A5101177840- Ion channel regulation and function
- Neuroscience of respiration and sleep
- Neuroscience and Neuropharmacology Research
- Adenosine and Purinergic Signaling
- Astrophysics and Star Formation Studies
- Wnt/β-catenin signaling in development and cancer
- Stellar, planetary, and galactic studies
- Astronomy and Astrophysical Research
- Cancer-related gene regulation
- Nicotinic Acetylcholine Receptors Study
- Pain Mechanisms and Treatments
- Rock Mechanics and Modeling
- Chemical Synthesis and Analysis
- Coal Properties and Utilization
- Sleep and Wakefulness Research
- Retinal Diseases and Treatments
- Tryptophan and brain disorders
- Neuroscience and Neural Engineering
- Nitric Oxide and Endothelin Effects
- Cancer-related Molecular Pathways
- Connective tissue disorders research
- Astrophysical Phenomena and Observations
- Zebrafish Biomedical Research Applications
- Neuroendocrine regulation and behavior
- Pharmacological Receptor Mechanisms and Effects
Imperial College London
2004-2024
Henan Polytechnic University
2024
Xi'an Jiaotong University
2011
Institute of Cancer Research
2002-2007
University College London
2000-2003
MSD (UK) Limited (United Kingdom)
2001
Hybrigenics (France)
2001
Vollum Institute
2001
Oregon Health & Science University
2001
UCL Australia
2000-2001
Acid-sensing ion channels (ASICs) are members of the epithelial sodium channel (ENaC)-degenerin family two-pass transmembrane segment protein subunits which form multimeric cation channels. Members ENaC-degenerin gated by stimuli as diverse protons, peptides and mechanical distension. Here we describe a new member family, SPASIC or ASIC 4 (spinal cord ASIC) is expressed throughout central nervous system in an overlapping population neurons that also express subunit MDEG2. ASIC-4 shows 44%...
Graphical Abstract figure legend HCN channels play an evolutionarily conserved pacemaker role in renal pelvic smooth muscle (RPSM) of lower and higher order mammals. The function hyperpolarization-activated cation (HCN) pacemakers remains controversial. Renal trigger contractions that expel waste from the kidney, have been localized to these tissues. To date, however, mechanisms underlying RPSM activity remain elusive. was investigated both (top left) (bottom mammalian models, which exhibit...
Peripheral pain thresholds are regulated by the actions of inflammatory mediators. Some act through G-protein-coupled receptors on voltage-gated sodium channels. We have found that a low-threshold, persistent tetrodotoxin-resistant Na+ current, attributed to NaV1.9, is upregulated GTP and its non-hydrolysable analogue GTP-gamma-S, but not GDP. Inclusion GTP-gamma-S (500 microM) in internal solution led an increase maximal current amplitude > 300 % within 5 min. In clamp, upregulation was...
Dishevelled family proteins are multidomain intracellular transducers of Wnt signals. Ectopically expressed mammalian 2 (Dvl-2) activates downstream signalling and localises to cytoplasmic puncta. It has been suggested that these Dvl-2-containing structures correspond vesicles may be involved in the signal transduction process. We report puncta primarily formed cells expressing Dvl-2 at high levels. Lower levels expression can activate without forming The do not localise with markers early...
Abstract The main aim of this investigation was to determine whether a functional relationship existed between epidermal growth factor (EGF) and voltage‐gated sodium channel (VGSC) upregulation, both associated with strongly metastatic prostate cancer cells. Incubation EGF for 24 h more than doubled VGSC current density. Similar treatment significantly dose‐dependently enhanced the cells' migration through Transwell filters. Both patch clamp recordings assay suggested that endogenous played...
Electrophysiological studies of dorsal root ganglion (DRG) neurons, and the results PCR, Northern blot in situ hybridization analyses have demonstrated molecular diversity Na+ channels that operate sensory neurons. Several subtypes α-subunit been detected DRG neurons transcripts encoding all three β-subunits are also present. Interestingly, one α subunit, Nav 1.8, is selectively expressed C-fibre Aδ fibre associated predominantly involved damage sensing. Another channel, 1.3, up regulated a...
As a clean energy source and disaster gas, coal gas migrates not only under in-situ conditions, but also stress disturbance due to mining. Although diffusion/desorption is key extraction effects prevention, the influence study of change insufficient. This aims investigate mechanism action diffusion, transport model considering developed. Firstly, diffusivity anthracite different conditions was measured using an experimental platform coal-rock diffusivity. When loaded for sample reduces 95%,...
ABSTRACT Herschel surveys have found large numbers of sources with red far-IR colours, and spectral energy distributions (SEDs) rising from 250 to 500 µm: risers. The nature role these is not fully understood. We here present Submillimeter Array (SMA) interferometric imaging at 200 GHz a complete sample five risers F500 >44 mJy selected within 4.5 deg2 region the XMMLSS field. These observations can resolve separate components multiple allow cross identification other wavelengths...
ABSTRACT High-redshift protoclusters consisting of dusty starbursts are thought to play an important role in galaxy evolution. Their nature makes them bright the far-infrared (FIR)/submm but difficult find optical/near-infrared (NIR) surveys. Radio observations excellent way study these starbursts, as dust is transparent radio and there a tight correlation between FIR emission galaxy. Here, we present MeerKAT 1.28 GHz imaging three Herschel candidate protoclusters, with synthesized beam size...
ABSTRACT Arp 220 is the prototypical ultraluminous infrared Galaxy (ULIRG), and one of brightest objects in extragalactic far-infrared sky. It result a merger between two gas rich spiral galaxies which has triggered starbursting activity nuclear regions. Observations with submillimeter array centred at frequency 345 GHz synthesized beamsize $0.77\times 0.45$ arcsec were used to search for polarized dust emission from regions 220. Polarized was clearly detected 6 $\sigma$ significance...