025
MacDiarmid Institute for Advanced Materials and Nanotechnology
2011-2025
University of Michigan
2022-2023
Advisory Board Company (United States)
2022
Duke University
2022
Harvard University
2022
Stanford University
2022
Piezoelectric organic polymers are promising alternatives to their inorganic counterparts due mechanical flexibility, making them suitable for flexible and wearable piezoelectric devices. Biological such as proteins have been reported possess piezoelectricity, while offering additional benefits, biocompatibility biodegradability. However, questions remain regarding protein the impact of secondary structure. This study examines properties lysozyme amyloid fibril films, plasticized by...
Cultivated meats are typically hybrids of animal cells and plant proteins, but their high production costs limit scalability. This study explores a cost-effective alternative by hypothesizing that controlling the Maillard lipid thermal degradation reactions in pure can create meaty aroma could be extracted from minimal cell quantities. Using spontaneously immortalized porcine myoblasts fibroblasts adapted to suspension culture with 1 % serum concentration, we developed method isolate flavor...
Plastic waste is ubiquitously spread across the world and its smaller analogs—microplastics nanoplastics—raise particular health concerns. While biological impacts of microplastics nanoplastics have been actively studied, chemical bases for adverse effects are sought after. This work explores contributory factors by combining results from in vitro model mammalian membrane experimentation to assess outcome cell/nanoplastic interactions molecular detail, inspecting individual contribution...
Protein nanofibrils offer advantages over other nanostructures due to the ease in their self-assembly and versatility of surface chemistry available. Yet, an efficient general methodology for post-assembly functionalization remains a significant challenge. We introduce generic approach, based on biotinylation thiolation, multi-functionalization protein self-assembled from whey proteins. Biochemical characterization shows effects onto nanofibrils' surface, giving insights into changes...
Amyloid fibrils are a class of insoluble protein nanofibers that formed via the self-assembly wide range peptides and proteins. They increasingly exploited for broad applications in bionanotechnology, such as biosensing drug delivery, nanowires, hydrogels, thin films. have been prepared from many proteins, but there has no definitive characterization amyloid hemoglobin to date. Here, nanofiber formation was carried out under denaturing conditions using solutions apo-hemoglobin extracted...
The use of mammalian muscles as device actuators is severely limited by their sensitivity to environmental conditions and short lifetime. To overcome these limitations insect muscle stem cells were used generate organized 3D constructs with significant enhancements in tolerance long term function. These tissues self-assembled, self-repaired, survived for months culture without media replenishment produced stresses up 2 kPa, all under ambient conditions. continued function days even...
Amyloid fibrils have been recognized as having potential in a variety of bionanotechnological applications. However, realization these applications is constrained by lack control over morphology and alignment, both crucial for end uses. This article focuses on the use growth storage conditions to length amyloid formed from bovine insulin, with distributions constructed transmission electron microscopy (TEM) images. Growth temperature, pH, protein concentration, were examined seen offer range...
The ability of proteins to form hierarchical structures through self-assembly provides an opportunity synthesize and organize nanoparticles. Ordered nanoparticle assemblies are a subject widespread interest due the potential harness their emergent functions. In this work, toroidal-shaped protein peroxiredoxin, which has pore size 7 nm, was used iron oxyhydroxide Iron in Fe2+ sequestered into central cavity toroid ring using metal-binding sites engineered there then hydrolyzed particles bound...
The self-assembling and gelation properties of a bioactive peptide derived from bovine casein (FFVAPFPEVFGK) were studied in the peptide's natural form (uncapped, uncapFFV) capped with protecting groups added to both termini (capped, capFFV). Although (uncapFFV) did not demonstrate self-assembly, (capFFV) spontaneously self-assembled formed self-supporting gel. Variations concentration incubation time influenced gel's mechanical properties, suggesting could be tuned exploited for different...
Summary Food‐derived peptides are promising materials for oral delivery purposes as they readily available, can be generated using common techniques, and their self‐assembly properties tuned specific applications. A method identifying such self‐assembling bioactive (SABP) candidates based on in silico analysis was developed allowed the discovery of a bovine‐derived SABP: FFVAPFPEVFGK. This peptide then successfully from α s1 ‐casein enzymatic hydrolysis isolated with size exclusion...
Protein nanofibers are emerging as useful biological nanomaterials for a number of applications, but to realize these applications requires cheap and readily available source fibril-forming protein material. We have identified fish lens crystallins feedstock the production report optimized methods their production. Altering conditions formation leads individual assembling into much larger structures. The ability control morphology form higher order structures is crucial step in bottom up...
Protein nanofibrils and nanotubes are now widely accepted as having potential for use in the field of bionanotechnology. For this to be a feasible alternative existing technologies, there is need commercially viable source. Previous work has identified amyloid fibrils formed from crude crystallin proteins such source, since these can produced large quantities at low cost. Applications include templates formation nanowires or biosensing scaffolds. There remains number practical...
Recent research has highlighted the exciting possibilities enabled by use of protein structures as nanocomponents to form functional nanodevices. To this end, control over protein–protein and protein–surface interactions is essential. In study, authors probe interaction human peroxiredoxin 3 with gold surfaces, a that been previously identified having potential in nanotechnology. Analytical ultracentrifugation transmission electron microscopy revealed pH mediated assembly toroids into...
3,6,7-trimethyllumazine (Lepteridine™) is a newly discovered natural pteridine derivative unique to Mānuka (Leptospermum scoparium) nectar and honey, with no previously reported biological activity. Pteridine derivative-based medicines, such as methotrexate, are used treat auto-immune inflammatory diseases, honey reportedly possesses anti-inflammatory properties topically wound dressing. MMP-9 potential candidate protein target it upregulated in recalcitrant wounds intestinal inflammation....