A5045960408- Saffron Plant Research Studies
- Neurological Disease Mechanisms and Treatments
- Computational Drug Discovery Methods
- Ginger and Zingiberaceae research
- Phytochemistry and Biological Activities
- Plant chemical constituents analysis
- Immune Response and Inflammation
- Flavonoids in Medical Research
- Peptidase Inhibition and Analysis
- Chromatography in Natural Products
- Ideological and Political Education
- Wnt/β-catenin signaling in development and cancer
- Cancer Treatment and Pharmacology
- Healthcare and Venom Research
- Click Chemistry and Applications
- Chemokine receptors and signaling
- Phytochemistry and Bioactive Compounds
- Kruppel-like factors research
- Herbal Medicine Research Studies
- Nanoplatforms for cancer theranostics
- Genomics, phytochemicals, and oxidative stress
- Renal Diseases and Glomerulopathies
- Pharmacological Effects of Natural Compounds
- Immune Cell Function and Interaction
- Synthesis and biological activity
Third Affiliated Hospital of Southern Medical University
2019-2025
Chongqing University of Education
2011-2023
University of Education, Winneba
2013
Nanjing University of Posts and Telecommunications
2013
The therapeutic effect on HCl/ethanol induced gastric injury of Gardenia jasminoides (JXGJ-1 and JXGJ-2) were determined by a animal model. JXGJ-2 group reduced area its as compared to the control group, also helped in decreasing secretion volume results raised pH value. NO contents serum, heart, liver, kidney stomach more than JXGJ-1 groups. reduce cytokine levels group. serum tissue SOD, GSH-Px, GSH treated mice higher mice, but MDA, PC showed crosscurrents, these close normal mice. could...
Radioresistance presents a major challenge in the treatment of cervical cancer (CC). Apoptotic tumor cells can create an "onco-regenerative niche," contributing to radioresistance. However, intercellular signaling mechanisms mediating transfer radioresistance from apoptotic surviving remain unclear. The role cell-derived extracellular vesicles (apoEVs) was investigated through integrated bioinformatics and experimental approaches. GSE236738 dataset analyzed identify potential regulators,...
Gardenia jasminoides is a plant that has been used in traditional Chinese medicine. It four key active components (genipin gentiobioside, geniposide, crocin 1 and 2). The aim of the present study was to determine anti‑hypertension effects jasminoidesin vivo. chemical composition determined using liquid chromatography. anti‑hypertensive were by L‑NG‑nitroarginine (L‑NNA)‑induced hypertension animal model. Both plants Jiangjin County variety (CJGJ) Lichuan City (HLGJ) used. HLGJ contained more...
In the present study preventive effect of polysaccharides from large yellow croaker swim bladder (PLYCSB) on HCl/ethanol-induced gastric injury in ICR mice was investigated. A high dose PLYCSB (50 mg/kg) found to reduce levels serum proinflammatory cytokines interleukin (IL)-1β, IL-6, IL-8, as well increase IL-4 compared with those treated a low (25 and control mice. The somatostatin vasoactive intestinal peptide PLYCSB-treated were higher mice, whilst motilin substance P lower extent that...
The antitumor activity of Juemingzi (Cassia tora L.) was investigated in mice that were fed various concentrations the compound. Although a low concentration (50 mg/kg b.w.) exhibited high tumor weight, higher feeding (100 and 200 associated with lower weight tumors. growth rate mouse splenocytes treated b.w. determined using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide assay. This proliferation than achieved 100 50 treatment by fetal bovine serum, lipopolysaccharide or...
To design a releasable PEGylated TNF-α (rPEG-TNF-α), cathepsin B-sensitive dipeptide (Val-Cit moiety) was inserted into conventional PEG-modified (PEG-TNF-α), facilitating its clinical use for anti-tumor therapy. Comparative pharmacokinetic and pharmacodynamic studies showed that the half-lives of both forms were ∼60-fold greater than unmodified TNF-α. In addition, in vitro bioactivity rPEG-TNF-α PEG-TNF-α with same degree PEG modification. Release from dependent on presence B inhibited by...
Abstract Human angiotensin‐I‐converting enzyme (ACE) is an important target of antihypertensive therapy, which possesses a bulky, hydrophobic pocket that physicochemically compatible with wide variety peptide substrates and small‐molecule ligands. Rational design potent ACE inhibitors has long been attractive topic in the chemical, biological medical communities. In present study, integrative protocol described to optimize modify peptides bound based on their complex three‐dimensional...
Visualization of molecular interaction profile involved in chemical and biological systems could provide a straightforward way for understanding various disease processes the development appropriate medical therapies. However, traditional imaging techniques tend to showing architecture at three-dimensional (3D) level; this blurry information complex network distorted interfacial profile, some cases, are unable be sufficiently presented audiences. Alternatively, diagrams generated using...
The anticancer activity of Peucedanum praeruptorum Dunn extract (PPDE) was investigated in vitro the HepG2 human hepatoma cell line and compared to normal liver cells (L02 cells). effect PPDE on proliferation measured by MTT assays, levels enzymes small molecules implicated oxidative stress regulation were using specific reagent kits. expression genes apoptosis (Bax, Bcl-2, caspase-3, caspase-8, caspase-9) (SOD1 SOD2) quantified RT-qPCR. Lastly, HPLC employed analyze composition PPDE. found...
Peucedanum praeruptorum Dunn extract (PPDE) is a well-known treatment used in traditional Chinese medicines, where it most commonly to treat coughs and symptoms such as headaches fever. In the present study, antioxidant capacity of PPDE vitro was determined by scavenging experiments using DPPH, ABTS+·, ·OH, ·O2-. The cell survival rate MTT assay. MDA, SOD, CAT, GSH, GSH-Px content were colorimetry assays. expression levels genes assessed reverse transcription-quantitative PCR. HPLC identify...
Peucedanum praeruptorum Dunn is a natural plant with expectorant, antitussive, anti-asthmatic, anti-inflammatory, antispasmodic and sedative effects. It used in traditional Chinese medicine. The key active substances extracted after separation are also to process functional food. Recent advances the development of industrially have increased market demand. In particular, study physiological activity P. has always been research hotspot; however, limited data exist currently. This reviews...
Gardenia jasminoides Ellis, a dried and mature fruit of the Rubiaceae family plant, is traditional Chinese medicine with rich medicinal nutritional value that designated by city state as dual use medicine. In recent years, studies have found has an anti-tumor effect. Some active ingredients in can inhibit growth proliferation cancer cells, also induce apoptosis so to play role, especially anti colon cancer, liver breast lung cancer. By summarizing analyzing research on anticancer effect...