A5086293308- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Salivary Gland Disorders and Functions
- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Systemic Lupus Erythematosus Research
- Multiple Myeloma Research and Treatments
- Nanowire Synthesis and Applications
- Chemokine receptors and signaling
- Natural product bioactivities and synthesis
- Diabetes and associated disorders
- Advancements in Semiconductor Devices and Circuit Design
- Atherosclerosis and Cardiovascular Diseases
- RNA Interference and Gene Delivery
- Phagocytosis and Immune Regulation
- Adenosine and Purinergic Signaling
- Curcumin's Biomedical Applications
- Monoclonal and Polyclonal Antibodies Research
- Bioactive Compounds and Antitumor Agents
University of Bergen
2019-2024
Bose Institute
2017-2019
Combination of a CAR and chimeric costimulatory receptor augments cytotoxicity durability T cells elimination antigen-low tumors.
Tumour progression is associated with immune-suppressive conditions that facilitate the escape of tumour cells from regimen immune cells, subsequently paralysing host defence mechanisms. Induction CD4(+) CD25(+) FoxP3(+) T regulatory (Treg) has been implicated in mechanism, although novel anti-cancer treatment strategies targeting Treg remain unknown. The focus this study to define interaction between and system, i.e. how tolerance starts gradually leads induction adaptive microenvironment....
Primary Sjögren's syndrome (pSS) is associated with polymorphisms and mRNA expression profiles that are indicative of an exaggerated innate type I IFN immune response. Excessive activation potential signaling pathways may play a role in this profile, but the intracellular profile disease not well characterized. To gain insights into potentially dysfunctional pSS patients we conducted exploratory analysis MAPK/ERK JAK/STAT networks peripheral blood mononuclear cells (PBMC) from 25 female...
Abstract Immunotherapy profoundly impacted cancer treatments by harnessing the patient’s immune system. Phagocytosis, process whereby cells engulf and destroy foreign particles or cells, plays a critical role in tumour cell clearance. Herein, we introduce novel concept termed “ENPHASYS” – En hancement of Pha gocytic Sy napse s designed to direct amplify phagocytosis using heterobifunctional molecules named phagocytic synapse enhancers (PSEs). By engineering de novo PD-L1 binder linked...
Abstract Psoriasis is a chronic, inflammatory skin disease characterized by dysregulated immune response and systemic inflammation. Up to one-third of patients with psoriasis have psoriatic arthritis (PsA). Targeted treatment antibodies neutralizing tumor necrosis factor can ameliorate both diseases. We here explored the impact long-term infliximab on composition activity status circulating cells involved in chronic joint Immune were analyzed multicolor flow cytometry. measured markers...
Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease, characterized by mononuclear cell infiltrates in the salivary and lacrimal glands, leading to glandular atrophy dryness. Patient heterogeneity lack of knowledge regarding its pathogenesis makes pSS difficult disease manage. An exploratory analysis using mass cytometry was conducted MAPK/ERK JAK/STAT signaling pathways peripheral blood cells (PBMC) from 16 female medication free patients (8 anti-Sjögren's syndrome-related...
Current treatment strategies for multiple myeloma (MM) are highly effective, but most patients develop relapsed/refractory disease (RRMM). The anti-CD38/CD3xCD28 trispecific antibody SAR442257 targets CD38 and CD28 on MM cells co-stimulates CD3 T (TCs). We evaluated different key aspects such as avidity interaction, tumor killing, biomarkers drug potency in three distinct cohorts of RRMM patients. found that a significantly higher proportion (86%) exhibited aberrant co-expression compared to...
Psoriasis is a chronic immune-mediated skin disease accompanied by systemic inflammation and comorbidities. We analyzed peripheral blood mononuclear cells (PBMCs) in the search for immune signatures biomarkers related to psoriasis severity treatment effect. Thirty-two patients with 10 matched healthy controls were included. PBMCs collected before after initiation of anti-TNF, anti-IL-17 or anti-IL-12/23 utilizing 26-parameter mass cytometry. The number circulating Th17, Th22, Th9, cytotoxic...