A5025697771- Cytokine Signaling Pathways and Interactions
- Adrenal Hormones and Disorders
- Hormonal and reproductive studies
- Pituitary Gland Disorders and Treatments
- Thyroid Disorders and Treatments
- Hormonal Regulation and Hypertension
- Drug-Induced Hepatotoxicity and Protection
- Adrenal and Paraganglionic Tumors
- Stress Responses and Cortisol
- Synthesis and Reactions of Organic Compounds
- Monoclonal and Polyclonal Antibodies Research
- Psoriasis: Treatment and Pathogenesis
- Renal function and acid-base balance
- Bioactive Compounds and Antitumor Agents
- Vitamin K Research Studies
- Cancer Immunotherapy and Biomarkers
- Inflammasome and immune disorders
- Electrolyte and hormonal disorders
- Plant-based Medicinal Research
- Nicotinic Acetylcholine Receptors Study
- Pharmacological Receptor Mechanisms and Effects
- Medical and Biological Sciences
- Cancer, Stress, Anesthesia, and Immune Response
- Drug-Induced Ocular Toxicity
- Acne and Rosacea Treatments and Effects
Compugen (Israel)
2023-2024
Mount Sinai Hospital
1941-2008
Mount Sinai Hospital
1950-1964
Columbia College
1952
Royal College of Physicians
1952
Columbia University
1952
The Mount
1952
Johns Hopkins Hospital
1932-1935
Johns Hopkins University
1932-1935
Imipramine and desmethylimipramine (DMI) enhance the nictitating membrane contraction in response to 5-HT, NE electrical stimulation of cervical sympathetic nerve. In acute experiment, imipramine potentiates 5-HT more than NE. DMI is most potent compounds studied enhancing Prolonged pretreatment with results preferential sensitization Secondary amines iminodibenzyls, iminostilbenes, dibenzocycloheptadienes -trienes having an n-propyl chain are corresponding tertiary amines. Structurally...
The development of experimental exophthalmos in the guinea pig is dependent on accumulation large quantities intercellular ground substance and water connective tissue orbital contents. This evidenced by presence considerable amounts metachromatic material, which hyaluronic acid an important component, increase hexosamine content these tissues.
IN A previous paper published in 1948 (1) we reported on the effect of ACTH a patient with myasthenia gravis and thymic tumor. This initial study was conducted during early days therapy when hormone available only limited amounts. The treated 40 mg. daily for period four days, treatment followed by an appreciable decrease size mass subsequent improvement myasthenic symptoms. Since this report published, salutary patients without enlargement has been confirmed elsewhere (2). However, Shy his...
Within the past twelve years there has occurred a tremendous increase both in understanding of pathologic physiology and treatment Addison's disease. The study this particular problem received its impetus essentially as result two major contributions, preparation fairly potent adrenal cortex extract<sup>1</sup>and recognition underlying blood electrolyte disturbances which presence destruction cortex.<sup>2</sup> results these investigations showed that was followed by marked excretion...
It was recently reported that ACTH is capable of suppressing the phenomenon local tissue reactivity, when administered intramuscularly 2 hours prior to provocative injection meningococcus culture filtrate (). The experiments embodied in following paper serve extend these observations. Experimental. Substances failing inhibit or modify reactivity bacterial filtrates. interpretation results present studies facilitated by considering failure a variety substances reactivity. In published() and...
Recombinant cytokines have limited anticancer efficacy mostly due to a narrow therapeutic window and systemic adverse effects. IL18 is an inflammasome-induced proinflammatory cytokine, which enhances T- NK-cell activity stimulates IFNγ production. The of naturally blocked by high-affinity endogenous binding protein (IL18BP). IL18BP induced in the tumor microenvironment (TME) response upregulation negative feedback mechanism. In this study, we found that upregulated TME compared with...
Article1 March 1960OSTEOPOROSIS IN CUSHING'S SYNDROMEA. IANNACCONE, M.D., J. L. GABRILOVE, F.A.C.P., S. A. BRAHMS, SOFFER, F.A.C.P.A. M.D.Search for more papers by this author, F.A.C.P.Search authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-3-570 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOsteoporosis is a striking serious feature of Cushing's syndrome. This...
