A5053949270- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Radioactive element chemistry and processing
- Radiopharmaceutical Chemistry and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Medical Imaging Techniques and Applications
- Covalent Organic Framework Applications
- Chemical Synthesis and Characterization
- Peptidase Inhibition and Analysis
- Geochemistry and Elemental Analysis
- Nanoplatforms for cancer theranostics
- Lanthanide and Transition Metal Complexes
- Extraction and Separation Processes
- Nanoparticle-Based Drug Delivery
- Crystallography and molecular interactions
- Nuclear Materials and Properties
- Boron Compounds in Chemistry
- Analytical chemistry methods development
- Metal Extraction and Bioleaching
- Advanced Photocatalysis Techniques
- Medical Imaging and Pathology Studies
- Adsorption and biosorption for pollutant removal
- Mine drainage and remediation techniques
- Radioactivity and Radon Measurements
- Supramolecular Chemistry and Complexes
Sichuan University
2016-2025
Sichuan University of Science and Engineering
2024
Soochow University
2023-2024
Zhoushan Hospital
2022-2023
Zhejiang Chinese Medical University
2022-2023
Chinese Academy of Sciences
2019-2022
Institute of High Energy Physics
2019-2022
University of Chinese Academy of Sciences
2019-2021
Institute of Modern Physics
2021
Ji Hua Laboratory
2021
As an excellent target for cancer theranostics, fibroblast activation protein (FAP) has become attractive focus in research. A class of FAP inhibitors (FAPIs) with a N-(4-quinolinoyl)-Gly-(2-cyanopyrrolidine) scaffold were developed, which displayed nanomolar affinity and high selectivity. Compared 90Y, 177Lu, 225Ac, 188Re, 211At seems to be more favored as therapeutic candidate FAPI tracers have fast washout short retention tumor sites. Thus, the current study reported synthesis two...
Abstract Solar‐driven photocatalytic nitrogen fixation is a low‐energy and environmentally friendly strategy for NH 3 synthesis, which considered as possible alternative to the Haber‐Bosch (HB) process. Considering extremely high bond energy of N 2 , choice photocatalysts essential reduction reaction (NRR). As class porous materials with crystallinity adjustable organic ligands, metal‐organic frameworks (MOFs) have been proven exhibit activity lot reactions. Recently, MOFs MOF‐based...
Astatine-211 is an α-emitter with high-energy α-ray and high cytotoxicity for cancer cells. However, the targeted alpha therapy (TAT) also suffers from insufficient systematic immune activation, resulting in tumor metastasis relapse. Combined checkpoint blockade (ICB) chemodynamic (CDT) could boost antitumor immunity, which may magnify responses of TAT. This study aims to discourage relapse by tri-model TAT-CDT-ICB strategy.We successfully designed Mn-based radioimmunotherapy promoters...
The systemic drug has historically been preferred for the treatment of majority pathological conditions, particularly liver cancer. Indeed, this mode is associated with adverse reactions, toxicity, off-target accumulation, and rapid hepatic renal clearance. Numerous efforts have made to design therapeutic carriers improve retention while decreasing side effects Following medication, local administration agents allows higher 'effective' doses fewer effects, kidney Hydrogels are highly...
225Ac is considered as one of the most promising radioisotopes for alpha-therapy because its emitted high-energy α-particles can efficiently damage tumor cells. However, it also represents a significant threat to healthy tissues owing extremely high radiotoxicity if targeted therapy fails. This calls pressing requirement monitoring biodistribution in vivo during treatment tumors. lack imageable photons or positrons from therapeutic doses makes this task currently quite challenging. We report...
Nano-metal–organic frameworks (nano-MOFs) labeled with radionuclides have shown great potential in the anticancer field. In this work, we proposed to combine fluorescence imaging (FI) nuclear systematically evaluate tumor inhibition of new nanomedicines from living cancer cells whole body, guiding design and application a high-performance radiopharmaceutical glioma. An Fe-based nano-MOF vector, MIL-101(Fe)/PEG-FA, was decorated fluorescent sulfo-cyanine7 (Cy7) investigate binding affinity...
