A5059069254- Rheumatoid Arthritis Research and Therapies
- Retinal Development and Disorders
- Musculoskeletal pain and rehabilitation
- Medical Malpractice and Liability Issues
- Photoreceptor and optogenetics research
- Otitis Media and Relapsing Polychondritis
- Musculoskeletal Disorders and Rehabilitation
- Clinical practice guidelines implementation
- Spondyloarthritis Studies and Treatments
- Spine and Intervertebral Disc Pathology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Psoriasis: Treatment and Pathogenesis
- Vasculitis and related conditions
- Chronic Lymphocytic Leukemia Research
- Systemic Lupus Erythematosus Research
- Advanced Neural Network Applications
- Health Systems, Economic Evaluations, Quality of Life
- Innovations in Medical Education
- Vitamin D Research Studies
- Cellular transport and secretion
- Healthcare Systems and Technology
- Mitochondrial Function and Pathology
- Pregnancy and Medication Impact
- Brain Tumor Detection and Classification
Imperial College London
2024
Indian Institute of Technology Kharagpur
2022-2024
University Hospitals of Leicester NHS Trust
2005-2023
National Institutes of Health
2021-2023
Ramakrishna Mission Vivekananda Educational and Research Institute
2023
R. G. Kar Medical College and Hospital
2023
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2023
Johannes Gutenberg University Mainz
2015-2022
National Eye Institute
2021
Maulana Abul Kalam Azad University of Technology, West Bengal
2021
Scope and purpose GCA is the commonest of all vasculitides. Visual loss occurs in up to one-fifth patients, which may be preventable by prompt recognition treatment [1,2]. The aim these guidelines encourage diagnosis management GCA, with emphasis on prevention visual loss. Their scope provide evidence-based advice for assessment initial further monitoring disease activity, complications relapse. This a summary full guideline available at Rheumatology online.
Scope and purpose PMR is the most common inflammatory rheumatic disease in elderly one of biggest indications for long-term steroid therapy.There are difficulties diagnosis, with heterogeneity presentation, response to steroids course.The aim these guidelines a safe specific diagnostic process PMR, using continued assessment, discouragement hasty initial treatment.Their scope provide advice diagnosis management monitoring activity, complications relapse.The GCA not covered published separately.
Mutations in the photoreceptor transcription factor gene cone-rod homeobox (CRX) lead to distinct retinopathy phenotypes, including early-onset vision impairment dominant Leber congenital amaurosis (LCA). Using induced pluripotent stem cells (iPSCs) from a patient with CRX-I138fs48 mutation, we established an vitro model of CRX-LCA retinal organoids that showed defective maturation by histology and profiling, diminished expression visual opsins. Adeno-associated virus (AAV)-mediated CRX...
The influence of sex hormone related events and smoking on the development OA in women was investigated a case-controlled postal survey. One hundred twenty-nine patients with nodal generalized osteoarthritis (NGOA) 145 non-nodal pauciarticular large joint (LJOA) were identified from database Nottingham clinic. For each patient, three age-matched controls randomly selected same general practice. Sixty-three per cent questionnaires (690/1096) returned: NGOA, 95; NGOA controls, 226; LJOA, 113;...
The Usher syndrome (USH) is the most common form of inherited deaf-blindness, accompanied by vestibular dysfunction. Due to heterogeneous manifestation clinical symptoms, three USH types (USH1-3) and additional atypical forms are distinguished. USH1 USH2 proteins have been shown function together in multiprotein networks photoreceptor cells hair cells. Mutations considered disrupt distinct protein finally lead development USH.To get novel insights into molecular pathomechanisms underlying...
THE ROLE OF CLINICAL GUIDELINES IN MEDICAL NEGLIGENCE LITIGATION: A SHIFT FROM BOLAM STANDARD? Ash Samanta, Samanta Search for other works by this author on: Oxford Academic PubMed Google Scholar Michelle M. Mello, Mello Charles Foster, Foster John Tingle, Tingle Jo *Ash Consultant Rheumatologist, University Hospitals of Leicester NHS Trust and Lecturer in Law, De Montfort University, ash.samanta@uhl-tr.nhs.co.uk. Associate Professor Health Policy Department Management, Harvard School Public...
