A5072176659- Phytochemical compounds biological activities
- Natural product bioactivities and synthesis
- Insect Pest Control Strategies
- NF-κB Signaling Pathways
- Multicomponent Synthesis of Heterocycles
- Phytochemistry and Bioactive Compounds
Osaka University
2022-2025
Padjadjaran University
2021-2024
The aim of this study is to overcome the challenges poor tumor penetration and systemic toxicity in targeted alpha therapy (TAT) while also evaluating its immunomodulatory effects enhance antitumor immune responses melanoma treatment. This developed a 211At-labeled single-domain antibody agent ([211At]At-AuNP-ABDMPL16) targeting PD-L1, protein overexpressed cells. binding affinity internalization [211At]At-AuNP-ABDMPL16 were evaluated vitro using cell lines. In vivo studies melanoma-bearing...
Two new azadirone-type limonoids, namely lasiocarpine A (1) and B (2) were isolated from the fruit of Chisocheton lasiocarpus along with three known limonoids (3-5). UV, IR, one- two- dimensional NMR, mass spectrometry used to determine chemical structure compounds. Furthermore, their cytotoxic activity against breast cancer cell line MCF-7 was evaluated using PrestoBlue reagent. From these compounds, showed strongest an IC50 value 43.38 μM.
Abstract In recent decades, the interest in natural products with immunomodulatory properties has increased due to their therapeutic potential. These have a wider range of pharmacological activities and demonstrate lower toxicity levels when compared synthetic counterparts. Therefore, this study aimed investigate effects sesquiterpenoids (SQs) sesquiterpenoid dimers (SQDs) isolated from Dysoxylum parasiticum (Osbeck) Kosterm. stem bark on human murine cells, particularly focusing toll-like...
Limonoid is derivatives of triterpenoid compound that have a wide variety structures due to various ring-opening, rearrangements, and high-degree oxidation. known as compounds wide-range biological activities, including anticancer activity. This research was aimed determine the chemical structure cytotoxic activity limonoid in n-hexane extract Chisocheton lasiocarpus fruit. Dried powder C. fruit extracted using methanol followed by fractionated n-hexane, ethyl acetate, n-butanol. Five...
ABSTRACT. Sesquiterpenoids are a class of terpenoid compounds with remarkable diversity structures and biological activities. primarily found in higher plants, such as the Meliaceae family's Aglaia genus. cucullata is species that still rarely explored can potentially contain sesquiterpenoid cytotoxic activity. Hence, research intended to isolate sesquiterpenoids from n-hexane extract A. stem bark evaluate their effect against A549 lung cancer cells. Compounds 1 2 were isolated purified...
Chisocarpene A (1) is a new tirucallane-type triterpenoid together with odoratone (2) and 24-methylenecycloartanol (3), isolated from the stem bark of Chisocheton lasiocarpus. The chemical structures compounds 1-3 were elucidated through detailed analysis their spectroscopic data (IR, MS, 1 D, 2 D NMR). evaluated for cytotoxic activity against MCF-7 breast cancer cell line using resazurin-based assay. Compound showed most potent (IC50 26.56 ± 1.01 µM) was two-fold more active than positive control.
Sesquiterpenoids are derivatives of terpenoid compound that have a diverse skeleton and broad spectrum biological activities, particularly anticancer activity. This research reported the isolation elucidation structure sesquiterpenoid from Chisocheton lasiocarpus stem bark, as well their cytotoxic Four compounds, namely eudesm-4(15)-ene-1β,6β-diol (1), allo-aromadendrane-10α,14-diol (2), allo-aromadendrane-10β,14-diol (3) guaianediol (4), were isolated for first time bark. The chemical all...
Senyawa katekin (flavonoid) dengan rumus molekul C15H14O6 telah diisolasi dari kulit batang chisocheton balancae C.DC (Meliacea). Penelitian ini bertujuan untuk mendapatkan senyawa (flavonoid). Sampel dimaserasi metanol dan dipartisi pelarut etil asetat. Hasil partisi asetat dipisahkan teknik kromatografi dihasilkan isolat murni berupa kristal berwarna putih (5,5 mg) titik leleh 175-1770C serapan maksimum pada panjang gelombang 280,30 nm. Struktur kimia diidentifikasi data-data spektroskopi...
The Aglaia species, which contains triterpenoids, is the most numerous in Meliaceae family. A. cucullata of there are only a few known examples, has received scant research attention. This investigation aims to identify triterpenoids an n-hexane preparation stem bark and evaluate their effects against A549 lung cancer cell line. Five dammarane-type were isolated from trunk bark, (1) (20S)-20-hydroxydammar-24-en-3-one, (2) cabraleone, (3) cabralealactone, (4) eichlerianic acid, (5)...