A5103016961- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Disorders and Syndromes
- Muscle Physiology and Disorders
- Spondyloarthritis Studies and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Autoimmune and Inflammatory Disorders Research
- Hepatitis C virus research
- Genetic diversity and population structure
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Gout, Hyperuricemia, Uric Acid
- Helicobacter pylori-related gastroenterology studies
- Neuroendocrine Tumor Research Advances
- Cell Adhesion Molecules Research
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Genetic Syndromes and Imprinting
- IgG4-Related and Inflammatory Diseases
- Osteoarthritis Treatment and Mechanisms
- Power Line Inspection Robots
- Dermatologic Treatments and Research
- Cancer, Hypoxia, and Metabolism
- Scoliosis diagnosis and treatment
- Psoriasis: Treatment and Pathogenesis
- E-commerce and Technology Innovations
- Skin and Cellular Biology Research
First Affiliated Hospital of Hebei Medical University
2021-2025
Hebei Medical University
2021-2025
Beijing Jishuitan Hospital
1990-2025
Peking University
1990-2025
Capital Medical University
2023-2025
Harbin Huade University
2024
Central South University
2017-2024
Xiangya Hospital Central South University
2017-2024
Xi'an Honghui Hospital
2024
Xi'an Jiaotong University
2024
Muscle cell necrosis is the most common pathological manifestation of idiopathic inflammatory myopathies. Evidence suggests that glycolysis might participate in it. However, mechanism unclear. This study aimed to determine role muscle damage occurs DM/PM.Mass spectrometry was performed on lesions from DM/PM and control subjects. The expression levels pyruvate kinase isozyme M2 (PKM2), nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3)...
Purpose Previous studies have reported that neutrophil-to-lymphocyte ratio (NLR) at pre-treatment was predictive for overall survival (OS) and pathologic complete response (pCR) in breast cancer (BC) patients receiving neoadjuvant chemotherapy (NAC). This study aims to explore the role of both pre- post-NLR OS as well longitudinal NLR kinetics towards pCR BC undergoing NAC. Methods We retrospectively included 501 who received NAC from 2009 2018. pre-, mid (every two cycles NAC)-,...
Pancreatic cancer is characterized by occult onset, low early diagnosis rate, rapid progress, and poor prognosis. Due to the response rate PD-L1 expression in pancreatic cancer, therapeutic application of PL-L1 inhibitors greatly limited. In vitro studies showed that increased cells stimulated fluorouracil (5-FU). We aim explore combining effect 5-FU anti-PD-L1 antibody, provide a reference for clinical antibody cancer. current study, male BALB/c mice were adopted construct tumor-bearing...
Objective: Many biological or targeted synthetic disease‐modifying anti‐rheumatic drugs (b/ts DMARDs) are used in the treatment of psoriatic arthritis (PsA) during recent years, but there few head‐to‐head studies that directly compare these to evaluate and relative efficacy treatments at week 24. The aim this study is conduct a comprehensive comparison all clinically bDMARDs tsDMARDs for PSA using network meta‐analysis drugs, which evaluated by ACR20, ACR50, ACR70, PASI75, PASI90. Methods:...
Abstract: Gouty arthritis is a common arthritic disease caused by the deposition of monosodium urate crystals in joints and tissues around it. The main pathogenesis gout inflammation crystals. Omics studies help us evaluate global changes during recent years, but most used only single omics approach to illustrate mechanisms gout. In this review, we review genomics, transcriptomics, epigenetics, proteomics, metabolomics gout, observing that different genes, DNA methylation, miRNAs, LncRNAs,...
Dermatomyositis and polymyositis are the best known idiopathic inflammatory myopathies (IIMs). Classic histopathologic findings include infiltration of cells into muscle tissues. Neutrophil serine proteinases (NSPs) granule-associated enzymes play roles in cell migration by increasing permeability vascular endothelial cells. In this study, we aimed to find NSPs pathogenesis IIMs.RNA DNA were isolated measure relative expression their methylation levels. The serum tissues was tested...
Aim: Dermatomyositis (DM) and polymyositis (PM) are refractory systemic autoimmune diseases with unknown pathogenesis. miRNAs is an important epigenetic mechanism to regulate gene expression. Methods: We performed whole analysis, transcription analysis the association between miRNAome mRNAome. Results: For there were common specific mRNAs in muscles of DM PM. Among them, expression levels miR-196a-5p CPM negatively correlated PM, miR-193b-3p NECAP2 Protein carboxypeptidase M (CPM) plays...
Few small sample size studies have reported lymphocyte count was prognostic for survival in small-cell lung cancer (SCLC). This study aimed to validate this finding, build prediction model overall (OS) and whether novel models that combine lymphocyte-related variables can predict OS more accurately than a conventional using clinical factors alone large cohort of limited-stage SCLC patients.This enrolled 544 patients receiving definitive chemo-radiation with pre-radiotherapy including...
DM and PM are characterized by myofibre damage with inflammatory cell infiltration due to the strong expressions of MHC class I HLA-A monocyte chemoattractant protein-1 (MCP-1). Dysferlin (DYSF) is a transmembrane glycoprotein that anchors in sarcolemma myofibres. DYSF mutation closely associated inherited myopathies. This study aimed determine role development DM/PM.
Matrix metalloproteinases 9 (MMP9) is a member of the zinc-ion-dependent proteinases family and plays pathogenic role in chronic inflammatory autoimmune diseases. However, its roles pathogenesis myositis have not been elucidated. In this study, we aimed to determine gene expression serum level MMP9 their relationship with clinical features serological parameters myositis. Our results showed that mRNA peripheral blood mononuclear cells (PBMC) was upregulated patients compared healthy...
In this paper, the damage constitutive model of reactive powder concrete (RPC) in uniaxial tension is investigated. The relationship between tensile strength RPC and steel fiber admixture was analyzed by preparing specimens with different volume admixtures for tests, stress–strain curves were recorded. test results show that significantly enhanced an increase doping, especially after doping amount greater than 2%, showing a linear increase. Based on classical mechanics Weibull distribution,...
To the Editor: Idiopathic inflammatory myopathies (IIMs) are a diverse group of rare and refractory systemic autoimmune diseases. DNA methylation, influenced by both inherited sequences environmental exposure, is critical epigenetic factor that regulates gene expression modifying transcriptional chromatin accessibility regulatory within genes.[1–3] explore potential pathogenic mechanisms identify accessible biomarkers for DM PM, we conducted comprehensive analysis alterations in methylome...
Comparison of the efficacy S8 navigation system-assisted correction versus manual in treatment adolescent congenital scoliosis (ACS).