The identification of genetic defects that underlie inherited retinal diseases (IRDs) paves the way for development therapeutic strategies. Nonsense mutations caused approximately 12% all IRD cases, resulting in a premature termination codon (PTC). Therefore, an approach targets nonsense could be promising pharmacogenetic strategy treatment IRDs. Small molecules (translational read-through inducing drugs; TRIDs) have potential to mediate by expression full-length protein. We provide novel...
Abstract Objectives To evaluate differences in bone mineral density (BMD), calcium, and vitamin D status between the Gujarati (South Asian) white populations resident Leicester to determine whether this was linked lifestyle factors. Design An observational cross sectional study of randomly selected volunteers aged from 20–40 years. Setting City Leicester. Participants Subjects were by age (20–40 years) ethnicity. A total 262 individuals volunteered participate, which 201 (51 females, 71 37...
Clinical guidelines are statements that have been systematically developed and which aim to assist clinicians in making decisions about treatment for specific conditions1. They linked evidence meant facilitate good medical practice. The National Institute Excellence (NICE) is part of the Government's agenda healthcare. One its main functions develop, issue encourage use objective guidelines, thus promoting ‘best practice’. A key follows how lawyers courts might such litigation. At heart...
Summary A 19 year old male veterinary nurse accidentally injected himself with 200 mg of xylazine (a muscle relaxant and sedative used in practice). He subsequently became comatose, hypotensive, bradycardic acidotic. required intensive supportive therapy, made a full recovery over the next few hours. Xylazine toxicity humans is very rare, effects are discussed.
Ataluren and Gentamicin are translational readthrough drugs (TRIDs) that induce premature termination codon (PTC) readthrough, resulting in the production of full-length proteins usually harbor a single missense substitution. FAM161A is ciliary protein which expressed photoreceptors, pathogenic variants this gene cause retinitis pigmentosa (RP). Applying TRIDs on fibroblasts from RP patients due to PTC (p.Arg523*) may uncover whether can restore expression, localization function protein....
To determine whether consultant rheumatologists monitor the ocular toxicity of hydroxychloroquine according to standards set by national guidelines.An observational cross-sectional questionnaire study all in UK was undertaken. The main outcome measure proportion who practise compliance with nationally standards.A wide variation practice found. Nearly half respondents did not assess either baseline visual symptoms or acuity, and 3% undertook infrequent monitoring at intervals longer than 1...
Introduction . WHO recognizes low back pain as one of the most important ergonomic stressors. Therefore, present study was designed to find out magnitude problem among jute mill workers in India and identify possible associations. Methodology This cross-sectional workplace based conducted eight (8) selected mills India. Subjects with self-reported for at least last 12 weeks were included <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
To assess the acceptability for use of information on osteomalacia South Asian patients.Ten focus groups persons speaking Bengali, Gujarati, Hindi, Punjabi and Urdu (one male one female group each language) were used to evaluate written (leaflets) spoken (CD) patients produced by Arthritis Research Campaign (ARC). Focus discussion was facilitated community-based workers using Social Action Method. A subsidiary evaluation conducted a questionnaire-based survey sent British Society...
The past decade witnessed a series of high-profile inquiries that cast noxious miasma over the medical profession and provoked demands for strict regulation. Somehow, balance must be struck whereby public can confident doctors practise competently, with due regard to ethical technical standards, yet regulations are not so overwhelming as represent sword Damocles permanently hanging doctors' heads. This article explores current regulatory framework, exclusion from workplace, serious...
In response to a stimulus, distinct areas of the human brain are activated. Also, it is known that regions interact with one another. This functional connectivity helpful diagnose any neurological abnormality, such as autism spectrum disorder (ASD). work proposes an approach construct network from fMRI image data. For obtaining network, time series component data used and correlation matrix calculated showing degree interaction among regions. To map different brain, atlas considered....
Of the 418 consecutive patients attending a general medical clinic for follow-up, 113 (27%) had appointments in another same or related problem; 98 of them (87%) were different hospital. The reasons multiple attendance routine follow-up after hospital admission 55 (49%), referrals from practitioners to more than one 33 (30%), and cross-referrals 'parent' firm 19 (17%). In six no clear reason attendances could be identified. More half (55%) over 65 years old, 45% lived five miles hospital,...