A5024473946- Advanced Synthetic Organic Chemistry
- Asymmetric Hydrogenation and Catalysis
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Chemical synthesis and alkaloids
- Catalytic C–H Functionalization Methods
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Marine Sponges and Natural Products
BGI Research
2024
BGI Group (China)
2024
Institut de Chimie Moléculaire et des Matériaux d'Orsay
2023
Université Paris-Saclay
2023
Centre National de la Recherche Scientifique
2023
Xiamen University
2015-2019
Collaborative Innovation Center of Chemistry for Energy Materials
2018
Exosomal biomarker detection holds great importance in the field of vitro diagnostics, offering a non-invasive and highly sensitive approach for early disease personalized treatment. Here, we proposed an “APPROACH” strategy, combining aptamer-mediated proximity ligation assay (PLA) with rolling circle amplification (RCA) time-resolved Förster resonance energy transfer (TR-FRET) semi-homogenous exosomal biomarkers. PLA probes consisted cholesterol-conjugated oligonucleotide, which anchored to...
A new strategy to construct allylamines through reductive alkenylation of secondary amides with enamines is reported. The method features the use trifluoromethanesulfonic anhydride as an activation reagent amides, and unconventional reagents. In this manner, serve surrogates alkene carbanions instead classical enolates equivalents. possible mechanism involving a Hoffmann-like elimination amine-borane complex intermediate proposed.
Based on the Tf 2 O‐mediated intermolecular reaction of secondary amides with enamines derived from ketones, a novel approach to β‐enaminones has been developed. The is widely functional group tolerant and highly chemoselective. In presence 4 Å molecular sieves, method can be extended one‐pot condensation ketones for NH synthesis.
Abstract A direct transformation of secondary amides into α‐branched ketones with enamines as soft alkylation reagents was developed. In this reaction, serve surrogates alkyl carbanions, rather than the conventional enolates equivalents in Stork's reactions, which allowed for easy introduction groups electrophilic functional groups. presence 4 Å molecular sieves, method can be extended to one‐pot coupling aldehydes yield ketones. magnified image
Abstract A new protocol for the deacylation of secondary amides and isolation amines is reported based on activation with Tf 2 O, followed by addition organocerium reagents, acidic work‐up.
Abstract An original synthetic strategy is presented for the preparation of sensitive 3‐amino‐4‐hydroxypyrrolidinone‐4‐acetic acid residue that present in structures microsclerodermin natural product family. The approach relies on use a linear γ‐amino surrogate, derived from asparagine, bearing β‐dithiolanyl group. A protected dipeptide model system used to demonstrate selective removal dithioketal protection followed by cyclization gives target structure single diastereoisomer form and with...