A5021565232- Retinal Diseases and Treatments
- Optical Coherence Tomography Applications
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Advanced Fluorescence Microscopy Techniques
- Photoacoustic and Ultrasonic Imaging
- 3D Printing in Biomedical Research
- Corneal surgery and disorders
- Ocular and Laser Science Research
- Corneal Surgery and Treatments
- bioluminescence and chemiluminescence research
- Cardiovascular Disease and Adiposity
- Dermatology and Skin Diseases
- Ocular Surface and Contact Lens
- Advancements in Transdermal Drug Delivery
- Retinal Development and Disorders
- Retinal and Optic Conditions
- Microfluidic and Bio-sensing Technologies
Sun Yat-sen University
2022-2025
Zhongshan Hospital
2024
Abstract Meibomian gland dysfunction (MGD) is a leading cause of evaporative dry eye disease, presenting challenge for targeted treatment. Traditional topical ocular drug delivery methods often fail to effectively reach the meibomian glands (MGs). To address this, study has developed soluble microneedles (MN) patch comprising poly(vinyl alcohol), cyclodextrin modified polyacrylic acid, and new indocyanine green. This innovative MN facilitates transdermal release peroxisome...
Speckle noise is the main cause for quality degradation of Optical Coherence Tomography (OCT) images. However, speckle reduction challenging due to complex statistically modelling and requirement a large amount annotated data conventional supervised learning strategies. In this paper, novel semi-supervised method proposed in OCT images with limited labeled data. Our creates pseudo labels co-teaching training process between U-shaped Convolutional Neural Network Transformer shifted window...
In this study, a dual-mode full-field optical coherence tomography (FFOCT) was customized for label-free static and dynamic imaging of corneal tissues, including donor grafts pathological specimens. Static images effectively depict relatively stable structures such as stroma, scar, nerve fibers, while highlight cells with active intracellular metabolism, specifically epithelial cells. The complementarily demonstrate the 3D microstructural features cornea limbus. Dual-modal reveals...
To explore the functional and morphological variations of retinal vessels in diabetes with no clinically detectable retinopathy (NDR) mild non-proliferative diabetic (NPDR) to establish a high-performance NPDR diagnostic model. Normal subjects type 2 patients NDR were recruited. Oxygen-saturation-related parameter (optical density ratio ODR) characteristics (fractal dimension Df, vessel area rate VAR, mean vascular diameter Dm, tortuosity τ) different areas extracted single fundus...
Purpose: To develop a computational method for oxygen-saturation-related functional parameter analysis of retinal vessels based on traditional color fundus photography, and to explore their characteristic alterations in type 2 diabetes mellitus (DM). Methods: 50 DM patients with no-clinically detectable retinopathy (NDR) healthy subjects were enrolled the study. An optical density ratio (ODR) extraction algorithm separation oxygen-sensitive oxygen-insensitive channels photography was...
The structural and functional imaging of ophthalmic tissues in cellular level play an important role the understanding evaluation physiology pathology diseases. In this study, we developed a dual-mode full-field optical coherence tomography (FFOCT) that is capable acquiring label-free images freshly excised tissues, achieving static contrasts gained from refractive index gradients dynamic contrast induced by endogenous cell motility related to functions. Through experiments on both normal...