A5079368434- Inflammatory Myopathies and Dermatomyositis
- Systemic Sclerosis and Related Diseases
- Eosinophilic Disorders and Syndromes
- Dermatological and Skeletal Disorders
- Skin and Cellular Biology Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA Research and Splicing
- Parkinson's Disease and Spinal Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nuclear Structure and Function
- Dermatologic Treatments and Research
- Muscle Physiology and Disorders
- Autoimmune Bullous Skin Diseases
- Heterotopic Ossification and Related Conditions
Xiangya Hospital Central South University
2022-2025
Central South University
2022-2025
Objectives Idiopathic inflammatory myopathies (IIMs) are a group of heterogeneous autoimmune diseases. Intron retention (IR) serves as an important post-transcriptional and translational regulatory mechanism. This study aims to identify changes in IR profiles IIM subtypes, investigating their influence on proteins correlations with clinical features. Methods RNA sequencing liquid chromatography-tandem mass spectrometry were performed muscle tissues obtained from 174 patients 19 controls,...
ABSTRACT Aim To investigate the effect of abatacept in hypochlorous acid (HCLO)‐induced fibrosis model and to analyze changes immune cell fractions within abatacept‐treated early diffuse systemic sclerosis (SSc) cohort. Methods Fibrosis was induced BALB/c mice by subcutaneous injection HCLO, injected intraperitoneally on alternate days starting day 28. After 6 weeks, we assessed pathological changes, inflammation, myofibroblast activation, percentage ICOS CD3+ T cells. Potential pathways...
Background: Cytokines play a vital role in the pathogenesis of idiopathic inflammatory myopathies (IIMs). Here, we investigated expression serum cytokine profiles untreated IIMs and their correlations with clinical indicators, further studied related cytokines receptors IIMs. Methods: The Human 48-Plex Luminex assay for was performed IIMs, including 93 18 follow-up (39 samples) patients, 32 healthy controls (HC). Mann-Whitney U test bonferroni adjusted used to identify differentially...
Dermatomyositis (DM) is an infrequent disease subgroup of idiopathic inflammatory myopathies characterized by distinct skin lesions. However, high heterogeneity makes clinical diagnosis and treatment DM very challenging.
Background Cellular and molecular biology, combined with research on the human microbiome metabolome, have provided new insights into pathogenesis of systemic sclerosis (SSc). However, most studies gut microbiota (GM) metabolome in SSc are observational studies. The impact confounding factors reverse causation leads to different insights. To shed light this matter, we utilized Mendelian randomization (MR) determine causal effect GM/metabolites SSc. Methods Based summary-level data from...
Abstract Objectives Identification of characteristics and risk factors new-onset dermatomyositis patients with recurrent aggravation after regular treatment. Methods In this cohort study, clinical 142 were analyzed. We defined three different outcomes long-term follow-up: mild, aggravation, death. The presentation aggravations was primarily analyzed discussed in cohort. decision tree algorithm used to predict the outcomes. Results corhort, there 72 mild group, 56 group (39 single 17 multiple...