A5042573839- Cystic Fibrosis Research Advances
- Sirtuins and Resveratrol in Medicine
- Natural product bioactivities and synthesis
- Phytochemical compounds biological activities
- Legume Nitrogen Fixing Symbiosis
- Synthesis and biological activity
- Plant biochemistry and biosynthesis
- Advanced biosensing and bioanalysis techniques
- Synthesis and Characterization of Pyrroles
University of Genoa
2023-2024
Institute for Macromolecular Studies
2019
While plant polyphenols possess a variety of biological properties, exploration chemical diversity around them is still problematic. Here, an example application the Ugi multicomponent reaction to combinatorial assembly artificial, yet “natural-like”, presented. The synthesized compounds represent second-generation library directed inhibition β-amyloid protein aggregation. Chiral enantiopure compounds, and polyphenol-β-lactam hybrids have been prepared too. biochemical assays highlighted...
The search and development of effective sirtuin small molecule inhibitors (SIRTIs) continues to draw great attention due their wide range pharmacological applications. Based on SIRTs’ involvement in different biological pathways, ligands were investigated for many diseases, such as cancer, neurodegenerative disorders, diabetes, cardiovascular diseases autoimmune diseases. elucidation a substantial number SIRT2–ligand complexes is steering the identification novel more selective modulators....
Cystic fibrosis (CF), the most common autosomal recessive fatal genetic disease in Caucasian population, is caused by mutations gene encoding cystic transmembrane conductance regulator (CFTR), an anion channel that regulates salt and water transport across a variety of secretory epithelia. Deletion phenylalanine at position 508, F508del, CF-causing mutation, destabilises CFTR protein, causing folding trafficking defects lead to dramatic reduction its functional expression. Small molecules...