In a previous paper we reported that the parenteral injection of epinephrine into both intact and totally thyroidectomized dog resulted in an increase secretion thyrotropin from adenohypophysis. this was evidenced by development hyperplastic changes thyroid following daily adrenalin-in-oil. Serum obtained similarly treated animals, when injected subcutaneously young guinea pigs not exceeding 200 g weight, thyroids pigs. It further circulating thyrotropic factor resulting dogs reached its...
This study deals with (1) the evaluation of amount circulating thyrotropic factor in clinical hyperthyroidism, (2) effect iodine on such factor, and (3) influence parenteral injection adrenalin discharge from anterior pituitary intact totally thyroidectomized experimental animals. Method. Biological assay was used for determination factor. technic involves histological examination thyroids young guinea pigs not exceeding 200 g weight, following subcutaneous 5 cc serum patient or The were...
The administration of adrenocorticotropin results in a decreased collection I131 by the thyroid gland both intact and adrenalectomized rat, suggesting that inhibits adenohypophyseal secretion thyrotropin.
AKNOWLEDGE of the underlying adrenocortical pathology is practical importance in therapeutic management Cushing's syndrome. There are no clinical signs or symptoms which serve to differentiate syndrome due carcinoma from that adenoma hyperplasia. Differentiation adrenal by means level urinary neutral 17-ketosteroids often impossible, although a very high titer ketosteroids suggestive evidence favor malignant lesion (1). Plasma and 17-hydroxycorticoid assays x-ray examination following...
THE widespread use of long-term therapy with corticotropin (ACTH) in the treatment numerous medical disorders has stimulated search for a potent and long-acting intramuscular repository form. The introduction gelatin (Gel-ACTH) 1952 more recently zinc hydroxide (Zn-ACTH) have made available two such preparations clinical use. sustained effectiveness single dose these been measured past primarily by indirect laboratory tests increased function adrenal cortex responsiveness to therapy. Levin...
The initial hemoconcentration which is observed in suprarenal insufficiency the dog due at least part to a renal loss of extracellular fluid. It followed during early stage repair by further water, primarily intracellular origin, reflection cellular damage not made manifest until this reanal excretion takes place recovery phase. first effect cortical hormone upon animal produce an increased urinary potassium, nitrogen, and phosphates, retention sodium chlorides.
We have described, the metabolism of sodium-d-lactate in normal individuals and patients with acute diffuse parenchymal disease liver. The results obtained suggested possibility use this substance as a test for liver function. It should be emphasized that is quite different from racemic or 1-salt which all previous work has been done. performed before breakfast, consists intravenous injection 75 mg. per kilo body weight 10 to 14% solution sodium-d-lactate. A control sample blood, collected...
THIS study is concerned with the effect of thryrotropin administration on adrenocortical function in hypothyroid and euthyroid subject. As reported previously (1) evidences decreased are encountered not only instances hypothyroidism secondary to adenohypophysial disease but also patients or experimental animals primary thyroidal deficiency. In former group desiccated thyroid may precipitate insufficiency. latter subjects, however, following therapy thyroid, various indices reflect increased...
Synthetic beta1-24 corticotropin has been labeled with I131 and intravenously administered to normal subjects. Analysis of the blood radioactivity following intravenous administration corticotropin-I131 revealed that this substance an apparent space distribution 43% body weight a plasma half-life 7 minutes.
Journal Article ADRENAL CORTICAL RESPONSE OF PROPYLTHIOURACIL TREATED RATS TO THE ADMINISTRATION EPINEPHRINE AND ADRENOCORTICOTROPIN Get access Endocrinology, Volume 47, Issue 6, 1 December 1950, Pages 461–464, https://doi.org/10.1210/endo-47-6-461 Published: 01 1950 history Received: 07 July
Article1 October 1945THE USE OF THIOURACIL IN THE TREATMENT PATIENTS WITH HYPERTHYROIDISMJ. L. GABRILOVE, M.D., M. J. KERT, SOFFER, M.D.J. M.D.Search for more papers by this author, authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-4-537 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHISTORICAL REVIEWThe origin of the use thiouracil in treatment hyperthyroidism stems from...