A5103106991- Cancer Research and Treatments
- Virus-based gene therapy research
- bioluminescence and chemiluminescence research
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Ultrasound in Clinical Applications
- Cancer Immunotherapy and Biomarkers
- Trauma and Emergency Care Studies
- Viral Infections and Immunology Research
- Hemodynamic Monitoring and Therapy
- Liver physiology and pathology
- Advanced MRI Techniques and Applications
- Prenatal Screening and Diagnostics
- Emergency and Acute Care Studies
- Radiology practices and education
- Radiation Dose and Imaging
- Viral gastroenteritis research and epidemiology
- Microtubule and mitosis dynamics
- Bone and Joint Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Pelvic and Acetabular Injuries
- Airway Management and Intubation Techniques
- Reconstructive Facial Surgery Techniques
- Telemedicine and Telehealth Implementation
- Facial Nerve Paralysis Treatment and Research
McMaster University
2016-2024
Mayo Clinic in Florida
2022-2023
Neurological Surgery
2022-2023
St. Luke's University Health Network
2023
Schwartz/Reisman Emergency Medicine Institute
2023
Ottawa Hospital
2023
3M (United States)
2023
University of Toronto
2023
Impact
2023
Queen's University
2023
Summary the data using a maximum‐likelihood method was that 66.4 yo of triploids were result dispermy, 23.6 % fertilization haploid ovum by diploid sperm formed failure first meiotic division in male and 10 egg maternal division. The possible sources error inherent technique me reviewed our results compared with previously published data. This work supported grant from Spencer Foundation, no. 6–47 National Foundation HD 07879 Institutes Health. We are extremely grateful to Miss Shirley Yee...
Abstract The genetic transfer of antigen receptors is a powerful approach to rapidly generate tumor-specific T lymphocytes. Unlike the physiologic T-cell receptor, chimeric (CARs) encompass immunoglobulin variable regions or receptor ligands as their recognition moiety, thus permitting cells recognize tumor antigens in absence human leukocyte expression. CARs encompassing CD3ζ chain activating domain induce proliferation vitro, but limited survival. requirements for genetically targeted...
<h3>Background:</h3> Ground-level falls are common among older adults and the most frequent cause of traumatic intracranial bleeding. The aim this study was to derive a clinical decision rule that safely excludes clinically important bleeding in who present emergency department after fall, without need for computed tomography (CT) scan head. <h3>Methods:</h3> This prospective cohort 11 departments Canada United States enrolled patients aged 65 years or presented falling from standing on...
The hepatocyte growth factor (HGF)/Met signalling pathway is up-regulated in many cancers, with downstream mediators playing a role DNA double strand break repair. Previous studies have shown increased radiosensitization of tumours through modulation Met by genetic methods. We investigated the effects anti-HGF monoclonal antibody, AMG102, on response to ionizing radiation model glioblastoma multiforme vitro and vivo. Radiosensitivity was evaluated U-87 MG human glioma cell line. activation...
Abstract Purpose: Low–molecular weight (LMW) chemotherapeutics are believed to reach tumors through diffusion across capillary beds as well membrane transporters. Unexpectedly, the delivery of these agents seems be augmented by reductions in tumor interstitial fluid pressure, an effect typically associated with high–molecular molecules that principally convection. We investigated hypothesis improved intratumoral convection can alter metabolism and enhance a LMW chemotherapeutic agent solid...
Objective The objective of this study is to identify the top five influential papers published on renal point-of-care ultrasound (POCUS) and biliary POCUS in adult patients. Methods A 14-member expert panel was recruited from Canadian Association Emergency Physicians (CAEP) Ultrasound Committee Fellowship Collaborative. All members have had fellowship training or equivalent, are actively engaged scholarship, involved with at their local site nationally Canada. We used a modified Delphi...
The present study compared cultural differences in the UK and China relation to Applied Behaviour Analysis (ABA)-based interventions for children with autism. In UK, seven participants were interviewed (five professionals two parents of autism). China, eight took part interviews three parents). Marked policy found delivery ABA-based early autism e.g., home vs. school programmes.
Abstract The successful translation of gene therapy for clinical application will require the assessment transgene activity as a measure biological function therapeutic transgene. Although current imaging permits noninvasive detection expression, critical need quantitative action expressed has not been met. In vivo magnetic resonance spectroscopic (MRSI) was applied to quantitatively delineate both concentration and cytosine deaminase–uracil phosphoribosyltransferase (CD-UPRT) fusion enzyme...
Bone precursor cells (BPCs) play a critical role in bone maintenance and regeneration. Currently, no tool exists to study BPCs or other marrow cell types directly within their complex microenvironment. Here, we describe vivo magnetic resonance imaging (MRI) of anatomical structures inside the medullary cavity mouse femur. We demonstrate that passively labeled with iron oxide-containing particles can be monitored by MRI intact at an in-plane resolution 43x25 microm. Anatomical detail provided...
Objective The objective of this study is to identify the top five most influential papers published on focused assessment with sonography in trauma (FAST) and extended FAST (E-FAST) adult patients. Methods An expert panel was recruited from Canadian Association Emergency Physicians (CAEP) Ultrasound Committee Fellowship Collaborative. These experts are ultrasound fellowship-trained or equivalent, involved point-of-care (POCUS) research scholarship, leaders both POCUS program at their local...
Aneurysmal bone cysts are benign osseous lesions containing blood-filled cavities separated by walls of connective tissue. They can be difficult to identify clinically due similarities in presentation, imaging, and histology with other pathologies. Specifically, it is important distinguish these from malignant processes, as both surgical medical management differ. We present the case a 21-year-old patient who presented impaired motor sensory function his lower extremities. Radiologic...
Abstract Objective Physicians vary in their computed tomography (CT) scan usage. It remains unclear how physician gender relates to clinical practice or patient outcomes. The aim of this study was assess the association between and decision order head CT scans for older emergency patients who had fallen. Methods This a secondary analysis prospective observational cohort conducted 11 hospital departments (EDs) Canada United States. primary enrolled were 65 years presented ED after fall....
BACKGROUND: Free muscle transfer for dynamic smile reanimation in facial paralysis is associated with excessive cheek bulk, asymmetric excursion vector, and nasolabial folds. In addition, bilateral reconstruction challenging. Postoperative ICU admission common, hospital stays typically between 5 7 days. Prolonged operative times, longer stays, time to animation are free flap options. Lengthening temporalis myoplasty (LTM) provides one-stage equivalent results tissue fewer secondary...
Supplementary Figure 1 from Imaging Transgene Activity <i>In vivo</i>
Supplementary Figure 4 from Imaging Transgene Activity <i>In vivo</i>