A5100655640- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- HER2/EGFR in Cancer Research
- Cancer Immunotherapy and Biomarkers
- Liver physiology and pathology
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Neuroendocrine Tumor Research Advances
- Gastrointestinal Tumor Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Pharmacological Effects of Natural Compounds
- Soft tissue tumor case studies
- Biological and pharmacological studies of plants
- RNA modifications and cancer
- Saffron Plant Research Studies
- Renal cell carcinoma treatment
- Liver Disease Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
Nantong University
2014-2025
Bengbu Medical College
2006-2024
Nanjing University of Chinese Medicine
2020-2024
Jiangsu Province Hospital
2020-2024
Wenzhou Medical University
2024
Yancheng First People's Hospital
2014-2023
Xuzhou Medical College
2023
The First Affiliated Hospital, Sun Yat-sen University
2021-2022
Zhongshan Hospital
2021-2022
Sun Yat-sen University
2021-2022
Abstract Purpose: Glioblastoma is the most aggressive primary brain tumor in adults with a median survival of 15–20 months. Numerous approaches and novel therapeutics for treating glioblastoma have been investigated setting phase III clinical trials, including recent analysis immune checkpoint inhibitor, nivolumab (anti-PD-1), which failed to improve recurrent patient survival. However, rather than abandoning inhibitor treatment glioblastoma, has shown promise other types cancer, ongoing...
Rationale: Patients with indeterminate pulmonary nodules (IPNs) at risk of cancer undergo high rates invasive, costly, and morbid procedures. Objectives: To train externally validate a prediction model that combined clinical, blood, imaging biomarkers to improve the noninvasive management IPNs. Methods: In this prospectively collected, retrospective blinded evaluation study, probability was calculated for 456 patient using Mayo Clinic model, patients were categorized into low-,...
Somatostatin receptor 2 (SSTR2) is overexpressed in a majority of neuroendocrine neoplasms, including small-cell lung carcinomas (SCLCs). SSTR2 was previously considered an inhibitory on cell growth, but its agonists had poor clinical responses multiple trials. The role this as potential therapeutic target cancer merits further investigation. We evaluated the expression cohort 96 primary tumors from patients with SCLC and found 48% expressed SSTR2. Correlation analysis both CCLE RNAseq...
The therapeutic effect on HCl/ethanol induced gastric injury of Gardenia jasminoides (JXGJ-1 and JXGJ-2) were determined by a animal model. JXGJ-2 group reduced area its as compared to the control group, also helped in decreasing secretion volume results raised pH value. NO contents serum, heart, liver, kidney stomach more than JXGJ-1 groups. reduce cytokine levels group. serum tissue SOD, GSH-Px, GSH treated mice higher mice, but MDA, PC showed crosscurrents, these close normal mice. could...
The prevalence, incidence and risk factors of atrial fibrillation (AF) in a large, geographically ethnically diverse cohort the United States have not been fully described.
Epidermal growth factor receptor (EGFR) activation was reported to upregulate programmed death-ligand 1 (PD-L1) expression in lung cancer cells and subsequently contribute immune escape, indicating its critical role EGFR-driven tumors. This study characterized PD-L1 patients with surgically resected EGFR-mutant non-small cell (NSCLC). The effect of on clinical outcomes also investigated advanced NSCLC treated EGFR-tyrosine kinase inhibitors (TKIs).In total, 73 EGFR mutations were identified....
To evaluate the predictive value of decline in serum level carbohydrate antigen 724 (CA724) on tumor response during chemotherapy patients with advanced gastric carcinoma (GC).The CA724 was determined by electrochemiluminescence immunoassay, while objective rate (ORR) assessed according to evaluation criteria solid tumors (RECIST). The association changes concentration ORR analyzed.The (pretreatment level) high and low groups 32.3% (20/62) 52.8% (19/36), respectively (P=0.045). relationship...
Human epidermal growth factor receptor 2 (H ER2) is a member of the ErbB family and key proto-oncogene in solid tumors. This pilot study investigated safety efficacy pyrotinib HER2-positive non-breast advanced Twenty-five patients with tumors excluding breast cancer were enrolled to receive pyrotinib-based therapy. The primary end point was progression-free survival (PFS). median PFS overall (OS) 3.5 months (95% CI: 2.2-5.0 months) 9.6 4.4-9.9 months), respectively. Ten lung 9 gastric had...
Abstract Preoperative prediction of tumor recurrence after radiofrequency ablation (RFA) in patients with early hepatocellular carcinoma (HCC) is helpful for clinical decision-making before treatment. A total 162 HCC 3 cm or less who were completely ablated by percutaneous RFA divided into a derivation cohort (n = 108) and validation 54). Based on X-Tiles software, Kaplan–Meier curve analysis COX multivariate to obtain valuable predictive indicators, scoring system predicting was...
Objective To compare the effects of transcatheter arterial chemoembolization (TACE) with embolization (TAE) on liver function, hepatic damage, and fibrogenesis in a rabbit tumor model. Materials Methods Thirty-nine New Zealand white rabbits implanted VX2 tumors left lobes were randomly divided into three groups: TAE, TACE, control group. In TAE group (n = 15), polyvinyl alcohol particles (PVAs) used for artery embolization. TACE treated infusions suspension 10-hydroxycamptothecin lipiodol,...
To evaluate and compare the effect of combined transarterial chemoembolization (TACE) arterial administration Bletilla striata (a Chinese traditional medicine against liver tumor) versus TACE alone for treatment hepatocellular carcinoma (HCC) in ACI rats.Subcapsular implantation a solid Morris hepatoma 3 924A (2 mm3) was carried out 30 male rats. Tumor volume (V1) measured by magnetic resonance imaging (MRI) on day 13 after implantation. The following different agents interventional were...
BACKGROUND The aim of this study was to detect the expression levels chemokines (CX3CL1, CXCL-11, CXCL-12, CCL3, CCL4, and CCL20) in serum esophageal cancer patients a normal control group, explore correlations those with pathological type, progression, metastasis cancer. MATERIAL AND METHODS A total 50 people untreated initially diagnosed (including 17 cases non-metastatic cancer, 33 metastatic 36 squamous cell carcinoma 14 adenocarcinoma) were collected. liquid chip (Luminex) technology...
The predictors for the prognosis of gastric cancer (GC) are not clear.We intended to explore role PTEN and microsatellite (MS) in GC, showing their potential as prognostic markers.Primary tissues, adjacent normal clinicopathological parameters 187 patients were collected.The expression level MS status classified by immunohistochemistry (IHC).The relationship among indicators was compared chi-square test.The survival curves delineated Kaplan-Meier tested Log-rank methods.The impact multiple...
Mechanical compression is important in disc degeneration. N-cadherin (N-CDH)-mediated signaling contributes to the maintenance of normal nucleus pulposus (NP) cell phenotype and NP matrix biosynthesis. Our preliminary study demonstrated that a high‑magnitude (20% deformation) promotes senescence three‑dimensional scaffold culture system. The aim present was investigate whether N‑CDH‑mediated alleviates under above‑mentioned compression. cells were transfected with recombinant lentiviral...
Background: Gastric cancer (GC) is one of the leading causes cancer-related death worldwide. This study was designed to investigate prognostic values red blood cell (RBC)-associated indicators, including RBC, hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), (MCH), concentration (MCHC), and RBC distribution width (RDW) in resectable GC patients. Methods: In this retrospective study, a total 104 pathologically confirmed patients were recruited. These cases divided into two...