99TcO4– with radioactive toxicity and high mobility is a potential radiation threat to the environment organisms. Effective separation fixation of from nuclear waste are paramount importance. Herein, we proposed pre-evaluation strategy supported by single-crystal structures prepare two kinds cationic covalent organic polymers (COPs) self-adaptive effects remove 99TcO4–/ReO4– aqueous solution. The as-prepared COPs showed rapid adsorption kinetics, large capacity, good selectivity ReO4–. Their...
How to boost the therapeutic efficiency is still key translation of anticancer nanomedicine from preclinical investigations clinical practice. In this work, we proposed integrate 211At-derived targeted-alpha therapy (TAT) and photothermal (PTT) into nanoscale polydopamine (PDA), attempting obtain a feasible solution circumvent barriers both in 211At-based endoradiotherapy common nanomedicine. After radiolabeling with 211At fibroblast activation protein inhibitor (FAPI) decoration PDA...
A thorium-based MOF formed<italic>via</italic>the synergistic construction of porphyrin and bipyridyl based on the mixed-ligand strategy has effect enhancing photocatalysis.
As well-known functional groups with excellent electro/photochromic and ion-exchange properties, bipyridinium motifs have been used in functionalized metal-organic coordination polymers, but they are still rarely applied to construct actinide polymers. In this work, we utilized a bipyridinium-based carboxylic acid, 1,1'-bis(4-carboxyphenyl)-4,4'-bipyridinium bis(chloride) ([H2bcbp]Cl2), as the organic ligand assemble uranyl cations. By introduction of different kinds auxiliary ligands...
No-carrier-added (NCA) 177Lu is one of the most interesting nuclides for endoradiotherapy. With dramatically rapid development radiopharmaceutical and nuclear medicine, there a sharp increase in radionuclide supply NCA 177Lu, which has formed great challenge to current radiochemical separation constituted on classical materials. Hence, it vital importance design prepare new functional materials able recovering from an irradiated target with excellent efficacy. In this work, we proposed apply...
This study developed an energy management system (EMS) via internet-of-things (IOT) for lighting control on a university campus in Taiwan. The structure of EMS was composed five layers: network layer using WebAccess, application software and controllers, remote I/O, equipment the equipment, perception light sensors. proposed completed successfully running smoothly online. provides valuable reference engineering technology education employed training development programs.
Abstract Promoting light absorption range of photocatalysts is great significance to improve solar light‐driven photocatalytic CO 2 reduction efficiency. Herein, a new viologen‐based multicomponent heterotrimetallic metal–organic framework (MOF) [Cu 3 Th 6 ( µ ‐O) 4 ‐OH) (cpb) 12 ][Fe III (CN) ] (IHEP‐14) with an unprecedented (6, 18)‐connected she ‐ d topology presented. Upon UV irradiation, this MOF undergoes ligand and iron photoreduction, single‐crystal‐to‐single‐crystal transformation...
Targeted radionuclide therapy based on α-emitters plays an increasingly important role in cancer treatment. In this study, we proposed to apply a heterodimeric peptide (iRGD-C6-lys-C6-DA7R) targeting both VEGFR and integrins as new vector for 211At radiolabeling obtain high-performance radiopharmaceuticals with potential targeted alpha (TAT). An astatinated peptide, iRGD-C6-lys(211At-ATE)-C6-DA7R, was prepared radiochemical yield of ∼45% high purity >95% via electrophilic...
The combination of chemotherapy and phototherapy has received tremendous attention in multimodal cancer therapy. However, satisfactory therapeutic outcomes chemo-photothermal therapy (chemo-PTT) still remain challenging. Herein, a biocompatible smart nanoplatform based on benzothiazole-linked conjugated polymer nanoparticles (CPNs) is rationally designed, for effectively loading doxorubicin (DOX) Mo-based polyoxometalate (POM) through both dynamic chemical bond intermolecular interactions,...