A5043370670- Cytokine Signaling Pathways and Interactions
- Total Knee Arthroplasty Outcomes
- Systemic Lupus Erythematosus Research
- Inflammasome and immune disorders
- Orthopaedic implants and arthroplasty
- Psoriasis: Treatment and Pathogenesis
- Synthesis and Reactions of Organic Compounds
- Cancer Immunotherapy and Biomarkers
- Temporomandibular Joint Disorders
- Musculoskeletal pain and rehabilitation
- Bioactive Compounds and Antitumor Agents
- Monoclonal and Polyclonal Antibodies Research
- Hip disorders and treatments
- Phytochemical compounds biological activities
- Medical Practices and Rehabilitation
- Laser Applications in Dentistry and Medicine
- Osteoarthritis Treatment and Mechanisms
- Peripheral Neuropathies and Disorders
- Surgical Sutures and Adhesives
- Bone fractures and treatments
- CAR-T cell therapy research
- Electrolyte and hormonal disorders
- MicroRNA in disease regulation
- Shoulder Injury and Treatment
- Orthopedic Infections and Treatments
Compugen (Israel)
2023-2024
Tel Aviv Sourasky Medical Center
1993-2018
Tel Aviv University
2003-2016
Sheba Medical Center
2009-2014
Haifa Medical Center
1986-1988
Recombinant cytokines have limited anticancer efficacy mostly due to a narrow therapeutic window and systemic adverse effects. IL18 is an inflammasome-induced proinflammatory cytokine, which enhances T- NK-cell activity stimulates IFNγ production. The of naturally blocked by high-affinity endogenous binding protein (IL18BP). IL18BP induced in the tumor microenvironment (TME) response upregulation negative feedback mechanism. In this study, we found that upregulated TME compared with...
// Assaf Menachem 1 , Victoria Makovski Or Bodner Metsada Pasmanik-Chor 2 Reuven Stein Noam Shomron 3 Yoel Kloog Department of Neurobiology, Tel Aviv University, 69978 Aviv, Israel Bioinformatics Unit, The George S. Wise Faculty Life Sciences, Cell and Developmental Biology, Sackler Medicine, Correspondence to: Menachem, e-mail: assafmena@gmail.com Kloog, kloog@post.tau.ac.il Keywords: astrocytes, small RNA, lung tumor, intercellular transfer, chemotherapy Received: October 04, 2015...
Anaplastic Thyroid carcinoma is an extremely aggressive solid tumor that resists most treatments and almost always fatal. Galectin-3 (Gal-3) important marker for thyroid carcinomas a scaffold of the K-Ras protein. S-trans, transfarnesylthiosalicylic acid (FTS; Salirasib) Ras inhibitor inhibits active forms proteins. Modified citrus pectin (MCP) water-soluble citrus-fruit-derived polysaccharide fiber specifically Gal-3. The aim this study was to develop novel drug combination designed treat...
Antiphospholipid syndrome (APS) is a multisystem disorder characterized by arterial and venous thrombosis, pregnancy morbidity, neuropsychiatric manifestations. IgG injected intracerebro‐ventricularly (ICV) cause behavioral hyperactivity in mice. In the present study we investigated effects of APS whole‐serum ICV administration female Balb/C Control mice were with serum derived from healthy subjects or saline solution. Behavior was assessed staircase apparatus which combines locomotor...
Antiphospholipid syndrome (APS) is characterized by thromboses and neuropsychiatric manifestations possibly linked to brain inflammation. In order examine the levels of proinflammatory anti-inflammatory cytokines in experimental APS (eAPS) mice brains, we measured TNF- α , IFN- γ IL-10 homogenates (cytosolic fractions) slices (secreted level) at 6, 15, 24 weeks after immunization. We induced eAPS immunization Balb/c with β 2 -glycoprotein I ( GPI), major autoantigen disease controls adjuvant...
Abstract IL-18 is an inflammasome induced proinflammatory cytokine that augments T and NK cell activity stimulates IFNγ production. The of naturally blocked by a high affinity endogenous binding protein (IL-18BP). IL-18BP in the tumor microenvironment (TME) response to upregulation negative feedback mechanism. By evaluating 88 human specimens serum samples we were able show upregulated TME (median 11.2ng/gr) compared 0.3ng/ml). Moreover, showed most bound IL-18BP. IL-18BP-bound levels...
<p>Supplemental Figure S3. Antitumor activity of anti-mouse-IL-18BP Ab in mice studies.</p>
<div>Abstract<p>Recombinant cytokines have limited anticancer efficacy mostly due to a narrow therapeutic window and systemic adverse effects. IL18 is an inflammasome-induced proinflammatory cytokine, which enhances T- NK-cell activity stimulates IFNγ production. The of naturally blocked by high-affinity endogenous binding protein (IL18BP). IL18BP induced in the tumor microenvironment (TME) response upregulation negative feedback mechanism. In this study, we found that...
<p>Supplemental Figure S1. IL-18BP is a potential soluble immune checkpoint in cancer.</p>
<p>Supplemental Figure S4. Anti-IL-18BP Ab induced immunogenic memory response in E0771 tumor model.</p>
<p>Supplemental Figure S5. IL-18BP blockade alters the immune infiltrate composition of E0771 tumors.</p>
<p>Supplemental Figure S1. IL-18BP is a potential soluble immune checkpoint in cancer.</p>
<p>Supplemental Figure S3. Antitumor activity of anti-mouse-IL-18BP Ab in mice studies.</p>
<p>Supplemental Figure S4. Anti-IL-18BP Ab induced immunogenic memory response in E0771 tumor model.</p>
<p>Supplemental Figure S2. COM503 releases IL-18 activity in biochemical and functional assays.</p>
<div>Abstract<p>Recombinant cytokines have limited anticancer efficacy mostly due to a narrow therapeutic window and systemic adverse effects. IL18 is an inflammasome-induced proinflammatory cytokine, which enhances T- NK-cell activity stimulates IFNγ production. The of naturally blocked by high-affinity endogenous binding protein (IL18BP). IL18BP induced in the tumor microenvironment (TME) response upregulation negative feedback mechanism. In this study, we found that...
<p>Supplemental Figure S5. IL-18BP blockade alters the immune infiltrate composition of E0771 tumors.</p>
<p>Supplemental Figure S2. COM503 releases IL-18 activity in biochemical and functional assays.</p>